Lower Back Pain Clinical Trials
Lower Back Pain studies recruiting patients for novel treatments. Filter by phase, distance, and inclusion criteria to find your perfect lower back pain clinical trial.
Condition
Lower Back Pain
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Distance
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Clinical Trials
Lower Back Pain Clinical Trials
Phase-Based Estimates
1
Effectiveness
1
Safety
Self-administered Acupressure
for Back Pain
Ann Arbor, MI
18+
All Sexes
Waitlist Available
Ann Arbor, MI
18+
All Sexes
Many Veterans experience chronic pain, with back pain the most commonly reported condition. The Veterans Health Administration (VHA) is moving from reliance on medications to an approach in which non-medication interventions, including complementary and integrative health treatments, are now a first line of care. Acupressure, a Traditional Chinese Medicine technique derived from acupuncture, is emerging as a potentially effective approach for treating several chronic pain conditions and could prove beneficial in helping Veterans manage their chronic low back pain. This study will determine the effectiveness of self-administered acupressure to treat chronic low back pain. 300 Veterans will be invited to participate in the study. All participants will be asked to attend an introduction to acupressure class and complete a survey when they join the study and again at 6 weeks and 10 weeks. The survey measures assess important outcomes, such as how pain interferes with daily function, as well as other areas that can be affected by pain such as fatigue and sleep quality. After completing the first survey, half of the participants will receive a tablet computer with an app that shows them how to self-administer acupressure for low back pain and will be asked to do daily acupressure sessions for the next 6 weeks. The other half of the participants will receive the tablet computer with the app approximately 10 weeks after completing the final survey based assessment. The investigators anticipate that outcomes will be improved after 6 weeks of acupressure practice, and these improvements will persist for the following 4 weeks.
Phase-Based Estimates
1
Effectiveness
1
Safety
Group-supervised Physiotherapy Training Programs
for Rotator Cuff Tendinitis
Québec, Canada
18 - 65
All Sexes
Recruiting
Québec, Canada
18 - 65
All Sexes
This randomized controlled trial will compare the mid- and long-term effects of group-based training programs with usual individual physiotherapy care for the treatment of musculoskeletal disorders in military. One hundred and twenty soldiers presenting one of the four targeted musculoskeletal disorders (low back pain, rotator cuff related pain, patellofemoral pain syndrome or lateral ankle sprain) will be recruited and randomly assigned to either a 12-weeks group-based training program or 12-weeks usual individual physiotherapy care.
Phase-Based Estimates
3
Effectiveness
3
Safety
VIA Disc NP
for Intervertebral Disc Degeneration
Cleveland, OH
18+
All Sexes
Phase 4
Recruiting
Grade III
Cleveland, OH
18+
All Sexes
VIA Disc NP is a non-surgical intervention intended to replace nucleus pulposus tissue in degenerated intervertebral discs.
Phase-Based Estimates
1
Effectiveness
1
Safety
Dry Needling
for Low Back Pain
Dallas, TX
18+
All Sexes
Waitlist Available
Dallas, TX
18+
All Sexes
This study is evaluating whether a single session of dry needling can change the excitability of the brain in people with chronic low back pain.
Phase-Based Estimates
1
Effectiveness
1
Safety
Supported Biopsychosocial Self-Management (SBSM)
for Low Back Pain
Minneapolis, MN
18+
All Sexes
Recruiting
Minneapolis, MN
18+
All Sexes
This study is evaluating whether a self-management intervention is more effective than medical care for chronic low back pain.
Phase-Based Estimates
2
Effectiveness
3
Safety
Brief Pain Teleconsult
for Low Back Pain
Salt Lake City, UT
18+
All Sexes
Phase 3
Recruiting
Salt Lake City, UT
18+
All Sexes
This study is evaluating whether a telehealth approach can improve pain management for patients with chronic back pain.
Phase-Based Estimates
1
Effectiveness
1
Safety
ED Physical Therapy
for Low Back Pain
Chicago, IL
18+
All Sexes
Recruiting
Chicago, IL
18+
All Sexes
This study is evaluating whether an emergency department physical therapy model can improve patient functioning and reduce opioid use.
Phase-Based Estimates
1
Effectiveness
1
Safety
Manual Therapy
for Low Back Pain
Montréal, Canada
18+
All Sexes
Waitlist Available
Montréal, Canada
18+
All Sexes
This study is evaluating whether a set of therapies can improve the physical properties of muscles and connective tissues in people with chronic low back pain.
Phase-Based Estimates
1
Effectiveness
1
Safety
Protein Supplement
for Low Back Pain
San Diego, CA
18+
All Sexes
Waitlist Available
San Diego, CA
18+
All Sexes
This study is evaluating whether a physical therapy program with nutritional supplements may help individuals with neck, back, or shoulder pain.
Phase-Based Estimates
3
Effectiveness
3
Safety
Topical Diclofenac
for Low Back Pain
New York, NY
18+
All Sexes
Phase 4
Recruiting
New York, NY
18+
All Sexes
This study is evaluating whether ibuprofen and diclofenac may help reduce pain for individuals with acute low back pain.
Phase-Based Estimates
1
Effectiveness
1
Safety
Intervention
for Low Back Pain
Sacramento, CA
18+
All Sexes
Waitlist Available
Sacramento, CA
18+
All Sexes
This study is evaluating whether standardized patients can help primary care physicians learn to offer watchful waiting to patients with acute low back pain.
Phase-Based Estimates
1
Effectiveness
1
Safety
GV26 With Manual Tonification
for Low Back Pain
Nellis Air Force Base, NV
18+
All Sexes
Recruiting
Nellis Air Force Base, NV
18+
All Sexes
This study is evaluating whether acupuncture may help reduce pain for individuals with acute low back pain.
Phase-Based Estimates
1
Effectiveness
2
Safety
Metformin
for Low Back Pain
Wexford, PA
18+
All Sexes
Phase 2
Recruiting
Wexford, PA
18+
All Sexes
This study is evaluating whether a drug used to treat diabetes may help treat back pain.
Phase-Based Estimates
1
Effectiveness
1
Safety
MR Neurography-guided Cryoanalgesia
for Pelvic Pain
Baltimore, MD
18+
All Sexes
Recruiting
Baltimore, MD
18+
All Sexes
This study is evaluating whether a new procedure may help reduce pain for individuals with pelvic pain.
Phase-Based Estimates
2
Effectiveness
3
Safety
Physical Therapy
for Low Back Pain
Salt Lake City, UT
18 - 65
All Sexes
Phase 3
Recruiting
Salt Lake City, UT
18 - 65
All Sexes
This study is evaluating whether a new approach to treating chronic low back pain may be more effective than current treatments.
Phase-Based Estimates
1
Effectiveness
1
Safety
Two-point Discrimination Training
for Syndrome
Cincinnati, OH
< 18
All Sexes
Phase < 1
Recruiting
Cincinnati, OH
< 18
All Sexes
SPECIFIC AIMS Pain in both youth and adults is a complex, subjective and personal experience, and remains poorly understood. One particularly perplexing dimension of some forms of pain is the tendency of pain to spread outside of an affected body site to adjacent location, and then to unaffected body sites. Such widespread pain may reflect an altered spatial tuning of somatosensory processing, such that lateral inhibition is diminished, thereby allowing pain to spread. To date, no therapies exist which are designed specifically to diminish or even reverse the spatial spread of pain. However, training in two-point discrimination holds the potential to retune spatial aspects of somatosensory processing and may represent a novel therapy for widespread pain. Thus, the present investigation will test the following aims: Aim 1. Do youth with chronic pain have disrupted spatial tuning of somatosensory processing? Deficits in two point tactile discrimination have long been noted in adults with chronic pain, but such deficits remain poorly documented in pediatric chronic pain patients. In order to determine if such deficits exist, youth with both chronic pain and healthy youth will undergo assessment of two point discrimination thresholds. Aim 2. Does two-point discrimination training result in diminished pain and disability in youth with somatic pain? After initial characterization of tactile discrimination thresholds, youth with chronic pain will participate in multiple sessions of either two-point discrimination training or a single-point spatially-directed attentional control condition. Training will involve up to 9 additional sessions. Efficacy of training will be assessed by 1) reductions in the spatial extent of pain, 2) reductions in pain intensity and unpleasantness, and 3) reductions in pain-related disability.
Phase-Based Estimates
1
Effectiveness
2
Safety
D-cycloserine
for Low Back Pain
Chicago, IL
18+
All Sexes
Phase 2
Recruiting
Chicago, IL
18+
All Sexes
This study is evaluating whether a drug may help relieve chronic lower back pain.
Phase-Based Estimates
3
Effectiveness
3
Safety
Eplerenone 50 Mg Tab
for Radiculitis
West Chester, OH
18+
All Sexes
Phase 4
Recruiting
West Chester, OH
18+
All Sexes
Low back pain is a leading cause of disability and health care costs in the United States, and treatments are ineffective for many patients. Epidural steroid injections are a common treatment, but their efficacy has been questioned and for many patients they do not provide complete relief. The investigators hypothesize, based on preclinical studies, that lack of complete efficacy may be due to the fact that clinically used steroids activate not only the intended drug target, the glucocorticoid receptor, but also the pro-inflammatory mineralocorticoid receptor. To test this hypothesis, this pilot study will recruit patients scheduled for lumbar epidural steroid injections for degenerative disc disease, and randomize them to receive a concurrent treatment with oral eplerenone (a clinically approved antagonist of the mineralocorticoid receptor) or placebo for 10 days starting just after the epidural injection. At several time points during the following year, subjects will answer the Oswestry Low Back Pain Questionnaire, to report on both pain and functional outcomes.
Phase-Based Estimates
1
Effectiveness
2
Safety
Magnetic Resonance-Positron Emission Tomography Imaging
for Back Pain
Charlestown, MA
18+
All Sexes
Phase 2
Recruiting
Charlestown, MA
18+
All Sexes
This study is evaluating whether minocycline may help reduce neuroinflammation and low back pain symptoms.
Phase-Based Estimates
1
Effectiveness
1
Safety
Pain Verbalization Repression Rules
for Back Pain
Pittsburgh, PA
18+
All Sexes
Waitlist Available
Pittsburgh, PA
18+
All Sexes
This study is evaluating whether limiting complaints can reduce pain and pain catastrophizing in people with low back pain.
Phase-Based Estimates
1
Effectiveness
1
Safety
Clinical Screening
for Back Pain
Newark, DE
18+
All Sexes
Recruiting
Newark, DE
18+
All Sexes
Lower-limb amputation is associated with life-altering and life-limiting comorbidities. Currently, onus is on primary care providers to diagnose, educate, and refer patients for appropriate management. Recently our laboratory has found, however, that of adults post-amputation seen in an outpatient Limb Loss Clinic presenting with comorbidities, >50% are unaware they have signs of peripheral arterial disease and/or neuropathy. Lack of patient awareness and thus, inadequate comorbidity management, may contribute to suboptimal patient outcomes post-amputation. As a first step in this research line, the proposed project will help determine if comorbidity screening by prosthetists during routine care visits for patients post-amputation may enhance comorbidity awareness, increase patient satisfaction in prosthetic services, and reduce gratuitous prosthetic service utilization. During a follow-up visit, seventy patients following a unilateral lower-limb amputation will be randomized into either a standard-of-care group or a standard of-care plus group. The standard-of-care plus group will receive clinical screenings by a certified prosthetist for peripheral arterial disease, peripheral neuropathy, depression, and high-risk for persistent back pain; patient education on findings; and each participant's primary care provider will receive screening results. The long-term goal of this research is to determine if prosthetists can maximize their utility in an interdisciplinary care team, while enhancing patient outcomes post-amputation.
Phase-Based Estimates
1
Effectiveness
1
Safety
Usual Care Physical Therapy
for Low Back Pain
Nashville, TN
18+
All Sexes
Recruiting
Nashville, TN
18+
All Sexes
Randomized Clinical Trail (RCT) for patients already planned to attend physical therapy for chronic low back pain. Patients will be randomized to receive Physical Therapy (PT) as usual or PT plus pain education delivered via virtual-reality headset.
Phase-Based Estimates
2
Effectiveness
3
Safety
Dextrose 50% Intravenous Solution
for Syndrome
New Orleans, LA
18+
All Sexes
Phase 3
Waitlist Available
New Orleans, LA
18+
All Sexes
Specific Aim: To show the safety and efficacy of prolotherapy injection for chronic sacroiliac and myofascial lumbar pain while standardizing an ultrasound guided injection technique Specific Aim: To demonstrate that dextrose prolotherapy subjectively decreases lumbar back pain (LBP) associated with chronic sacroiliac (SI) and myofascial lumbar back pain/injury in patients with Hypermobile-Type Ehlers-Danlos Syndrome (hEDS). Specific Aim: To use ultrasound (US) guidance to identify SI and myofascial lumbar back pain/injury for targeted dextrose prolotherapy treatment and to provide objective measures of decreasing inflammation via Power Doppler and ligament repair. Specific Aim: To determine if US-guided dextrose prolotherapy decreases the direct costs of care for chronic LBP in contrast to conventional therapies by reducing return visits, specialty referrals, physical therapy, medications, and unnecessary procedures.
Phase-Based Estimates
1
Effectiveness
1
Safety
ED Physical Therapy
for Back Pain
Chicago, IL
18+
All Sexes
Recruiting
Chicago, IL
18+
All Sexes
Emergency department (ED)-initiated physical therapy is a rapidly growing resource and represents a promising treatment approach to low back pain. This clinical trial will evaluate an innovative model of an emergency department "embedded" physical therapist to treat patients with chronic low back pain, with a focus on improving patient functioning and reducing opioid use.
Phase-Based Estimates
1
Effectiveness
2
Safety
SP-103
for Low Back Pain
Boise, ID
18+
All Sexes
Phase 2
Recruiting
Boise, ID
18+
All Sexes
This study is evaluating whether a drug called SP-103 can help people with back pain.
Phase-Based Estimates
1
Effectiveness
1
Safety
GOALS Intervention
for Chronic Pain
San Diego, CA
18+
All Sexes
Recruiting
San Diego, CA
18+
All Sexes
This study is evaluating whether a cognitive behavioral physical therapy program can help people with chronic neck or low back pain.
Phase-Based Estimates
1
Effectiveness
1
Safety
Spinal Cord Stimulation
for Neuralgia
Greenville, SC
18+
All Sexes
Recruiting
Greenville, SC
18+
All Sexes
This study is evaluating whether it is possible to automatically adjust stimulation in patients undergoing spinal cord stimulation.
Phase-Based Estimates
1
Effectiveness
1
Safety
StimaWell 120MTRS System
for Back Pain
Montreal, Canada
18 - 65
All Sexes
Recruiting
Montreal, Canada
18 - 65
All Sexes
This study is evaluating whether a 10-week long intervention with the StimaWELL 120MTRS system can improve multifidus morphology and function in individuals with chronic low back pain.
Phase-Based Estimates
1
Effectiveness
1
Safety
In-Person (or Remote) Intervention
for Low Back Pain
Gainesville, FL
18+
All Sexes
Recruiting
Gainesville, FL
18+
All Sexes
The central objective of research is to examine the feasibility and acceptability of an 8-month single-arm behavioral intervention (i.e., EMPOWER) among overweight/obese middle-aged and older adults with moderate-to-high impact low back pain. Intervention content will focus on standard behavioral weight loss treatment and cognitive-behavioral pain coping therapy with a focus on environmental reward and positive affect.
Phase-Based Estimates
1
Effectiveness
1
Safety
Sham Massage Technique
for Low Back Pain
Montréal, Canada
18+
All Sexes
Recruiting
Montréal, Canada
18+
All Sexes
In this prospective study, eligible subjects with chronic non specific low back pain and asymptomatic volunteers will undergo a research dynamic ultrasound exam of the lower back before and after a massage technique. The overall aim of the present research is to develop ultrasonographic parameters that characterize the geometrical, the mechanical and tissue characteristic properties of the thoracolumbar fascia, and to explore the effect of a massage therapy technique on these parameters.
Phase-Based Estimates
1
Effectiveness
1
Safety
Resistance Exercise
for Back Pain
Rochester, MN
18+
All Sexes
Waitlist Available
Rochester, MN
18+
All Sexes
This study is evaluating whether a device which makes sounds may help reduce pain for individuals with lower back pain.
Phase-Based Estimates
1
Effectiveness
1
Safety
Targeted Exercise Program
for Low Back Pain
Montréal, Canada
18+
All Sexes
Recruiting
Montréal, Canada
18+
All Sexes
This study is evaluating whether a targeted exercise program can improve paraspinal muscle function and disability in people with chronic low back pain.
Phase-Based Estimates
1
Effectiveness
1
Safety
Physical Therapy
for Low Back Pain
San Antonio, TX
18+
All Sexes
Recruiting
San Antonio, TX
18+
All Sexes
This study is evaluating whether a combination of physical therapy and mindfulness training may help individuals with chronic low back pain.
Phase-Based Estimates
1
Effectiveness
1
Safety
PRP Treatment
for Back Pain
Lone Tree, CO
18+
All Sexes
Waitlist Available
Grade II
Lone Tree, CO
18+
All Sexes
This study is evaluating whether injections of different substances into the back may help treat lower back pain.
Phase-Based Estimates
1
Effectiveness
1
Safety
Soft Tissue Mobilization
for Low Back Pain
Lubbock, TX
18 - 65
Female
Recruiting
1 Prior Treatment
Lubbock, TX
18 - 65
Female
This study is evaluating whether a physical therapy treatment known as soft tissue mobilization (tSTM) can improve back pain in pregnancy.
Phase-Based Estimates
1
Effectiveness
1
Safety
Positive Piggy Bank
for Back Pain
Ann Arbor, MI
18+
All Sexes
Waitlist Available
Ann Arbor, MI
18+
All Sexes
This study is evaluating whether a set of activities can improve functional status in people with chronic pain.
Phase-Based Estimates
1
Effectiveness
1
Safety
Osteopathic Manipulative Medicine
for Back Pain
Old Westbury, NY
18+
All Sexes
Recruiting
Old Westbury, NY
18+
All Sexes
This study is evaluating whether a combination of Osteopathic Manipulative Medicine (OMM) and phototherapy may help individuals with chronic lower back pain.
Phase-Based Estimates
1
Effectiveness
1
Safety
EaseVRx
for Anxiety
Van Nuys, CA
18+
All Sexes
Recruiting
Van Nuys, CA
18+
All Sexes
The aim of this randomized controlled trial (RCT) is to assess outcomes for virtual reality therapy (including pain intensity, pain interference, anxiety, depression, physical function, sleep, behavioral skills development, health outcomes and satisfaction) along with healthcare utilization and costs in participants with Chronic Low Back Pain.
Other Trials to Consider
LY3526318
for Chronic Lower Back Pain (CLBP)
Phase-Based Estimates
1
Effectiveness
2
Safety
Phase 2
Recruiting
Riverside, CA
18+
All Sexes
SP-103
for Low Back Pain
Phase-Based Estimates
1
Effectiveness
2
Safety
Phase 2
Recruiting
Boise, ID
18+
All Sexes
Self-Natural Posture Exercise Training
for Low Back Pain
Phase-Based Estimates
1
Effectiveness
1
Safety
Waitlist Available
Billings, MT
18+
All Sexes
Rage Against The Pain (RAP)
for Back Pain
Phase-Based Estimates
1
Effectiveness
1
Safety
Waitlist Available
Hines, IL
18+
All Sexes
PerQdisc® Nucleus Replacement Device.
for Low Back Pain
Phase-Based Estimates
1
Effectiveness
1
Safety
Waitlist Available
Montreal, Canada
18 - 65
All Sexes
Platelet Rich Plasma Injection To The Lumbar Facet Joint
for Low Back Pain
Phase-Based Estimates
1
Effectiveness
1
Safety
Recruiting
Fort Bragg, NC
18+
All Sexes
Psychologically-Informed Physical Therapy (PIPT)
for Back Pain
Phase-Based Estimates
1
Effectiveness
1
Safety
Waitlist Available
Durham, NC
18+
All Sexes
Behavioral Intervention Group
for Back Pain
Phase-Based Estimates
1
Effectiveness
1
Safety
Recruiting
Dallas, TX
18+
All Sexes
Behavioral Intervention Group (MOTIVATE)
for Back Pain
Phase-Based Estimates
1
Effectiveness
1
Safety
Waitlist Available
Dallas, TX
18+
All Sexes
BTL 4110 Smart Laser Therapy Equipment (BTL Industries Ltd, United Kingdom (UK))
for Low Back Pain
Phase-Based Estimates
1
Effectiveness
1
Safety
Waitlist Available
Mississauga, Canada
18+
All Sexes
EaseVRx
for Anxiety
Phase-Based Estimates
1
Effectiveness
1
Safety
Recruiting
Van Nuys, CA
18+
All Sexes
Mindfulness-based Dance/movement Therapy (M-DMT)
for Back Pain
Phase-Based Estimates
1
Effectiveness
1
Safety
Recruiting
Philadelphia, PA
18+
All Sexes
Enhanced Acupuncture
for Back Pain
Phase-Based Estimates
1
Effectiveness
1
Safety
Recruiting
New York, NY
65+
All Sexes
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