Islet Transplantation
Islet Transplant Techniques for Chronic Pancreatitis
This trial is testing whether or not it's better to transplant islets into the omentum (a fold of the peritoneum) or leave them in the liver. They will compare islet function in patients to a group of normal volunteers.
Behavioural Intervention
Virtual Reality Therapy for Pancreatitis
This trial aims to test if a home-based virtual reality therapy can help patients with chronic or recurrent pancreatitis pain. The study will use questionnaires and Fitbit data to measure the therapy's impact on
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Trials for Acute Pancreatitis Patients
Behavioural Intervention
Intermittent Fasting for Pancreatitis
This trial is testing intermittent fasting to help people with recurrent acute and chronic pancreatitis. The fasting process releases fatty acids that turn into ketones, providing energy and reducing inflammation and scarring in the pancreas.
Behavioral Intervention
Online Pain Management for Chronic Pancreatitis
This trial aims to help people with chronic pancreatitis who suffer from severe abdominal pain. The study will use an online program to teach self-management techniques to reduce pain and improve quality of life. The goal
Calcineurin Inhibitor
Indomethacin + Tacrolimus to Prevent Post-ERCP Pancreatitis
This trial is testing if taking oral tacrolimus before a specific medical procedure can prevent pancreatitis. The study focuses on patients who are at risk of developing pancreatitis after this procedure. Tacrolimus works by stopping the release of substances in the pancreas that cause inflammation. Tacrolimus has been studied for its potential to prevent pancreatitis after this procedure by reducing inflammation.
Trials for AP Patients
Behavioural Intervention
Intermittent Fasting for Pancreatitis
This trial is testing intermittent fasting to help people with recurrent acute and chronic pancreatitis. The fasting process releases fatty acids that turn into ketones, providing energy and reducing inflammation and scarring in the pancreas.
Behavioral Intervention
Online Pain Management for Chronic Pancreatitis
This trial aims to help people with chronic pancreatitis who suffer from severe abdominal pain. The study will use an online program to teach self-management techniques to reduce pain and improve quality of life. The goal
Calcineurin Inhibitor
Indomethacin + Tacrolimus to Prevent Post-ERCP Pancreatitis
This trial is testing if taking oral tacrolimus before a specific medical procedure can prevent pancreatitis. The study focuses on patients who are at risk of developing pancreatitis after this procedure. Tacrolimus works by stopping the release of substances in the pancreas that cause inflammation. Tacrolimus has been studied for its potential to prevent pancreatitis after this procedure by reducing inflammation.
Trials With No Placebo
Behavioural Intervention
Intermittent Fasting for Pancreatitis
This trial is testing intermittent fasting to help people with recurrent acute and chronic pancreatitis. The fasting process releases fatty acids that turn into ketones, providing energy and reducing inflammation and scarring in the pancreas.
Procedure
ESWL vs SOPIL for Pancreatic Stones
This trial is designed to compare the two techniques for breaking apart stones in the pancreatic duct: extracorporeal shock wave lithotripsy (ESWL) and single operator pancreatoscopy with intracorporeal lithotripsy (SOPIL).
QST for Chronic Pancreatitis
This trial will use a new technique, quantitative sensory testing (QST), to map pain patterns in people with chronic pancreatitis (CP). QST has the potential to improve treatment for CP and may eventually be able to predict response to CP therapies.
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Frequently Asked Questions
Introduction to chronic pancreatitis
What are the top hospitals conducting chronic pancreatitis research?
In the battle against chronic pancreatitis, several top hospitals are leading the charge in groundbreaking clinical trials. Located in Pittsburgh, the University of Pittsburgh Medical Center (UPMC) stands out with four active trials focused on this condition and a total of seven trials conducted to date. UPMC has been at the forefront of chronic pancreatitis research since initiating its first trial in 2010. Meanwhile, at the Medical University of South carolina (MUSC) in Charleston, researchers are actively involved in three ongoing clinical trials for chronic pancreatitis. MUSC has contributed to a total of seven trials overall since their initial exploration into this area began in 2014.
The University of Minnesota also plays an essential role by conducting three active clinical trials for chronic pancreatitis and has completed five such studies over time; they started examining this condition more closely from as recently as 2014. Similarly, Indiana University located in Indianapolis is making progress with two ongoing clinical investigations revolving around chronic pancreatitis after recording only two experiments entirely exploring this field starting from just back then until it's initiation year eight years later- 2018.
Lastly but no less significant is Mayo Clinic situated at Rochester where they currently have two active tests concerning treatments related to patients diagnosed with chronic Pancreatitis while having previously executed four completely dedicated trails beginning from all those years ago-2006 , each representing another step forward towards finding improved solutions for individuals affected by this complex disease.
These pioneering institutions demonstrate not only their commitment to improving outcomes for those living with chronic pancreatitis but also serve as beacons of hope for medical advancements across the nation. The collective efforts carried out within these top hospitals underline that every study contributes valuable knowledge towards unraveling the mysteries surrounding this debilitating condition—bringing us one step closer to effective treatments and ultimately better quality of life for patients worldwide
Which are the best cities for chronic pancreatitis clinical trials?
When it comes to chronic pancreatitis clinical trials, several cities stand out as hubs for research and development. Los Angeles, California leads the way with 8 active trials investigating treatments such as 0.5 mg/kg (0.3125 mL/kg), ERCP with miES, Paricalcitol, and more. Indianapolis, Indiana follows closely behind with 5 ongoing studies focusing on Dose Escalation Level, Quantitative Sensory Test 1, ESWL, and others. Charleston, South carolina along with Pittsburgh, Pennsylvania and Baltimore Maryland all have 4 active trials each exploring various interventions like Experimental Cohort, Bone marrow-derived mesenchymal stem cells,EUS + Pancreatic Endotherapy; Dose Escalation Level; Quantitative Sensory Test 1; ERCP with miES; Healthy Controls; Rectal Indomethacin respectively. These cities offer individuals suffering from chronic pancreatitis access to cutting-edge clinical trials that may bring new hope for better management of this condition.
Which are the top treatments for chronic pancreatitis being explored in clinical trials?
Clinical trials exploring potential treatments for chronic pancreatitis have identified paricalcitol as a notable contender. With one active trial dedicated specifically to chronic pancreatitis, paricalcitol shows promise in potentially alleviating the symptoms and addressing the underlying causes of this condition. First listed in 2023, this treatment is still in its early stages but holds significant potential to make a positive impact on patients' lives affected by chronic pancreatitis.
What are the most recent clinical trials for chronic pancreatitis?
Exciting advancements are being made in the field of chronic pancreatitis, with recent clinical trials offering new possibilities for treatment. One such trial is exploring the use of pirfenidone as a potential therapy for this condition. With both Phase 1 and Phase 2 studies completed, researchers have been able to assess its effectiveness and safety in patients. Another trial focused on dose escalation levels has shown promise in finding optimal dosing strategies for treating chronic pancreatitis. Additionally, rectal indomethacin is being investigated in a Phase 3 study to evaluate its potential benefits for managing symptoms associated with the disease. Lastly, a Phase 4 trial aims to improve our understanding of pancreatitis stages through imaging stratification techniques. These ongoing trials bring hope to individuals living with chronic pancreatitis by offering potential breakthroughs in their care and management.
What chronic pancreatitis clinical trials were recently completed?
Recently, two significant clinical trials investigating potential treatments for chronic pancreatitis have reached completion. In October 2021, AbbVie successfully concluded a trial examining the effectiveness of CREON in managing this challenging condition. Mayo Clinic also completed a trial in July 2020 that explored the use of Indomethacin as a potential therapy for chronic pancreatitis. These important studies contribute to our understanding of treatment options and offer hope for individuals living with this debilitating disease.