Secretin for Pancreatic Function Study

Overseen By Samuel Han, MD

Age: 18+

Sex: Any

Trial Phase: Phase 4

Sponsor: Mayo Clinic

No Placebo Group All trial participants will receive the active study treatment (no placebo)

Prior Safety Data This treatment has passed at least one previous human trial

Compensation: Varies

Number of Visits: Unknown

What You Need to Know Before You Apply

What is the purpose of this trial?

The purpose of this study is to collect pancreas fluid from the duodenum using the endoscopic pancreas function collection method in healthy participants after pancreatic stimulation with human secretin.

Who Is on the Research Team?

Samuel Han, MD

Principal Investigator

Mayo Clinic

Are You a Good Fit for This Trial?

This trial is for healthy individuals who can undergo a procedure to collect pancreatic fluid after stimulation with a drug called human secretin. Specific eligibility details are not provided.

Inclusion Criteria

I am a male or a non-pregnant female.

Participants must be in good health based on medical history (ASA Class 3 or below)

Participants must be willing and able to provide informed consent

Exclusion Criteria

Smokers (cigarette)

I have a history of inflammatory bowel disease.

I have had pancreatitis or other pancreatic conditions.

What Are the Treatments Tested in This Trial?

Interventions

• Secretin

Trial Overview

The study is testing the effect of Secretin (human synthetic) on pancreatic fluid composition in healthy subjects, using an endoscopic method to collect the fluid after drug-induced stimulation.

How Is the Trial Designed?

Group I: Healthy Participants Experimental Treatment 1 Intervention

Healthy participants without pancreatic disease who are undergoing an endoscopic ultrasound for a non-pancreatic indication. This arm will be stratified into 3 age groups: 18-35, 35-45, and 46+ years. Participants will be given a standard dose of intravenous human secretin (0.2 mcg/kg) during the endoscopic ultrasound. During this time, pancreatic fluid will be collected at 5 minutes, 10 minutes, 15 minutes, and 20 minutes after secretin administration.

Who Is Running the Clinical Trial?

Mayo Clinic

Lead Sponsor

Trials

3,427

Recruited

3,221,000+

ChiRhoClin, Inc.

Industry Sponsor

Trials

10

Recruited

9,900+