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Operant Conditioning for Stroke Recovery

N/A
Recruiting
Led By Stacey L DeJong, PhD, PT
Research Sponsored by Stacey Dejong
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Normal function of both upper extremities
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up baseline, before and after up to 8 weeks of operant conditioning and follow up 3 months later
Awards & highlights

Study Summary

This trial will investigate whether operant conditioning can be used to improve motor control in the upper limbs of people who have suffered a stroke.

Who is the study for?
This trial is for individuals with normal upper extremity function, who can consent to participate and are generally healthy. It's suitable for both stroke patients seeking improved motor control and healthy subjects interested in contributing to the research.Check my eligibility
What is being tested?
The study tests if operant conditioning can modify spinal reflexes and corticospinal excitability, potentially improving wrist muscle control. Participants will undergo nerve stimulation while performing a cursor-tracking task to measure changes in motor performance.See study design
What are the potential side effects?
Since this trial involves non-invasive brain stimulation and peripheral nerve stimulation, side effects may include mild discomfort or headache during or after the procedure, but serious side effects are unlikely.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
Select...
Both of my arms work normally.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~baseline, before and after up to 8 weeks of operant conditioning and follow up 3 months later
This trial's timeline: 3 weeks for screening, Varies for treatment, and baseline, before and after up to 8 weeks of operant conditioning and follow up 3 months later for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Muscle Tissue
Motor evoked potential amplitude of target muscle (wrist flexor)
Secondary outcome measures
Action Research Arm Test
Upper Extremity
Maximum H-reflex amplitude of an antagonist muscle (wrist extensor)
+3 more

Trial Design

4Treatment groups
Experimental Treatment
Group I: MEP conditioning - StrokeExperimental Treatment1 Intervention
Operant conditioning of motor evoked potentials in people post-stroke
Group II: MEP conditioning - HealthyExperimental Treatment1 Intervention
Operant conditioning of motor evoked potentials in healthy volunteers
Group III: H-reflex conditioning - StrokeExperimental Treatment1 Intervention
Operant conditioning of H-reflexes in people post-stroke
Group IV: H-reflex conditioning - HealthyExperimental Treatment1 Intervention
Operant conditioning of H-reflexes in healthy volunteers

Find a Location

Who is running the clinical trial?

Stacey DejongLead Sponsor
Roy J. Carver Charitable TrustUNKNOWN
National Center of Neuromodulation for RehabilitationOTHER
10 Previous Clinical Trials
171 Total Patients Enrolled
4 Trials studying Stroke
49 Patients Enrolled for Stroke

Media Library

Operant Conditioning of H-reflexes Clinical Trial Eligibility Overview. Trial Name: NCT03461159 — N/A
Stroke Research Study Groups: H-reflex conditioning - Healthy, H-reflex conditioning - Stroke, MEP conditioning - Healthy, MEP conditioning - Stroke
Stroke Clinical Trial 2023: Operant Conditioning of H-reflexes Highlights & Side Effects. Trial Name: NCT03461159 — N/A
Operant Conditioning of H-reflexes 2023 Treatment Timeline for Medical Study. Trial Name: NCT03461159 — N/A

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Who else is applying?

What state do they live in?
Iowa
What site did they apply to?
University of Iowa
What portion of applicants met pre-screening criteria?
Met criteria
How many prior treatments have patients received?
0
Recent research and studies
Journal of NeuroscienceJournal
Operant Conditioning of a Spinal Reflex Can Improve Locomotion After Spinal Cord Injury in Humans
Thompson, A. K., F. R. Pomerantz, and J. R. Wolpaw. 2013. “Operant Conditioning of a Spinal Reflex Can Improve Locomotion After Spinal Cord Injury in Humans”. Journal of Neuroscience. Society for Neuroscience. doi:10.1523/jneurosci.3968-12.2013.
clinicaltrials.govStudy
Operant Conditioning for Neuromodulation
Stacey Dejong 2018. "Operant Conditioning for Neuromodulation". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT03461159.
All > Stroke > Transcranial Magnetic Stimulation
~2 spots leftby Jun 2024
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