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Behavioral Intervention

Operant Conditioning for Foot Drop Post-Stroke

N/A
Recruiting
Research Sponsored by University of Nevada, Las Vegas
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
At least 6 months following a single, unilateral stroke, resulting in hemiparesis
All subjects will be adults at least 18 years old
Must not have
No other neurological disease or injuries other than the stroke affecting the use of the legs and/or walking
Cerebellar stroke
Timeline
Screening 3 weeks
Treatment Varies
Follow Up before training baseline, after completion of 30 training sessions, and 1 month after the completion of intervention
Awards & highlights

Summary

This trial is studying reflex pathways in the ankle of post-stroke people to improve their foot drop. 5 people are needed, with 40 visits over 4 months.

Who is the study for?
This trial is for adults over 18 who had a stroke at least 6 months ago, resulting in hemiparesis and foot drop. Participants must be able to see computer icons from 4 feet away, follow verbal instructions, walk with or without help despite gait issues due to weak tibialis anterior muscle.Check my eligibility
What is being tested?
The study tests reflex training using operant conditioning on the ankle plantarflexors of individuals with post-stroke hemiparesis. It involves attending 40 sessions over approximately four months to improve walking ability and manage foot drop.See study design
What are the potential side effects?
Since this intervention focuses on behavioral training rather than medication or surgery, side effects are minimal but may include fatigue or discomfort from repetitive exercises during the conditioning sessions.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
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I had a stroke 6 months ago that caused weakness on one side of my body.
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I am at least 18 years old.
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I can walk, but I have difficulty lifting the front part of my foot.

Exclusion Criteria

You may be eligible for the trial if you check “No” for criteria below:
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I have no neurological issues affecting my legs/walking besides stroke.
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I have had a stroke in the cerebellum.
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I have no ear or balance issues not caused by a stroke.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~before training baseline, after completion of 30 training sessions, and 1 month after the completion of intervention
This trial's timeline: 3 weeks for screening, Varies for treatment, and before training baseline, after completion of 30 training sessions, and 1 month after the completion of intervention for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Change in magnitude of reciprocal inhibition

Trial Design

1Treatment groups
Experimental Treatment
Group I: Reciprocal inhibition up conditioningExperimental Treatment1 Intervention
Each participant completes 6 baseline sessions and 30 up conditioning sessions. In the 30 conditioning sessions, the magnitude of reciprocal inhibition in the paretic leg of participants post-stroke will be up conditioned.

Research Highlights

Information in this section is not a recommendation. We encourage patients to speak with their healthcare team when evaluating any treatment decision.
Mechanism Of Action
Side Effect Profile
Prior Approvals
Other Research
Common treatments for Foot Drop include physical therapy, electrical stimulation, and orthotic devices. Physical therapy focuses on strengthening the muscles and improving coordination, which can help restore some degree of normal function. Electrical stimulation works by activating the nerves and muscles in the affected area, promoting muscle contraction and improving muscle strength. Orthotic devices, such as ankle-foot orthoses (AFOs), provide support and maintain proper foot positioning. Operant conditioning, as studied in the trial, aims to modify neural pathways and reflexes to improve motor control and walking ability. This is particularly important for Foot Drop patients as it addresses the underlying neural deficits, potentially leading to more sustainable and long-term improvements in mobility and function.
Use of electrical stimulation and exercise to increase muscle strength in a patient after surgery for cervical spondylotic myelopathy.

Find a Location

Who is running the clinical trial?

University of Nevada, Las VegasLead Sponsor
69 Previous Clinical Trials
13,945 Total Patients Enrolled

Media Library

Operant conditioning (Behavioral Intervention) Clinical Trial Eligibility Overview. Trial Name: NCT05801744 — N/A
Stroke Research Study Groups: Reciprocal inhibition up conditioning
Stroke Clinical Trial 2023: Operant conditioning Highlights & Side Effects. Trial Name: NCT05801744 — N/A
Operant conditioning (Behavioral Intervention) 2023 Treatment Timeline for Medical Study. Trial Name: NCT05801744 — N/A
~2 spots leftby Dec 2025