Bimatoprost for Graves' Eye Disease
Trial Summary
Will I have to stop taking my current medications?
The trial does not specify if you need to stop taking your current medications, but you cannot participate if you are taking steroids.
Is bimatoprost generally safe for human use?
Bimatoprost, used in treatments like Lumigan and Latisse, is generally well tolerated, but some people may experience side effects like mild eye redness, eyelash growth, and itching. There is also a small risk of changes in fat around the eyes, which can be permanent, so it's important to discuss these potential side effects with your doctor.12345
How is the drug bimatoprost unique for treating Graves' Eye Disease?
Bimatoprost is unique because it is a synthetic prostamide that lowers eye pressure by increasing fluid outflow, and it is typically used for glaucoma and ocular hypertension. Its use in Graves' Eye Disease is novel, as it may offer a new approach by leveraging its pressure-lowering effects, which are not standard for this condition.12456
What is the purpose of this trial?
Testing whether Bimatoprost, a topical eye drop used for glaucoma, can be used to induce periorbital fat atrophy in patients with Graves' disease
Research Team
Emily Li, MD
Principal Investigator
Johns Hopkins University
Eligibility Criteria
This trial is for individuals with Graves' Eye Disease who are experiencing bulging eyes (Exophthalmos/Proptosis). Participants should not have active Graves' disease, be pregnant, or be taking steroids.Inclusion Criteria
Exclusion Criteria
Timeline
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants instill Bimatoprost in their more proptotic eye nightly
Follow-up
Participants are monitored for safety and effectiveness after treatment
Treatment Details
Interventions
- Bimatoprost Ophthalmic
Bimatoprost Ophthalmic is already approved in United States, European Union for the following indications:
- Open-angle glaucoma
- Ocular hypertension
- Eyelash hypotrichosis
- Open-angle glaucoma
- Ocular hypertension
- Eyelash hypotrichosis
Find a Clinic Near You
Who Is Running the Clinical Trial?
Johns Hopkins University
Lead Sponsor
University of Washington
Lead Sponsor