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PET Stress Test vs CAC Scan for Coronary Artery Disease (ACCURATE Trial)
N/A
Recruiting
Led By Kirk U Knowlton, MD
Research Sponsored by Intermountain Health Care, Inc.
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 5 years
Awards & highlights
ACCURATE Trial Summary
This trial will compare the cost and effectiveness of two strategies for patients with possible coronary artery disease: a PET stress test or a CAC scan.
Who is the study for?
This trial is for men and women over 50 who may have coronary artery disease, as suggested by chest pain or similar symptoms. They must understand and agree to the study's process. People with known heart conditions, a high calcium score from previous tests, or certain other health issues can't join.Check my eligibility
What is being tested?
The study compares two approaches in patients suspected of having coronary artery disease: one group gets a PET stress test directly while the other follows a 'calcium-first' strategy which could lead to medical management without PET if their calcium levels are low.See study design
What are the potential side effects?
Potential side effects aren't specified here but generally, PET scans involve exposure to radiation and possible allergic reactions to contrast agents used during imaging. Medical management might include medications with various side effects.
ACCURATE Trial Timeline
Screening ~ 3 weeks3 visits
Treatment ~ Varies
Follow Up ~ 5 years
Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~5 years
Treatment Details
Study Objectives
Outcome measures can provide a clearer picture of what you can expect from a treatment.Primary outcome measures
Cost-effectiveness
Non-inferior major adverse cardiac endpoint (MACE) outcomes
ACCURATE Trial Design
2Treatment groups
Experimental Treatment
Group I: Management without stress-imagingExperimental Treatment1 Intervention
Subjects randomized to the CAC-only arm will receive appropriate non-PET driven medical clinical management and follow-up.
Group II: Cardiac PET stress testing and test-dependent managementExperimental Treatment1 Intervention
Subjects randomized to the cardiac PET stress test strategy will receive appropriate subsequent care depending on the outcome of the cardiac PET scan (i.e., depending on whether ischemia is present or not).
Find a Location
Who is running the clinical trial?
Intermountain Health Care, Inc.Lead Sponsor
137 Previous Clinical Trials
1,960,610 Total Patients Enrolled
4 Trials studying Coronary Artery Disease
31,200 Patients Enrolled for Coronary Artery Disease
Kirk U Knowlton, MDPrincipal InvestigatorIntermountain Medical Center
1 Previous Clinical Trials
15 Total Patients Enrolled
Jeffrey L Anderson, MDPrincipal InvestigatorIntermountain Medical Center
2 Previous Clinical Trials
2,615 Total Patients Enrolled
Media Library
Eligibility Criteria:
This trial includes the following eligibility criteria:- I am scheduled for a heart PET/CT scan before my major non-chest surgery.Your calcium score from your most recent heart check is higher than 1.Your doctor thinks you have less than a year to live.I choose not to have a new heart scan or my doctor prefers a PET scan for my heart.You have a previous CAC score higher than 1.I have a history of heart disease, including severe valve issues or heart failure.I am scheduled for a cardiac PET scan to check for heart-related chest pain.I have signs of a possible heart attack shown by high troponin levels or ECG changes.I am 50 years old or older.You have had one or fewer episodes of cardiac assessment before this one.I am getting a heart PET/CT scan to check for reduced blood flow due to my irregular heartbeat.You have a CAC score of 1 or higher from a routine CAC screening.
Research Study Groups:
This trial has the following groups:- Group 1: Management without stress-imaging
- Group 2: Cardiac PET stress testing and test-dependent management
Awards:
This trial has 1 awards, including:- No Placebo-Only Group - All patients enrolled in this study will receive some form of active treatment.
Timeline:
This trial has the following timeline:- Screening: It may take up to 3 Weeks to process to see if you qualify in this trial.
- Treatment: The duration you will receive the treatment varies.
- Follow Ups: You may be asked to continue sharing information regarding the trial for 6 Months after you stop receiving the treatment.
Frequently Asked Questions
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
Are there still opportunities for enrolment in this research endeavor?
"According to the latest data hosted on clinicaltrials.gov, this research study is currently seeking volunteers having been initially posted in November 2019 and most recently revised in August 2022."
Answered by AI
How many participants have enrolled in this experiment?
"Affirmative. Evidenced on clinicaltrials.gov, this research trial is now enlisting participants, which began being advertised to the public on November 19th 2019 and has been updated most recently on August 8th 2022. 2500 people are necessary to be recruited from one medical site."
Answered by AI
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