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Operant Conditioning for Stroke Rehabilitation

Q: Are any neoteric participants being accepted into this research endeavor?

According to the data available on clinicaltrials.gov, this medical trial is still open for participant recruitment and was initially posted on January 13th 2022 before receiving its last edit on May 12th of the same year.

Q: How many participants are currently being considered for this clinical experiment?

Affirmative. Data hosted on clinicaltrials.gov demonstrates that this trial, which was first published on January 13th 2022, is actively seeking participants. About 20 people are required to be enlisted from a single site.

Q: What population is eligible to be part of this clinical research?

This medical trial has allocated 20 vacancies for participants aged 40 to 75 who have had a <a href="https://www.withpower.com/clinical-trials/stroke">stroke</a>. Applicants need to be free of any neurological impairment, and must identify as either male or female.

Q: Does the criteria for this research endeavor extend to those over sixty years of age?

Participants in this clinical study must be aged 40 or older, but not exceeding 75 years of age.

N/A

Recruiting

Led By Jinsook Roh, Ph.D.

Research Sponsored by University of Houston

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

With moderate-to-severe impairments (FMA<45/66);

Without severe spasticity (Modified Ashworth (MA) <4);

Timeline

Screening 3 weeks

Treatment Varies

Follow Up before any training, after the 12th and 24th conditioning sessions, respectively, and 1 and 3 months after the 24th conditioning, respectively

Awards & highlights

Study Summary

This trial will test if muscles represented in the primary motor cortex can be trained to improve movement after stroke.

Who is the study for?

This trial is for chronic stroke survivors aged 40-75 with moderate-to-severe upper limb impairments, who haven't had botulinum toxin in the impaired arm within 3 months. Participants must be stable on current medications and able to undergo transcranial magnetic stimulation (TMS). Those with severe spasticity, metal implants, pacemakers, epilepsy history, cognitive impairment or pregnancy are excluded.Check my eligibility

What is being tested?

The study tests if operant conditioning of motor evoked potentials can change muscle coordination affected by a stroke. It focuses on wrist extensor muscles and aims to induce corticospinal plasticity through TMS targeting a specific muscle group in the brain's primary motor cortex.See study design

What are the potential side effects?

Potential side effects may include discomfort from TMS like headache or scalp pain at the stimulation site. There could also be risks of inducing seizures although this is rare. Muscle fatigue from exercises might occur as well.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

Select...

I have moderate-to-severe physical impairments.

Select...

My muscle stiffness is not severe.

Select...

I can undergo TMS and have a detectable muscle response in my more affected arm.

Select...

My wrist is weak; I can barely move it against gravity.

Select...

I had a stroke in the middle part of my brain.

Select...

My neurological condition has been stable for over 6 months.

Select...

I have no known brain or nerve injuries.

Select...

I am between 40 and 75 years old.

Select...

I am between 40 and 75 years old.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ before any training, after the 12th and 24th conditioning sessions, respectively, and 1 and 3 months after the 24th conditioning, respectively

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~before any training, after the 12th and 24th conditioning sessions, respectively, and 1 and 3 months after the 24th conditioning, respectively

This trial's timeline: 3 weeks for screening, Varies for treatment, and before any training, after the 12th and 24th conditioning sessions, respectively, and 1 and 3 months after the 24th conditioning, respectively for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

Change in Action Research Arm Test (ARAT) score

Change in Fugl-Meyer Assessment (FMA) score

Change in intermuscular coordination patterns (ICoPs)

+1 more

Secondary outcome measures

Change in force errors that occur during isometric wrist force tracking tasks

Trial Design

1Treatment groups

Experimental Treatment

Group I: ECR MEP conditioning - StrokeExperimental Treatment1 Intervention

MEP operant conditioning of ECR in stroke survivors

0 / 9Eligibility criteria met

Find a Location

Who is running the clinical trial?

University of HoustonLead Sponsor

147 Previous Clinical Trials

47,462 Total Patients Enrolled

5 Trials studying Stroke

123 Patients Enrolled for Stroke

National Center of Neuromodulation for RehabilitationOTHER

10 Previous Clinical Trials

211 Total Patients Enrolled

4 Trials studying Stroke

89 Patients Enrolled for Stroke

Jinsook Roh, Ph.D.Principal InvestigatorUniversity of Houston

Media Library

Operant conditioning of motor evoked potentials Clinical Trial Eligibility Overview. Trial Name: NCT05020080 — N/A

Stroke Research Study Groups: ECR MEP conditioning - Stroke

Stroke Clinical Trial 2023: Operant conditioning of motor evoked potentials Highlights & Side Effects. Trial Name: NCT05020080 — N/A

Operant conditioning of motor evoked potentials 2023 Treatment Timeline for Medical Study. Trial Name: NCT05020080 — N/A

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Are any neoteric participants being accepted into this research endeavor?

"According to the data available on clinicaltrials.gov, this medical trial is still open for participant recruitment and was initially posted on January 13th 2022 before receiving its last edit on May 12th of the same year."

Answered by AI

How many participants are currently being considered for this clinical experiment?

"Affirmative. Data hosted on clinicaltrials.gov demonstrates that this trial, which was first published on January 13th 2022, is actively seeking participants. About 20 people are required to be enlisted from a single site."

Answered by AI

What population is eligible to be part of this clinical research?

"This medical trial has allocated 20 vacancies for participants aged 40 to 75 who have had a stroke. Applicants need to be free of any neurological impairment, and must identify as either male or female."

Answered by AI