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Behavioural Intervention
Movement Priming for Stroke Recovery
N/A
Waitlist Available
Led By Sangeetha Madhavan, PT, PhD
Research Sponsored by University of Illinois at Chicago
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial Must have
Single, monohemispheric stroke
Residual hemiparetic gait deficits (e.g., abnormal gait pattern)
Timeline
Screening 3 weeks
Treatment Varies
Follow Up change from baseline to immediately after priming, to 30 minutes after priming, and to 60 minutes after priming.
Awards & highlights
Study Summary
This trial will explore how moving the arms can improve movement and motor skills in people with stroke.
Who is the study for?
This trial is for individuals who have had a single stroke affecting one side of the brain at least 6 months ago and are experiencing walking difficulties. They must be able to perform certain arm movements and not be taking specific medications that affect the brain's activity or increase seizure risk. People with severe cognitive impairment, other neurological disorders, uncontrolled medical conditions, or those who can't follow instructions due to language barriers cannot participate.Check my eligibility
What is being tested?
The study tests how upper limb movement (UL-priming) affects recovery in lower limbs compared to sham priming (just listening to a metronome), electrical brain stimulation (tDCS), or lower limb exercise. Participants will try each method in separate sessions, and researchers will measure changes in their leg function and brain activity.See study design
What are the potential side effects?
Possible side effects may include discomfort from wearing devices used for priming or exercising, skin irritation under electrode pads from tDCS, mild fatigue after sessions, dizziness during physical activities, and rare risks of seizures with electrical stimulation.
Eligibility Criteria
Inclusion Criteria
You may be eligible if you check “Yes” for the criteria belowSelect...
I had a stroke affecting one side of my brain.
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I have difficulty walking due to partial paralysis.
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My arm's movement is limited but I can move it with some help.
Timeline
Screening ~ 3 weeks3 visits
Treatment ~ Varies
Follow Up ~ change from baseline to immediately after priming, to 30 minutes after priming, and to 60 minutes after priming.
Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~change from baseline to immediately after priming, to 30 minutes after priming, and to 60 minutes after priming.
Treatment Details
Study Objectives
Outcome measures can provide a clearer picture of what you can expect from a treatment.Primary outcome measures
Corticomotor excitability using transcranial magnetic stimulation (TMS)
Motor control
Spinal H-reflex excitability using peripheral nerve stimulation (PNS)
Secondary outcome measures
Gait speed
Muscle strength
Trial Design
4Treatment groups
Experimental Treatment
Active Control
Placebo Group
Group I: Upper limb-based movement priming (UL-priming)Experimental Treatment1 Intervention
The upper limb priming task will include rhythmic, bilateral priming involving the movement of at least one major joint in the upper limbs (shoulder, elbow, wrist).
Group II: Stimulation-based priming (Stim priming)Active Control1 Intervention
Participants will receive facilitatory transcranial direct current stimulation (tDCS) through a constant current stimulator.
Group III: Lower limb-based movement priming (LL-priming)Active Control1 Intervention
Participants will perform high-intensity interval-based aerobic exercise on a treadmill or recumbent stepper.
Group IV: Sham primingPlacebo Group1 Intervention
Participants will listen to a 1 Hz metronome for 20 minutes as a form of auditory stimulation during the sham priming session.
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Who is running the clinical trial?
University of Illinois at ChicagoLead Sponsor
608 Previous Clinical Trials
1,559,199 Total Patients Enrolled
18 Trials studying Stroke
2,201 Patients Enrolled for Stroke
Sangeetha Madhavan, PT, PhDPrincipal InvestigatorUniversity of Illinois at Chicago
1 Previous Clinical Trials
50 Total Patients Enrolled
1 Trials studying Stroke
50 Patients Enrolled for Stroke
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Eligibility Criteria:
This trial includes the following eligibility criteria:- I have a history of seizures or epilepsy.I have tumors in my brainstem or cerebellum.You have a score of 2 or higher on the Modified Ashworth Scale.You have a sensitivity or allergy to the skin.I frequently have headaches without a known cause.You have had a concussion in the last 6 months.I had a stroke affecting one side of my brain.I have a skin or scalp condition that might worsen with tDCS treatment.I have difficulty walking due to partial paralysis.You have other brain or nervous system conditions.I experience dizziness or chest pain when active.You had a bad reaction to TMS before.I experience increased sensitivity or pain from touch.I had a stroke more than 6 months ago.I am not taking any medication that affects brain activity or increases seizure risk.You had bad reactions to tDCS before.My arm's movement is limited but I can move it with some help.You scored less than 21 on a test that measures memory and thinking, which means you might have trouble following instructions.You have a pacemaker implanted in your heart.I am taking medication for muscle spasms.I have an injury to my bone, joint, or soft tissue.You did not pass the Physical Activity Readiness Questionnaire (PAR-Q).I have had skull abnormalities or fractures.You have had a skin rash from touching certain substances before.I do not have any untreated serious health conditions.I have metal implants in my head or face.
Research Study Groups:
This trial has the following groups:- Group 1: Sham priming
- Group 2: Upper limb-based movement priming (UL-priming)
- Group 3: Stimulation-based priming (Stim priming)
- Group 4: Lower limb-based movement priming (LL-priming)
Awards:
This trial has 0 awards, including:Timeline:
This trial has the following timeline:- Screening: It may take up to 3 Weeks to process to see if you qualify in this trial.
- Treatment: The duration you will receive the treatment varies.
- Follow Ups: You may be asked to continue sharing information regarding the trial for 6 Months after you stop receiving the treatment.
Frequently Asked Questions
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
Who is the intended audience for participation in this scientific investigation?
"This research project is only accepting candidates who are between 40 and 90 years of age, have suffered a stroke, and must be one of the 50 participants."
Answered by AI
Is the opportunity to participate in this clinical trial still available for those seeking treatment?
"According to the clinicaltrials.gov hosting this study, it is not presently seeking potential participants. This trial was initially posted on June 1st 2023 and last edited on June 15th 2023. However, there are 1082 other medical studies actively recruiting patients across the globe at present."
Answered by AI
Is the age threshold for this research project above 25 years?
"This medical study mandates that participants be between 40 and 90 years of age. There are 40 trials for people below the legal age, while 1047 have been created to accommodate those over 65."
Answered by AI
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