Liposarcoma Clinical Trials 2023

What are Liposarcoma Clinical Trials?

Liposarcoma refers to cancer in the fatty tissue. This particular cancer causes the growth of tumors in various regions of the body, including the abdomen and thigh. Although rare, Liposarcoma is one of the most dangerous cancers as it is malignant, which means that this cancer can spread.

This cancer spreads to other body areas, and once it invades the vital organs, a patient requires immediate treatment.

While the cause of Liposarcoma is not verified, experts believe that the most significant contributors to the disease are a genetic component of mutation that is accelerated by coming into contact with certain mutagens, especially radiation. Research shows that the disease occurs due to a mutation in chromosome 12q13-15 that amplifies the MDM2 and CDK4 genes.

Liposarcoma clinical trials refer to the research being done to study and evaluate the disease, the diagnosis, treatment, and prevention methods.

Why is Liposarcoma Being Studied Through Clinical Trials?

Liposarcoma is malignant cancer that affects around 2000 Americans yearly and makes up one percent of all global cancers. The cancer is not as dangerous if localized, with a mortality rate of 10% within five years of diagnosis. However, if the cancer spreads or reaches an advanced stage, the five-year mortality rate increases to 44%.

Research shows that soft tissue sarcomas likely metastasize in around 50% of patients. Hence, with a high probability rate of developing metastasized or advanced-stage liposarcoma, the need to find a solution to the problem is vital.

Liposarcoma is primarily present in people aged 50 or above. While there's a genetic component to the condition, several mutagenic factors can influence the development of the cancer.

Therefore, researchers around the globe are carrying out liposarcoma clinical trials to study the causes and effects of the disease and evaluate the efficacy of new modes of treatment.

What Are The Types of Treatments Available for Liposarcoma?

Different approaches to treating Liposarcoma depend on the type and stage of liposarcoma cancer. The treatment can also vary, depending on whether the cancer is localized or has metastasized. Research done by Candace L Haddox and Richard Riedel assesses the efficacy and potentiality of different treatments, including:

• Surgical: Involve removing the tumor surrounding the healthy fat tissue.
• Radiation: Involve treating the tumor using high doses of X-ray radiation after surgery to reduce risks of remission.
• Cytotoxic Chemotherapy: Involve using drugs that kill cancer cells, either administered through an injection or as a pill.

What Are Some Recent Breakthrough Clinical Trials For Liposarcoma

In recent years, Liposarcoma has identified several novel therapeutical methods to treat the cancer. In contrast to the previously existing therapies, these treatment methods target the cancer as researchers designed these trials after thoroughly assessing the inherent biology behind the disease. Some of the most recent breakthrough clinical trials for Liposarcoma include:

2018: a liposarcoma clinical trial conducted by Janssen Research and Development to assess the efficacy of marine-derived compounds Trabectedin in treating advanced-stage liposarcoma. In the US, these studies are currently in phase III.

2020: a clinical trial to study the efficacy of immunotherapy Pembrolizumab to stimulate the immune system to fight cancer cells. The study is being conducted by the Sarcoma Alliance for Research and is currently in phase II.