Browse 121 Squamous Cell Carcinoma Medical Studies Across 320 Cities
16 Phase 3 Trial · 1074 Squamous Cell Carcinoma Clinics
What Are Squamous Cell Carcinoma Clinical Trials?
Squamous cell carcinoma (SCC) is one of the most common skin cancers that affect the squamous cells in the skin. Squamous cells are present in the outer layer of the skin called the epidermis and are responsible for the protection of the dermis. These cells often grow and divide continuously. However, uncontrolled growth leads to cancer in the skin.
The leading cause of SCC is UV damage which causes the production of thymine dimers, resulting in DNA damage that leads to cancer. SCC symptoms include wart-like growth on the skin, open sores, and scaly patches.
Squamous cell carcinoma clinical trials consist of research studies conducted on patients to understand the etiology and progression of the disease. Moreover, new SCC clinical trials aim to find better treatment and diagnosis methods for early treatment and improve the overall survival rate.
Why is Squamous Cell Carcinoma Being Studied Through Clinical Trials?
SCC can occur in two forms; cutaneous and metastatic. While cutaneous SCC only affects the top layer of the skin, metastatic SCC can spread to other organs. Moreover, SCC does not only occur in the skin, as squamous cells exist in the cell lining of multiple organs, including the lungs and thyroid. The survival rate for cutaneous SCC is above 95%. However, around half the patients suffering from metastatic SCC die within five years of diagnosis.
SCC is most common in people over the age of 65or those with long-term sun exposure. Moreover, the disease affects males more than females and does not affect a particular racial demographic more than another. In the United States, more than one million people are diagnosed with SCC annually, causing the rate of SCC to increase by 200% in thirty years.
While current treatment methods provide an option, squamous cell clinical trials are being conducted to research better methods of diagnosis and treatment to control the disease as early as possible and with as few side effects as possible.
What Are the Types of Treatment Available for Squamous Cell Carcinoma?
Current treatment methods for SCC have many side effects, with the most common side effect being cosmetic skin changes and nausea caused by chemotherapy. The available treatment methods for SCC include:
What Are Some Recent Breakthrough Clinical Trials For Squamous Cell Carcinoma?
Current clinical trials are being conducted to assess the safety and efficacy of combination therapy for SCC. Some of the recent breakthrough squamous cell carcinoma clinical trials include:
2021: a phase 2 clinical trial (NCT04854499) by Gilead Sciences to study the efficacy of magrolimab, pembrolizumab, docetaxel, 5-FU, cisplatin, carboplatin, and zimberelimab combination therapy in treating squamous cell carcinoma and evaluate the progression-free survival (PFS) rate.
2021: a phase 2 clinical trial (NCT04632433) by Fondazione Melanoma Onlus to assess the neoadjuvant and adjuvant treatment of cutaneous squamous cell carcinoma using cemiplimab which shows anti-tumor activity in patients with stage 3 SCC.