Reviewed by Michael Gill, B. Sc.
25 Squamous Cell Carcinoma Clinical Trials Near Me
Top Hospitals for Squamous Cell Carcinoma Clinical Trials
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Moffitt Cancer Center
6Active Trials
2All Time Trials for Squamous Cell Carcinoma
2008First Squamous Cell Carcinoma Trial
Top Cities for Squamous Cell Carcinoma Clinical Trials
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New York
36Active Trials
Memorial Sloan Kettering Cancer CenterTop Active Site
Squamous Cell Carcinoma Clinical Trials by Phase of Trial
Phase < 1 Squamous Cell Carcinoma Clinical Trials
3Active Squamous Cell Carcinoma Clinical Trials
3Number of Unique Treatments
2Number of Active Locations
11C-GlutamineDiagnostic (fluciclovine F18 PET/CT)[89Zr]Panitumumab Tracer
Squamous Cell Carcinoma Clinical Trials by Age Group
18+ Squamous Cell Carcinoma Clinical Trials
118Active Squamous Cell Carcinoma Clinical Trials
HPV-I VSCCParticipants with locally advanced, unresectable cutaneous squamous cell carcinoma/CSCCPembrolizumabDaRT seeds5% Imiquimod creamPaclitaxelPembrolizumabPembrolizumab
Top Treatments for Squamous Cell Carcinoma Clinical Trials
Treatment Name
Active Squamous Cell Carcinoma Clinical Trials
All Time Trials for Squamous Cell Carcinoma
First Recorded Squamous Cell Carcinoma Trial

What Are Squamous Cell Carcinoma Clinical Trials?

Squamous cell carcinoma (SCC) is one of the most common skin cancers that affect the squamous cells in the skin. Squamous cells are present in the outer layer of the skin called the epidermis and are responsible for the protection of the dermis. These cells often grow and divide continuously. However, uncontrolled growth leads to cancer in the skin.

The leading cause of SCC is UV damage which causes the production of thymine dimers, resulting in DNA damage that leads to cancer. SCC symptoms include wart-like growth on the skin, open sores, and scaly patches.

Squamous cell carcinoma clinical trials consist of research studies conducted on patients to understand the etiology and progression of the disease. Moreover, new SCC clinical trials aim to find better treatment and diagnosis methods for early treatment and improve the overall survival rate.

Why is Squamous Cell Carcinoma Being Studied Through Clinical Trials?

SCC can occur in two forms; cutaneous and metastatic. While cutaneous SCC only affects the top layer of the skin, metastatic SCC can spread to other organs. Moreover, SCC does not only occur in the skin, as squamous cells exist in the cell lining of multiple organs, including the lungs and thyroid. The survival rate for cutaneous SCC is above 95%. However, around half the patients suffering from metastatic SCC die within five years of diagnosis.

SCC is most common in people over the age of 65or those with long-term sun exposure. Moreover, the disease affects males more than females and does not affect a particular racial demographic more than another. In the United States, more than one million people are diagnosed with SCC annually, causing the rate of SCC to increase by 200% in thirty years.

While current treatment methods provide an option, squamous cell clinical trials are being conducted to research better methods of diagnosis and treatment to control the disease as early as possible and with as few side effects as possible.

What Are the Types of Treatment Available for Squamous Cell Carcinoma?

Current treatment methods for SCC have many side effects, with the most common side effect being cosmetic skin changes and nausea caused by chemotherapy. The available treatment methods for SCC include:

  • Cryosurgery: This involves freezing and destroying cancer cells.
  • Photodynamic Therapy: involves using high-energy light energy to remove cancer cells.
  • Electrodesiccation: involves curetting the affected area and burning it using an electric needle.
  • Mohs Surgery: which involves removal of the affected layer.
  • Chemotherapy: which involves chemicals to target and kill cancer cells.
  • Medication: this involves skin creams that contain imiquimod and 5-fluorouracil to treat the affected area.
  • Immunotherapy: involves monoclonal antibody treatment and other chemicals to boost the immune system against cancer cells. Such treatments include atezolizumab and cobimetinib.

What Are Some Recent Breakthrough Clinical Trials For Squamous Cell Carcinoma?

Current clinical trials are being conducted to assess the safety and efficacy of combination therapy for SCC. Some of the recent breakthrough squamous cell carcinoma clinical trials include:

2021: a phase 2 clinical trial (NCT04854499) by Gilead Sciences to study the efficacy of magrolimab, pembrolizumab, docetaxel, 5-FU, cisplatin, carboplatin, and zimberelimab combination therapy in treating squamous cell carcinoma and evaluate the progression-free survival (PFS) rate.

2021: a phase 2 clinical trial (NCT04632433) by Fondazione Melanoma Onlus to assess the neoadjuvant and adjuvant treatment of cutaneous squamous cell carcinoma using cemiplimab which shows anti-tumor activity in patients with stage 3 SCC.

About The Author

Michael Gill preview

Michael Gill - B. Sc.

First Published: October 9th, 2021

Last Reviewed: November 15th, 2022

Michael Gill holds a Bachelors of Science in Integrated Science and Mathematics from McMaster University. During his degree he devoted considerable time modeling the pharmacodynamics of promising drug candidates. Since then, he has leveraged this knowledge of the investigational new drug ecosystem to help his father navigate clinical trials for multiple myeloma, an experience which prompted him to co-found Power Life Sciences: a company that helps patients access randomized controlled trials.