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Flavonoid

Quercetin for Squamous Cell Cancer in Fanconi Anemia

Phase 2
Waitlist Available
Led By Parinda A Mehta, MD
Research Sponsored by Children's Hospital Medical Center, Cincinnati
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Patients ≥2 years
Able to take enteral medication
Timeline
Screening 3 weeks
Treatment Varies
Follow Up up to 30 months
Awards & highlights

Study Summary

This trial is testing whether the supplement quercetin can prevent or delay the development of skin cancer in people with Fanconi anemia, a rare disease that leads to bone marrow failure and a higher risk for certain cancers.

Who is the study for?
This trial is for individuals over 2 years old with Fanconi anemia (FA), who can take medication by mouth. It's not for those pregnant, breastfeeding, at risk of pregnancy without birth control, or have taken antioxidants like quercetin in the last month. People undergoing cancer treatments or with certain liver and kidney conditions, or on digoxin therapy that can't be stopped are also excluded.Check my eligibility
What is being tested?
The study tests if a dietary supplement called Quercetin can prevent or delay Squamous Cell Carcinoma (SCC) in patients with FA. The goal is to reduce the need for harsher treatments like chemotherapy and radiation therapy which are typically used to treat SCC.See study design
What are the potential side effects?
While specific side effects of Quercetin aren't detailed here, as a dietary supplement it could potentially cause digestive issues, headaches, and may interact with medications such as blood thinners and chemotherapy drugs.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
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I am 2 years old or older.
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I can take medicine by mouth.
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I have been diagnosed with Fanconi anemia.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~up to 30 months
This trial's timeline: 3 weeks for screening, Varies for treatment, and up to 30 months for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Reduction of buccal micronuclei

Trial Design

1Treatment groups
Experimental Treatment
Group I: QuercetinExperimental Treatment1 Intervention
All patients will be treated with oral quercetin.
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Quercetin (dietary supplement)
2012
Completed Phase 1
~30

Find a Location

Who is running the clinical trial?

Children's Hospital Medical Center, CincinnatiLead Sponsor
813 Previous Clinical Trials
6,531,494 Total Patients Enrolled
9 Trials studying Fanconi Anemia
212 Patients Enrolled for Fanconi Anemia
Parinda A Mehta, MDPrincipal InvestigatorCincinnati Children's Hosptial Medical Center

Media Library

Quercetin (Flavonoid) Clinical Trial Eligibility Overview. Trial Name: NCT03476330 — Phase 2
Fanconi Anemia Research Study Groups: Quercetin
Fanconi Anemia Clinical Trial 2023: Quercetin Highlights & Side Effects. Trial Name: NCT03476330 — Phase 2
Quercetin (Flavonoid) 2023 Treatment Timeline for Medical Study. Trial Name: NCT03476330 — Phase 2

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Are participants still being sought for this experiment?

"That is correct. The listing on clinicaltrials.gov reveals that the trial is ongoing and has 55 patients at 1 site."

Answered by AI

Has the FDA cleared Quercetin for public consumption?

"There is some data suggesting Quercetin's safety, but none yet attesting to its efficacy. Therefore, it received a score of 2."

Answered by AI

How many people are currently testing this new treatment method?

"Yes, the information on clinicaltrials.gov indicates that this study is presently searching for candidates. The study was first posted on 5/8/2018 and was last updated on 2/1/2022. The study is searching for 55 patients between 1 sites."

Answered by AI

Is Quercetin (dietary supplement) a new topic of research?

"There are 11 ongoing clinical trials for Quercetin (dietary supplement) at the moment, with 0 Phase 3 trials. Most of these studies are taking place in Montreal, Quebec; however, there are 11 locations total running tests for Quercetin (dietary supplement)."

Answered by AI
~10 spots leftby Oct 2025