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Trials for Kidney Cancer Patients
Tyrosine Kinase Inhibitor
Pembrolizumab + Cabozantinib for Kidney Cancer
This trial tests a combination of two drugs, pembrolizumab and cabozantinib, in patients with advanced kidney cancer. Pembrolizumab boosts the immune system to fight cancer, and cabozantinib stops cancer cells from growing. The goal is to find the best dose and see how well the combination works. Cabozantinib was approved for the treatment of advanced kidney cancer after other treatments.
Checkpoint Inhibitor
Nivolumab + Cabozantinib for Kidney Cancer
This trial will test whether a combination of nivolumab and cabozantinib is safe and effective in treating people with previously untreated advanced or metastatic renal cell carcinoma, compared to sunitinib.
PD-L1 Inhibitor
Immune Checkpoint Inhibitors + Axitinib for Kidney Cancer
This trial is testing a new drug combination for patients with advanced kidney cancer that can't be removed by surgery. The treatment aims to stop the cancer by blocking its blood supply and boosting the immune system. The combination of atezolizumab and bevacizumab has shown promise in treating advanced kidney cancer by helping patients live longer without the disease worsening.
Trials for Kidney Cell Carcinoma Patients
Tyrosine Kinase Inhibitor
Pembrolizumab + Cabozantinib for Kidney Cancer
This trial tests a combination of two drugs, pembrolizumab and cabozantinib, in patients with advanced kidney cancer. Pembrolizumab boosts the immune system to fight cancer, and cabozantinib stops cancer cells from growing. The goal is to find the best dose and see how well the combination works. Cabozantinib was approved for the treatment of advanced kidney cancer after other treatments.
Checkpoint Inhibitor
Nivolumab + Cabozantinib for Kidney Cancer
This trial will test whether a combination of nivolumab and cabozantinib is safe and effective in treating people with previously untreated advanced or metastatic renal cell carcinoma, compared to sunitinib.
PD-L1 Inhibitor
Immune Checkpoint Inhibitors + Axitinib for Kidney Cancer
This trial is testing a new drug combination for patients with advanced kidney cancer that can't be removed by surgery. The treatment aims to stop the cancer by blocking its blood supply and boosting the immune system. The combination of atezolizumab and bevacizumab has shown promise in treating advanced kidney cancer by helping patients live longer without the disease worsening.
Trials With No Placebo
Tyrosine Kinase Inhibitor
Pembrolizumab + Cabozantinib for Kidney Cancer
This trial tests a combination of two drugs, pembrolizumab and cabozantinib, in patients with advanced kidney cancer. Pembrolizumab boosts the immune system to fight cancer, and cabozantinib stops cancer cells from growing. The goal is to find the best dose and see how well the combination works. Cabozantinib was approved for the treatment of advanced kidney cancer after other treatments.
Checkpoint Inhibitor
Nivolumab + Cabozantinib for Kidney Cancer
This trial will test whether a combination of nivolumab and cabozantinib is safe and effective in treating people with previously untreated advanced or metastatic renal cell carcinoma, compared to sunitinib.
Radiation
SABR for Kidney Cancer
This trial is testing whether a certain kind of radiation can help extend the amount of time patients with a certain kind of kidney cancer live without their disease getting worse, and whether it can delay the need for systemic therapy.
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Frequently Asked Questions
Introduction to metastatic renal cell carcinoma
What are the top hospitals conducting metastatic renal cell carcinoma research?
Metastatic renal cell carcinoma, a type of kidney cancer that has spread to other parts of the body, poses significant challenges for patients and researchers alike. In Dallas, UT Southwestern Medical Center is leading the charge with three active clinical trials focused specifically on metastatic renal cell carcinoma. While they may not have conducted any previous trials in this area, their commitment to finding new treatments and improving outcomes is evident. Similarly, M D Anderson Cancer Center in Houston is dedicated to advancing the field with two ongoing trials targeting this aggressive form of kidney cancer. Fox Chase Cancer Center in Philadelphia also joins the efforts with two active metastatic renal cell carcinoma trials aimed at providing hope for patients facing this complex disease.
Notably, Beth Israel Deaconess Medical Center in Boston stands out as another institution actively conducting two clinical trials for metastatic renal cell carcinoma. This innovative research contributes to our understanding of how to effectively combat advanced kidney cancer and improve patient prognosis.
Finally, Dana Farber Cancer Institute in Boston demonstrates its dedication by engaging in two ongoing clinical trials specifically tailored towards metastatic renal cell carcinoma treatment options. These esteemed institutions across different geographical locations unite their expertise and resources toward developing novel therapies that can potentially transform lives affected by this challenging condition.
Although these hospitals have yet to complete any past clinical studies related to metastatic renal cell carcinoma – indicating an urgent need for further investigation – their current endeavors exemplify a collective commitment among medical professionals nationwide striving relentlessly towards finding effective treatments for those battling this formidable disease.
Which are the best cities for metastatic renal cell carcinoma clinical trials?
In the realm of metastatic renal cell carcinoma clinical trials, certain cities emerge as prominent hubs for research and innovative treatments. Boston, Massachusetts takes the lead with 11 active trials investigating promising options like Nivolumab, TAK-228, and Cabozantinib. Dallas, Texas follows closely behind with 6 ongoing studies focusing on interventions such as Nivolumab, MRI with ASL, and Stereotactic ablative body radiation (SABR). New york City also hosts 6 active trials exploring treatments like Nivolumab, Cabozantinib, and Avelumab. Additionally, Chicago in Illinois conducts 6 clinical trials investigating Arm A (Pazopanib), TAK-228, and Cabozantinib. Lastly, Houston in Texas encompasses 5 active trials studying Nivolumab along with Radiation therapy (Control Arm) and Stereotactic Body Radiation Therapy. These cities represent leading centers for metastatic renal cell carcinoma research that offer patients access to cutting-edge clinical trials driving advancements in care for better outcomes.
Which are the top treatments for metastatic renal cell carcinoma being explored in clinical trials?
Metastatic renal cell carcinoma is a challenging disease, but ongoing clinical trials offer hope for improved treatments. Among the top contenders are:
- Daratumumab: Currently being tested in six active trials for metastatic renal cell carcinoma.
- Belantamab mafodotin: Showing promise with four ongoing clinical trials dedicated to this type of cancer.
- Lenalidomide: Also under investigation in three active studies for metastatic renal cell carcinoma. With each trial, researchers inch closer to finding more effective therapies and improving outcomes for patients battling this devastating condition.
What are the most recent clinical trials for metastatic renal cell carcinoma?
Exciting advancements are being made in the field of metastatic renal cell carcinoma, with recent clinical trials presenting promising options for patients. Among them is Arm 2, a Phase 1 trial evaluating the efficacy of nivolumab, ipilimumab, and camu camu in treating this condition. Another notable study is Arm A, a Phase 2 trial that explores the combination of RO7247669 and Axitinib as a potential treatment approach. Additionally, Stereotactic Body Radiation Therapy has shown encouraging results in Phase 2 trials for metastatic renal cell carcinoma. Moreover, Cabozantinib and 89Zr-DFO-Atezolizumab have also demonstrated significant potential in their respective Phase 2 studies. These novel therapies offer hope to patients facing this challenging diagnosis and may pave the way towards improved outcomes.
What metastatic renal cell carcinoma clinical trials were recently completed?
Recently completed clinical trials have made significant strides in advancing the treatment options for metastatic renal cell carcinoma. Notably, a trial sponsored by Pfizer Inc., concluded in July 2021, exploring the efficacy of sunitinib plus atezolizumab compared to standard-of-care sunitinib alone. In another ground-breaking study, Merck Sharp & Dohme Corp. completed a trial investigating pembrolizumab as an adjuvant therapy for patients with resected high-risk renal cell carcinoma in May 2021. These recent advancements underscore the commitment of researchers and pharmaceutical companies to finding innovative solutions against metastatic renal cell carcinoma and offer hope for improved outcomes for patients battling this aggressive form of cancer.