Risk-Directed Therapy After Surgery for Throat Cancer
(MINT Trial)
What You Need to Know Before You Apply
What is the purpose of this trial?
The overarching goal of the MINT trial is to reduce treatment-related toxicity while maintaining efficacy. Patients with HPV-related oropharyngeal squamous cell carcinoma (OPSCC) will undergo resection of the primary tumor site and involved/at risk regional neck nodes.
Will I have to stop taking my current medications?
The trial information does not specify whether you need to stop taking your current medications. It's best to discuss this with the trial coordinators or your doctor.
Is the treatment generally safe for humans?
The research articles focus on outcomes and complications related to head and neck surgery and radiotherapy, but they do not provide specific safety data for the treatments like Cisplatin or Intensity Modulated Proton Therapy. However, these treatments have been used in various conditions, and their safety profiles are generally well-documented in medical literature.12345
How does the treatment 'Risk-Directed Therapy After Surgery for Throat Cancer' differ from other treatments for this condition?
This treatment is unique because it involves tailoring post-surgery therapy based on individual risk factors, potentially combining surgery with radiation or chemotherapy to improve outcomes, especially for high-risk patients. Traditional treatments often use a one-size-fits-all approach, whereas this method aims to optimize therapy based on specific patient needs and risk profiles.678910
What data supports the effectiveness of the treatment after surgery for throat cancer?
Research shows that postoperative radiation therapy can improve local control of cancer in the throat area, although it may not significantly impact overall survival. This suggests that combining surgery with radiation might help reduce the chance of cancer coming back in the treated area.1112131415
Who Is on the Research Team?
Douglas R. Adkins
Principal Investigator
Washington University School of Medicine
Are You a Good Fit for This Trial?
The MINT trial is for adults with HPV-related oropharyngeal squamous cell carcinoma stages I-III, who can undergo surgery via a transoral approach. Participants must have proper kidney function, no recent invasive cancers (with some exceptions), and not be pregnant. They should agree to use contraception and have an ECOG Performance Status of 0-2.Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Surgery
Standard of care surgery involving resection of the primary tumor and management of cervical lymph nodes
Post-operative Adjuvant Therapy
Participants receive post-operative adjuvant therapy, including radiation and possibly chemoradiation, depending on risk factors
Follow-up
Participants are monitored for safety and effectiveness after treatment
What Are the Treatments Tested in This Trial?
Interventions
- Cisplatin
- Intensity modulated proton therapy
- Surgery
Find a Clinic Near You
Who Is Running the Clinical Trial?
Washington University School of Medicine
Lead Sponsor