SCLC Clinical Trials
Here are the 6 most popular medical studies for sclc
Monoclonal Antibodies
BI 764532 for Small Cell Lung Cancer
This trial is for adults with advanced small-cell lung cancer & neuroendocrine tumours. It tests 2 doses of BI 764532, an antibody-like molecule, to see if it shrinks tumours & is safe & tolerable. Participants visit the study site regularly to monitor safety & record effects.
Popular filter options for sclc trials
Metastatic Small Cell Lung Cancer Clinical Trials
View 70 metastatic small cell lung cancer medical studies.
Checkpoint Inhibitor
Immunotherapy + Chemotherapy for Small Cell Lung Cancer
This trial will compare two immunotherapy treatments for small cell lung cancer. The first treatment is a combination of pembrolizumab/vibostolimab with chemotherapy. The second treatment is a combination of atezolizumab with chemotherapy. The study will measure overall survival rates to see if the first treatment is superior to the second.
PD-1/PD-L1 Inhibitor
Pembrolizumab Combinations for Small Cell Lung Cancer
This trial will study the safety and efficacy of pembrolizumab in combination with investigational agents in people with anti-PD-1/PD-L1 refractory ES-SCLC who need second-line treatment. The trial will have two parts: a safety lead-in to determine safety and tolerability for experimental combinations of investigational agents without an established recommended phase 2 dose (RP2D), and an efficacy evaluation.
ALK Positive Clinical Trials
View 10 ALK positive medical studies.
Enzyme Depletion
ADI-PEG 20 + Chemotherapy for Lung Cancer
This trial tests a 3-drug combo to treat lung cancer that has progressed on frontline treatment; first, a phase I will test different doses, then phase II will use the recommended dose to assess efficacy.
Tyrosine Kinase Inhibitor
Erlotinib for Non-Small Cell Lung Cancer
This trial compares erlotinib hydrochloride to observation in treating patients with resected stage IB-IIIA non-small cell lung cancer. Erlotinib hydrochloride may stop tumor cell growth by blocking enzymes needed for cell growth.
Tyrosine Kinase Inhibitor
Alectinib vs Crizotinib for Non-Small Cell Lung Cancer
This trial is testing whether a new drug, alectinib, is better than the current standard of care, crizotinib, for people with treatment-naive ALK-positive advanced NSCLC. Participants will be given either drug BID until disease progression or unacceptable toxicity.
EGFR Positive Clinical Trials
View 9 EGFR positive medical studies.
Enzyme Depletion
ADI-PEG 20 + Chemotherapy for Lung Cancer
This trial tests a 3-drug combo to treat lung cancer that has progressed on frontline treatment; first, a phase I will test different doses, then phase II will use the recommended dose to assess efficacy.
Protein Kinase Inhibitor
Targeted Therapy for Lung Cancer
This trial is testing whether it is possible to analyze the genes of patients with lung cancer and cancers of the thymus in order to provide personalized treatment with drugs that target the specific gene abnormalities.
Tyrosine Kinase Inhibitor
Erlotinib for Non-Small Cell Lung Cancer
This trial compares erlotinib hydrochloride to observation in treating patients with resected stage IB-IIIA non-small cell lung cancer. Erlotinib hydrochloride may stop tumor cell growth by blocking enzymes needed for cell growth.
Phase 3 Small Cell Lung Cancer Clinical Trials
View 70 phase 3 small cell lung cancer medical studies.
Checkpoint Inhibitor
Immunotherapy + Chemotherapy for Small Cell Lung Cancer
This trial will compare two immunotherapy treatments for small cell lung cancer. The first treatment is a combination of pembrolizumab/vibostolimab with chemotherapy. The second treatment is a combination of atezolizumab with chemotherapy. The study will measure overall survival rates to see if the first treatment is superior to the second.
Cancer Vaccine
Botanical Supplement for Lung Cancer
This trial is testing whether a dietary supplement consisting of botanicals with known anti-cancer and/or immune-enhancing properties can prolong the survival time of stage IIIB/IV non-small cell lung cancer patients. The supplement will be given to patients in a double-blind fashion, meaning that neither the patients nor the trial staff will know who is receiving the supplement and who is receiving a placebo.
Immunomodulator
Talactoferrin for Non-Small Cell Lung Cancer
The purpose of the study is to determine whether the combination of talactoferrin, carboplatin and paclitaxel improves progression free survival and overall survival in patients with non-small cell lung cancer compared to the combination of paclitaxel and carboplatin alone
Alkylating agents
Radiation + Chemotherapy for Small Cell Lung Cancer
This trial is testing different radiation therapy regimens to see which is more effective in treating patients with limited-stage small cell lung cancer when given together with chemotherapy.
Small Cell Lung Cancer Clinical Trials With No Placebo
View 70 small cell lung cancer medical studies that do not have a placebo group.
Alkylating agents
Chemotherapy + Allopurinol + Mycophenolate for Small Cell Lung Cancer
This trial is testing whether adding mycophenolate mofetil and allopurinol to chemotherapy drugs used for relapsed small cell lung cancer will improve outcomes compared to using other single agent chemotherapy drugs.
PD-1/PD-L1 Inhibitor
Pembrolizumab Combinations for Small Cell Lung Cancer
This trial will study the safety and efficacy of pembrolizumab in combination with investigational agents in people with anti-PD-1/PD-L1 refractory ES-SCLC who need second-line treatment. The trial will have two parts: a safety lead-in to determine safety and tolerability for experimental combinations of investigational agents without an established recommended phase 2 dose (RP2D), and an efficacy evaluation.
View More Sclc Trials
See another 39 medical studies focused on sclc.
Frequently Asked Questions
Introduction to sclc
What are the top hospitals conducting sclc research?
When it comes to cutting-edge clinical trials in the realm of small cell lung cancer (SCLC), several top hospitals are leading the charge. Memorial Sloan Kettering Cancer Center, located in New york City, is at the forefront with seven active SCLC trials and a total of 23 completed trials dedicated to this aggressive form of lung cancer. Since their first recorded trial in 2007, they have been committed to pushing boundaries and seeking innovative treatment options for patients. Washington University School of Medicine in Saint Louis also deserves recognition, boasting six ongoing SCLC trials and an impressive record of 24 previous trials dating back to their inaugural study in 1992.
Meanwhile, down south at Moffitt Cancer Center in Tampa, researchers are making significant strides as well. With six active SCLC trials and 18 past studies under their belt since initiating their first trial on this condition back in 2008, they demonstrate dedication towards improving patient outcomes. PCR Oncology based in Arroyo Grande may be smaller-scale comparatively but plays a vital role with six current SCLC clinical trials; although they have only conducted five all-time investigations since recording its maiden trial on sclc cases In2007 proving every effort made towards understanding this disease is valuable.
Lastly yet importantly,the Lewis Cancer and Research Pavilion at Saint Joseph's/Candler situatedin Savannah seeks contribution through conducting six ongoing tests which adds over previous nine held experiments tracingback ten years ago till when it started participating from year2008 into such widespread medical research.The efforts by these top hospitals indicate not only progress but hope for those affected by small cell lung cancer worldwide.Through each trial conducted we edge closer toward unravelling mysteries surrounding treatments which ensure brighter future for countless patients suffering from this deadly condition
Which are the best cities for sclc clinical trials?
When it comes to small cell lung cancer (SCLC) clinical trials, several cities stand out as key players in research and development. Anchorage, Alaska leads the pack with 28 active trials focusing on promising treatments such as Pembrolizumab, Erlotinib Hydrochloride, and Cisplatin. Following closely behind is Los Angeles, California with 27 ongoing studies investigating similar interventions like Pembrolizumab and Erlotinib Hydrochloride. Houston, Texas also plays a significant role in SCLC research with 25 active trials exploring innovative approaches such as Local Consolidation Therapy and the NovoTTF-200M device. These cities offer individuals diagnosed with SCLC access to cutting-edge clinical trials that may pave the way for improved treatment options and outcomes.
Which are the top treatments for sclc being explored in clinical trials?
In the realm of small cell lung cancer (SCLC) research, several treatments are currently under investigation in clinical trials. Leading the pack is pembrolizumab, a formidable contender with 10 ongoing trials and a history of 26 all-time SCLC trials since its debut in 2014. Another noteworthy player is durvalumab, making waves with three active trials and an impressive track record of 33 all-time SCLC trials since its introduction in 2016. Additionally, stereotactic radiosurgery has emerged as a newcomer on the scene, showing promise with two active trials and three total SCLC trials recorded since its first listing in 2020. As researchers delve deeper into these potential breakthroughs, new avenues for treating SCLC continue to emerge on the horizon.
What are the most recent clinical trials for sclc?
Promising advancements in the field of small cell lung cancer (SCLC) treatment have emerged through recent clinical trials. One notable trial investigates the efficacy of cemiplimab, a novel therapeutic approach for SCLC patients. This Phase 2 study offers hope for improved outcomes and enhanced quality of life. Additionally, ongoing research focuses on dose-finding strategies in non-small cell lung cancer (NSCLC), aiming to adapt them to benefit individuals with SCLC as well. Furthermore, DB-1311 has shown potential as a treatment option through its dual-phase investigation encompassing both Phase 1 and Phase 2 trials. Another experimental drug, LB2102, is currently being evaluated in a Phase 1 trial for its effectiveness against SCLC. Tocilizumab also presents promise as it undergoes combined Phase 1 and Phase 2 testing towards developing innovative treatment options for this aggressive form of lung cancer. These groundbreaking studies mark significant steps forward in the fight against SCLC and offer renewed optimism to those affected by this disease.
What sclc clinical trials were recently completed?
Several notable clinical trials evaluating treatments for small cell lung cancer (SCLC) have recently concluded, offering valuable insights into potential therapeutic options. In July 2021, BeiGene's trial investigating the effectiveness of Ociperlimab concluded successfully. Another significant trial was completed in March 2021 by EMD Serono Research & Development Institute, Inc., examining the efficacy of Berzosertib. These recent advancements contribute to our understanding and bring hope to patients battling SCLC.