This trial is testing a combination of a gene therapy and an approved cancer immunotherapy in people with recurrent or metastatic cancers, to see if it is safe and effective.
The treatment being studied, Ad-p53, is used to treat Lymphoma. This treatment is different from others because it involves immunotherapy. Ad-p53 has been approved by the FDA for a different condition, so the researchers know it is safe. Because this is a new use for the treatment, the researchers want to make sure it is effective. To do this, they will compare how well patients who receive Ad-p53 do to similar patients who do not receive the treatment. Because Ad-p53 has been approved for a different condition, the researchers know it is safe. Because this is a new use