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Cholinergic Antagonist for Postmenopausal Cognitive Decline (CHAMP Trial)
CHAMP Trial Summary
This trial will study how changes in hormones after menopause may interact with the cholinergic system (which is involved in memory and other cognitive functions) to influence a woman's risk for cognitive decline.
CHAMP Trial Eligibility Criteria
Inclusion Criteria
You may be eligible if you check “Yes” for the criteria belowCHAMP Trial Timeline
Treatment Details
Study Objectives
Outcome measures can provide a clearer picture of what you can expect from a treatment.CHAMP Trial Design
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Who is running the clinical trial?
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- I am a woman aged between 50 and 70.Your blood pressure is higher than 160/100 without taking any medication for it.I have asthma or COPD.I have an overactive thyroid.I have a serious heart condition.I have an active stomach ulcer.I am not taking any medications that are not allowed in this study.I have gone through menopause.I have epilepsy.Your IQ is higher than 80, which means it is in the normal range.I only have mild high blood pressure, no other heart conditions.You do not have any untreated or ongoing serious mental health or thinking problems.People who do not smoke.I haven't taken hormone therapy or related medications for a year.You currently have a mental health condition that has not been treated or improved.You perform well on tests that measure your brain function.I have been treated with chemotherapy for cancer.I have a thyroid condition that hasn't been treated.You have memory or thinking problems, as shown by specific tests.I am in good physical health.
- Group 1: Placebo Challenge
- Group 2: Mecamylamine Challenge
- No Placebo-Only Group - All patients enrolled in this study will receive some form of active treatment.
- Screening: It may take up to 3 Weeks to process to see if you qualify in this trial.
- Treatment: The duration you will receive the treatment varies.
- Follow Ups: You may be asked to continue sharing information regarding the trial for 6 Months after you stop receiving the treatment.
Frequently Asked Questions
Are individuals still able to participate in this experiment?
"The clinical trial, posted on March 15th 2020 and recently updated on the 23rd of March 2022, is currently recruiting participants."
Could I potentially become a subject in this research project?
"This medical research is in search of 120 elderly patients (aged 50-70) with Alzheimer's disease. In addition to this, women must meet further criteria like post menopause, non smoking status, abstinence from certain medications for 1 year or more and normal IQ score & neuropsychological test performance. Furthermore they should not have any untreated physical/mental health issues at the time of enrollment."
To what extent has enrollment in this investigation grown?
"Yes, the information hosted on clinicaltrials.gov reflects that this medical experiment is still welcoming participants. It was initially announced on March 15th of 2020 and its most recent update came about on March 23rd 2022. Presently, 120 patients must be recruited from two separate sites."
Is eligibility for this study limited to people under the age of 25?
"According to the prerequisites for enrolment, patients must be between 50 and 70 years old in order to participate."
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