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Cell Therapy
Intrauterine administration of hCG-activated peripheral blood mononuclear cells for Female Infertility
N/A
Waitlist Available
Research Sponsored by Fertilys
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up after 48 hours of culture
Awards & highlights
Study Summary
This trial is testing whether giving extra immune cells to people with fertility issues can help them get pregnant and carry to term.
Eligible Conditions
- Female Infertility
Timeline
Screening ~ 3 weeks3 visits
Treatment ~ Varies
Follow Up ~ after 48 hours of culture
Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~after 48 hours of culture
Treatment Details
Study Objectives
Outcome measures can provide a clearer picture of what you can expect from a treatment.Primary outcome measures
Clinical pregnancy rate
Embryo implantation rate (biochemical pregnancy)
Secondary outcome measures
Cytokines (LIF, IL-6, IL-10, TNFα, FGF-2, VEGF, IL-8) quantification by ELISA in PBMC culture medium at Day 2
Peripheral blood mononuclear cells populations (PBMC) distribution at Day 0
Peripheral blood mononuclear cells populations distribution at Day 2
Trial Design
3Treatment groups
Experimental Treatment
Active Control
Group I: Recurrent miscarriageExperimental Treatment1 Intervention
Group II: Recurrent implantation failuresExperimental Treatment1 Intervention
Group III: No recurrent implantation failureActive Control1 Intervention
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Intrauterine administration of hCG-activated peripheral blood mononuclear cells
2017
N/A
~430
Find a Location
Who is running the clinical trial?
Centre hospitalier de l'Université de Montréal (CHUM)OTHER
367 Previous Clinical Trials
129,717 Total Patients Enrolled
FertilysLead Sponsor
3 Previous Clinical Trials
675 Total Patients Enrolled
Media Library
Eligibility Criteria:
This trial includes the following eligibility criteria:- Women who require donated eggs or sperm to become pregnant.Women with a condition where their immune system attacks their own body.Women who have diabetes.
Research Study Groups:
This trial has the following groups:- Group 1: Recurrent miscarriage
- Group 2: Recurrent implantation failures
- Group 3: No recurrent implantation failure
Awards:
This trial has 1 awards, including:- No Placebo-Only Group - All patients enrolled in this study will receive some form of active treatment.
Timeline:
This trial has the following timeline:- Screening: It may take up to 3 Weeks to process to see if you qualify in this trial.
- Treatment: The duration you will receive the treatment varies.
- Follow Ups: You may be asked to continue sharing information regarding the trial for 6 Months after you stop receiving the treatment.
Female Infertility Patient Testimony for trial: Trial Name: NCT04753736 — N/A
Frequently Asked Questions
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
Are there still slots available for participants in this experiment?
"The latest information on clinicaltrials.gov states that this trial, which was initially posted in September of 2021, is no longer seeking participants at the current time. However, there are still 245 other trials actively enrolling patients."
Answered by AI
Who else is applying?
What state do they live in?
California
Virginia
Pennsylvania
Other
How old are they?
18 - 65
What site did they apply to?
Fertilys
What portion of applicants met pre-screening criteria?
Met criteria
Did not meet criteria
How many prior treatments have patients received?
3+
2
Why did patients apply to this trial?
I've been trying to have an IVF but it seems that all is fine but I have repeated implantation failures.
PatientReceived no prior treatments
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