Sufficient physical activity for Sterility, Female

Phase-Based Progress Estimates
1
Effectiveness
1
Safety
UCSF Medical Center at Mission Bay, San Francisco, CA
Sterility, Female+1 More
Sufficient physical activity - Behavioral
Eligibility
18 - 65
Female
Eligible conditions
Select

Study Summary

This study is evaluating whether physical activity during fertility treatment has any impact on mental health or clinical outcomes.

See full description

Eligible Conditions

  • Sterility, Female

Treatment Effectiveness

Study Objectives

This trial is evaluating whether Sufficient physical activity will improve 3 primary outcomes and 8 secondary outcomes in patients with Sterility, Female. Measurement will happen over the course of 2 weeks.

10 months
Live Birth Rate
14 days
Anxiety/Depression During Treatment based on Patient-Reported Outcomes Measurement Information System Short Form (PROMIS-SF) Depression 4a and Anxiety 4a
Stress During Treatment based on daily end of day stress item
2 weeks
Cancellation Rate
4 months
Treatment continuation rate
4 weeks
Blastulation Rate
Change in Stress during treatment based upon Perceived Stress Scale (PSS)-14
Fertilization Rate
Number of mature oocytes retrieved
6 weeks
Clinical Pregnancy Rate
Ovarian Torsion

Trial Safety

Trial Design

4 Treatment Groups

Usually Active- Decrease
1 of 4
Usually Insufficiently Inactive- Maintenance
1 of 4
Usually Active- Maintenance
1 of 4
Usually Insufficiently Inactive- Increase
1 of 4
Active Control
Experimental Treatment

This trial requires 600 total participants across 4 different treatment groups

This trial involves 4 different treatments. Sufficient Physical Activity is the primary treatment being studied. Participants will be divided into 2 treatment groups. There is no placebo group. The treatments being tested are not being studied for commercial purposes.

Usually Active- Maintenance
Behavioral
Participants who usually meet or exceed recommended levels of physical activity who will be asked to maintain usual level of activity during stimulation.
Usually Insufficiently Inactive- Increase
Behavioral
Participants who are usually inactive who will be asked to try to increase activity to the recommended level during stimulation.
Usually Active- Decrease
Behavioral
Participants who usually meet or exceed recommended levels of physical activity who will be asked to minimize activity during stimulation.
Usually Insufficiently Inactive- Maintenance
Behavioral
Participants who are usually inactive who will be asked to maintain inactivity during stimulation.

Trial Logistics

Trial Timeline

Approximate Timeline
Screening: ~3 weeks
Treatment: Varies
Reporting: 10 months
This trial has the following approximate timeline: 3 weeks for initial screening, variable treatment timelines, and roughly 10 months for reporting.

Closest Location

UCSF Medical Center at Mission Bay - San Francisco, CA

Eligibility Criteria

This trial is for female patients between 18 and 65 years old. There are 3 eligibility criteria to participate in this trial as listed below.

Mark “yes” if the following statements are true for you:
English speaking/reading
Patient at the Center for Reproductive Health, University of California San Francisco
First ovarian stimulation cycle for egg freezing or for in vitro fertilization

Patient Q&A Section

What causes infertility?

"Sexually transmitted diseases are the number one obstacle in achieving pregnancy. Women with sexually transmitted infections are most at-risk for infertility. The use of barrier methods and hormonal contraception decreases the risk of acquiring infection. It is therefore necessary to implement these methods as a first line in infertile couples since they are the largest contributors to infertility. In recent years, the introduction of ART and ICSI is a valuable option for the treatment of infertility in selected patients. Patients with an ICSI history and a history of treatment of a sexually transmitted infection are at highest risk for developing infertility. However, the risk of infertility can be reduced dramatically in patients who have used barrier methods." - Anonymous Online Contributor

Unverified Answer

What is infertility?

"Infertility is any form of failure to produce biologically childbearing capability in a woman. For male infertility to be diagnosed, it must result in 12 month infertility.\n" - Anonymous Online Contributor

Unverified Answer

What are common treatments for infertility?

"Treatments for infertility include multiple therapies such as FSH stimulation, IUI, assisted reproductive technology (ART) such as in vitro fertilization (IVF) and intrauterine insemination. Moreover, infertility is sometimes treated with medications such as hormone therapy.\n" - Anonymous Online Contributor

Unverified Answer

What are the signs of infertility?

"Signs include the inability to fertilise the ovum, unexplained infertility, abnormal cervical smear and ovarian failure. This can be as early as the pre-ovulatory cycle and as late as the post-ovulatory cycle." - Anonymous Online Contributor

Unverified Answer

How many people get infertility a year in the United States?

"About 1 in 19 boys and 1 in 9 girls, for each age group, were found to have abnormal semen analysis. In other words, there are 5.8 million cases or 9,100 patients diagnosed annually with infertility in the United States. For a man, the number is 1,000; for a woman, 2,500. It is possible for more men than women to have an infertility problem, but it's also possible for more women than men to have an infertility problem. However, an infertility diagnosis is one of the most common diagnoses and will not go away unless it is solved. And it's one of the most stressful situations in family life." - Anonymous Online Contributor

Unverified Answer

Can infertility be cured?

"It is possible for infertility to be cured. However, the definition of being cured is elusive. It is important to understand the fact that treatment may not lead to a complete eradication of symptoms but that is certainly necessary for many couples. The treatment should always be tailored to individualities to maximize success. Thus it should be emphasized that infertility treatment has to be individualized." - Anonymous Online Contributor

Unverified Answer

How serious can infertility be?

"With the exception of the contraceptive qualities of Wild Yam and Pennyroyal, no herbal or medical treatment is considered as safe and efficacious as assisted reproduction techniques, yet is often vastly more affordable and available. It is clear in the series that there exists no consensus on proper use and dosage. It is also clear that fertility in general is not a serious problem in the United Kingdom as the vast majority of couples consider themselves to be infertile and in fact many people are fertile. To make a difference to fertility requires a more proactive position of the medical and political establishments and a willingness of both sexes to adopt a fertility-centered ideology." - Anonymous Online Contributor

Unverified Answer

Have there been any new discoveries for treating infertility?

"For instance, it was shown, that FSH has no significant effects on the endometrial transcriptome in both fresh-frozen and thawed thawed IVF cycles. Although its use has not changed much in infertility, there have been new treatments such as using the growth factors to stimulate endometrial hyperplasia to improve implantation rates in the ART-cycle. In the future, it is possible that these growth factors will be given by stimulating the endometrium to augment and improve endometrial receptivity which will hopefully improve the chances of the embryo implanting in the uterus." - Anonymous Online Contributor

Unverified Answer

What is the primary cause of infertility?

"The risk factors for the causes of infertile men are: Diabetes mellitus, a history of testicular and/or oocyte injury, and a family history of this disorder." - Anonymous Online Contributor

Unverified Answer

What are the latest developments in sufficient physical activity for therapeutic use?

"Sufficient physical activity can help to promote good pregnancy outcomes. However, there is still insufficient conclusive research concerning the effects of insufficient physical activity on pregnancy outcomes." - Anonymous Online Contributor

Unverified Answer

Does infertility run in families?

"The presence of infertility in male siblings should not be a reason for a man to seek a consultation with a physician. Although they may be in a hurry to have children, they don’t have the information needed to make a balanced decision about treatments before deciding to have a child with his partner. Male infertility is very common and has many causes. It is important for all couples considering having a child. Men should know how to deal effectively with any infertility problems found early so that they can avoid any unnecessary stress. It is important that both men and women know the information they need before deciding to have a child." - Anonymous Online Contributor

Unverified Answer

Have there been other clinical trials involving sufficient physical activity?

"Results from a recent paper is the first to examine clinical trials in which physical activity was prescribed in trials with couples exhibiting infertility. Results from a recent paper suggests that the combination of aerobic exercise and a program of progressive resistance exercise significantly increase the chance of pregnancy in women with fertility problems." - Anonymous Online Contributor

Unverified Answer
Please Note: These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
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