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Clinical Trials in Toronto, ON
View medical research that is recruiting in Toronto, ON. Filter by phase, distance, and inclusion criteria to find cutting edge treatments & access premium care.
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R-CHOP chemotherapy
Toronto, Canada
18+
All Sexes
Phase 2
Recruiting
Toronto, Canada
18+
All Sexes
This study is evaluating whether a drug called acalabrutinib can help treat mantle cell lymphoma.
CFI-402411
Toronto, Canada
18+
All Sexes
Phase 1 & 2
Recruiting
Locally Advanced
Toronto, Canada
18+
All Sexes
This study is evaluating whether an investigational drug may help treat patients with advanced solid tumors.
Topotecan Episcleral Plaque
Toronto, Canada
< 18
All Sexes
Phase 1
Recruiting
High Risk
Toronto, Canada
< 18
All Sexes
This study is evaluating whether a drug can be safely given to patients with retinoblastoma.
Venetoclax
Toronto, Canada
18+
All Sexes
Phase 3
Recruiting
Newly Diagnosed
Toronto, Canada
18+
All Sexes
Myelodysplastic Syndrome (MDS) is a group of disorders that gradually affect the ability of a person's bone marrow (semi-liquid tissue present in many bones like backbones) to produce normal blood cells. Some people with MDS have a risk of the disease progressing to acute myeloid leukemia …
PF-05221304
Edmonton, Canada
18+
All Sexes
Phase 2
Recruiting
Edmonton, Canada
18+
All Sexes
This study is evaluating whether two investigational drugs may help treat nonalcoholic steatohepatitis.
Nivolumab
Toronto, Canada
18+
All Sexes
Phase 3
Recruiting
Metastatic
Toronto, Canada
18+
All Sexes
This study is evaluating whether a combination of two immunotherapy drugs may help treat colorectal cancer.
PROMs Assessment
Toronto, Canada
18+
All Sexes
Recruiting
Toronto, Canada
18+
All Sexes
This study is evaluating whether PROMs can improve patient-provider communication and patient management.
CC-92480
Seattle, WA
18+
All Sexes
Phase 1 & 2
Recruiting
1 Prior Treatment
Seattle, WA
18+
All Sexes
This is an open-label, multi-center, international, Phase 1/2 study to assess the safety, PK and efficacy of CC-92480 monotherapy and in combination with dexamethasone in subjects with relapsed and refractory multiple myeloma (RRMM). RRMM patient previously treated with at least 3 prior r…
Pevonedistat
Mobile, AL
18+
All Sexes
Phase 3
1 Prior Treatment
Mobile, AL
18+
All Sexes
This study is evaluating whether a combination of two drugs may help treat myelodysplastic syndrome or chronic myelomonocytic leukemia.
Substance P
Toronto, Canada
< 65
All Sexes
Phase 1
Recruiting
Toronto, Canada
< 65
All Sexes
This study is evaluating whether a drug that stimulates the release of a neurotransmitter called substance P can improve blood sugar control in people with type 1 diabetes.
Prasinezumab
Toronto, Canada
18+
All Sexes
Phase 2
Recruiting
Stage I
Toronto, Canada
18+
All Sexes
This study is evaluating whether a drug may help people with Parkinson's disease.
Mitapivat
Durham, NC
18+
All Sexes
Phase 3
Recruiting
Durham, NC
18+
All Sexes
This study is evaluating whether a drug called mitapivat can improve anemia in people with thalassemia.
Odevixibat
Kansas City, MO
< 18
All Sexes
Phase 3
Recruiting
Kansas City, MO
< 18
All Sexes
This study is evaluating whether a drug may help children with biliary atresia.
Durvalumab
Washington, United States
18+
All Sexes
Phase 4
Washington, United States
18+
All Sexes
This study is evaluating whether a drug may help treat lung cancer.
RP1
Toronto, Canada
18+
All Sexes
Phase 2
Recruiting
Locally Advanced
Toronto, Canada
18+
All Sexes
This study is evaluating whether a drug may help treat patients with a certain type of skin cancer.
Solution-Focused Coaching in Pediatric Rehabilitation
Toronto, Canada
< 65
All Sexes
Toronto, Canada
< 65
All Sexes
This three year study explores the feasibility and acceptability of conducting a full randomized controlled trial (RCT) of a promising coaching intervention for improving and sustaining physical activity (PA) and healthy dietary habits in children with physical disabilities (CWPD). Thirty…
Palbociclib
Seattle, WA
18+
Female
Phase 1 & 2
Recruiting
Locally Advanced
Seattle, WA
18+
Female
Primary Objectives: Dose Escalation: To assess the incidence rate of dose-limiting toxicity (DLT) and to determine the maximum tolerated dose (MTD) as well as the recommended dose (RD) of amcenestrant administered as monotherapy and in combination with palbociclib To assess the incidence…
ALKS 4230 + pembrolizumab
Toronto, Canada
18+
All Sexes
Phase 1 & 2
Locally Advanced
Toronto, Canada
18+
All Sexes
This study is evaluating whether a drug may help treat alcohol use disorder.
WVE-003
Ottawa, Canada
18 - 65
All Sexes
Phase 1 & 2
Recruiting
Ottawa, Canada
18 - 65
All Sexes
This study is evaluating whether a drug called WVE-003 can slow the progression of Huntington's disease.
Troriluzole
DeSoto, TX
18+
All Sexes
Phase 3
Recruiting
DeSoto, TX
18+
All Sexes
This study is evaluating whether a drug may help reduce symptoms of obsessive compulsive disorder.
Olaparib
Toronto, Canada
18+
All Sexes
Phase 2
Recruiting
Locally Advanced
Toronto, Canada
18+
All Sexes
This study is evaluating whether a drug may help treat cancer.
TAK-935
Toronto, Canada
Any Age
All Sexes
Phase 2
Toronto, Canada
Any Age
All Sexes
This study is evaluating whether a drug may help reduce seizures in patients with epilepsy.
Ozanimod
Saint Louis, MO
18+
All Sexes
Phase 3
Recruiting
1 Prior Treatment
Saint Louis, MO
18+
All Sexes
This study is evaluating whether a drug may help treat Crohn's disease.
Medly
Toronto, Canada
18+
All Sexes
Recruiting
Toronto, Canada
18+
All Sexes
Heart failure is the most rapidly rising cardiovascular disease and has come to be recognized as a growing epidemic. Digital health interventions are the most recent iteration of an effort to promote individualized outpatient care through positive behaviour change theory. The UHN team has …
enfortumab vedotin (EV)
Jacksonville, FL
18+
All Sexes
Phase 1 & 2
Recruiting
Class III
Jacksonville, FL
18+
All Sexes
This study is evaluating whether an experimental drug may help treat bladder cancer.
iCanCope app and website
Toronto, Canada
< 65
All Sexes
Toronto, Canada
< 65
All Sexes
This study is evaluating whether a smartphone app and website can help AYA with chronic pain.
Postoperative intensity modulated radiation therapy
Toronto, Canada
18+
All Sexes
Phase 3
Recruiting
1 Prior Treatment
Toronto, Canada
18+
All Sexes
This study is evaluating whether a type of radiation therapy may help reduce complications after surgery for sarcoma.
Itepekimab SAR440340
Toronto, Canada
18+
All Sexes
Phase 3
Recruiting
Toronto, Canada
18+
All Sexes
Primary Objective: Primary population (former smokers cohort): Evaluate the efficacy of itepekimab compared with placebo on the annualized rate of acute moderate-or-severe COPD exacerbations in former smokers with moderate-to-severe COPD Secondary Objectives: Primary population (former…
tisotumab vedotin
Vancouver, Canada
18+
Female
Phase 3
Recruiting
Metastatic
Vancouver, Canada
18+
Female
This trial is being done to find out whether tisotumab vedotin works better than chemotherapy to treat cervical cancer. People in this study have cervical cancer that has spread to other parts of the body (metastatic) or has come back after being treated (recurrent). Participants in this …
Zilovertamab vedotin
Seattle, WA
18+
All Sexes
Phase 2
Recruiting
Metastatic
Seattle, WA
18+
All Sexes
This study is evaluating whether an antibody-drug conjugate (ADC) which targets a receptor on cancer cells may help treat cancer.
TAK-676
Toronto, Canada
18+
All Sexes
Phase 1
Recruiting
Grade I
Toronto, Canada
18+
All Sexes
The main aim of this study is to check if people with advanced solid tumors have side effects from TAK-676, and to check how much TAK-676 they can receive without getting significant side effects from it when given alone and in combination with pembrolizumab. The study will be conducted in…
Olaparib
Toronto, Canada
18+
All Sexes
Phase 2 & 3
Grade I
Toronto, Canada
18+
All Sexes
The purpose of this study is to compare the efficacy of olaparib (MK-7339) plus pembrolizumab (MK-3475) with chemotherapy plus pembrolizumab after induction with first-line chemotherapy plus pembrolizumab in triple negative breast cancer (TNBC). The primary hypotheses are: Olaparib plus p…
Lutathera
Toronto, Canada
Any Age
All Sexes
Phase 3
Recruiting
Grade II
Toronto, Canada
Any Age
All Sexes
This study is evaluating whether a combination of two drugs may help treat neuroendocrine tumors.
Atorvastatin
Toronto, Canada
18+
All Sexes
Phase 2
Toronto, Canada
18+
All Sexes
This study is evaluating whether a statin can prevent heart failure in people with cancer.
Facilitate tDCS + CR
Toronto, Canada
18+
All Sexes
High Risk
Toronto, Canada
18+
All Sexes
This study is evaluating whether a home-based intervention can improve cognition in people at risk for Alzheimer's disease.
Macitentan
Toronto, Canada
< 18
All Sexes
Phase 3
Recruiting
Class I
Toronto, Canada
< 18
All Sexes
This study is evaluating whether a drug called macitentan may help children with pulmonary arterial hypertension.
Ziv-Aflibercept
Toronto, Canada
18+
All Sexes
Phase 1
Recruiting
Locally Advanced
Toronto, Canada
18+
All Sexes
This study is evaluating whether a combination of two drugs may help treat patients with advanced solid tumors.
RO7293583
Toronto, Canada
18+
All Sexes
Phase 1
Grade II
Toronto, Canada
18+
All Sexes
This study is evaluating whether a drug may help treat melanoma.
FT218
Malvern, PA
Any Age
All Sexes
Phase 3
Recruiting
Malvern, PA
Any Age
All Sexes
This study is evaluating whether a new formulation of sodium oxybate may help treat narcolepsy.
MitraClip™ device implantation
Wichita, KS
18+
All Sexes
Recruiting
Class II
Wichita, KS
18+
All Sexes
This study is evaluating whether a new device may help treat mitral regurgitation.
SUVN-G3031
Canton, OH
18+
All Sexes
Phase 2
Recruiting
Canton, OH
18+
All Sexes
This study is evaluating whether a drug may help treat narcolepsy.
Respiratory Mechanics
New York, NY
18+
All Sexes
Recruiting
New York, NY
18+
All Sexes
This study is evaluating whether a ventilator protocol can reduce mortality in patients with acute respiratory distress syndrome.
Pomalidomide
Toronto, Canada
18+
All Sexes
Phase 2
Recruiting
Toronto, Canada
18+
All Sexes
This study is evaluating whether desensitization is safe and useful for patients with multiple myeloma or amyloidosis.
Osimertinib
Santa Monica, CA
18+
All Sexes
Phase 2
Recruiting
Locally Advanced
Santa Monica, CA
18+
All Sexes
This study is evaluating whether a combination of drugs may help treat lung cancer.
Cisplatin
Aurora, CO
< 65
All Sexes
Phase 2 & 3
Recruiting
High Risk
Aurora, CO
< 65
All Sexes
This study is evaluating whether cisplatin and combination chemotherapy may help treat children and young adults with hepatoblastoma or hepatocellular carcinoma.
Multiple arterial grafting
Toronto, Canada
18+
All Sexes
Recruiting
Toronto, Canada
18+
All Sexes
The primary hypothesis of ROMA is that in patients undergoing primary isolated non-emergent coronary artery bypass surgery (CABG), the use of two or more arterial grafts compared to a single arterial graft is associated with a reduction in the composite outcome of death from any cause, any…
Effectiveness of early switch to oral antibiotics
Toronto, Canada
Any Age
All Sexes
Phase 4
Recruiting
Toronto, Canada
Any Age
All Sexes
The Staphylococcus aureus Network Adaptive Platform (SNAP) trial is an International Multi-Centered Randomised Adaptive Platform Clinical Trial to evaluate a range of interventions to reduce mortality for patients with Staphylococcus Aureus bacteraemia (SAB).
Salvage radiotherapy
Toronto, Canada
18+
Male
Phase 2
Recruiting
1 Prior Treatment
Toronto, Canada
18+
Male
The investigators will randomize patients presenting with early BCR with a negative baseline PSMA PET/CT, to upfront SRT or surveillance. Early BCR is defined as a PSA relapse of >0.1 to <0.3 ng/mL. Patients in the surveillance arm will be monitored with PSA every 3 months. A repeat PSMA P…
Peer health coaching
Toronto, Canada
18+
All Sexes
Recruiting
Toronto, Canada
18+
All Sexes
The Building on Existing Tools To improvE cancer and chronic disease pRevention and screening in primary care (BETTER) Program allows patients in primary care to have a dedicated visit with a prevention practitioner to discuss chronic disease prevention and cancer screening. A prevention p…
Lenvatinib
Toronto, Canada
18+
All Sexes
Phase 2
Locally Advanced
Toronto, Canada
18+
All Sexes
This study is evaluating whether a combination of two drugs may help treat advanced kidney cancer.
Idasanutlin
Billings, MT
Any Age
All Sexes
Phase 2
Recruiting
Locally Advanced
Billings, MT
Any Age
All Sexes
This study is evaluating whether a drug regimen tailored to a specific genetic profile may help treat cancer.
Nemolizumab
Cortland, NY
Any Age
All Sexes
Phase 3
Recruiting
Cortland, NY
Any Age
All Sexes
This study is evaluating whether a drug may help treat atopic dermatitis.
CTL019
Indianapolis, IN
< 65
All Sexes
Phase 2
Recruiting
Grade I
Indianapolis, IN
< 65
All Sexes
This study is evaluating whether a treatment for leukemia may help patients live longer.
AZR-MD-001 Low Dose
Toronto, Canada
18+
All Sexes
Phase 2
Recruiting
Toronto, Canada
18+
All Sexes
This study is evaluating whether a topical ointment can improve symptoms of MGD and DED.
PRN1008
Montréal, Canada
18+
All Sexes
Phase 1 & 2
Recruiting
1 Prior Treatment
Montréal, Canada
18+
All Sexes
This study is evaluating whether a drug may help treat a rare blood disorder.
Stereotactic Body Radiation Therapy (SABR)
Toronto, Canada
18+
Male
Recruiting
Metastatic
Toronto, Canada
18+
Male
This study is evaluating whether stereotactic ablative body radiotherapy can be used to treat oligoprogressive metastases in men with prostate cancer.
Belantamab mafodotin
Pembroke Pines, FL
18+
All Sexes
Phase 3
Recruiting
Grade I
Pembroke Pines, FL
18+
All Sexes
This study is evaluating whether a combination of drugs may help treat multiple myeloma.
V938
Toronto, Canada
18+
All Sexes
Phase 1
Recruiting
Locally Advanced
Toronto, Canada
18+
All Sexes
This study is evaluating whether a combination of two drugs may help treat cancer.
Futibatinib plus Fulvestrant
Calgary, Canada
18+
All Sexes
Phase 2
Recruiting
Locally Advanced
Calgary, Canada
18+
All Sexes
This study is evaluating whether a drug may help treat breast cancer.
AeroFact
Jacksonville, FL
< 18
All Sexes
Phase 2
Recruiting
Jacksonville, FL
< 18
All Sexes
This study is evaluating whether a drug may help improve breathing in premature infants.
Vibegron
Houston, TX
18+
Male
Phase 3
Recruiting
Houston, TX
18+
Male
This study is evaluating whether a drug may help men with overactive bladder.
SLC-0111
Toronto, Canada
18+
All Sexes
Phase 1 & 2
Recruiting
Locally Advanced
Toronto, Canada
18+
All Sexes
This study is evaluating whether a drug called SLC-0111 can be safely given to people with pancreatic cancer.
Talimogene Laherparepvec
Toronto, Canada
18+
All Sexes
Phase 2
Recruiting
Grade II
Toronto, Canada
18+
All Sexes
This study is evaluating whether a combination of a biological therapy and radiation therapy may help treat patients with soft tissue sarcoma.
Dialectical behavioral therapy
Toronto, Canada
< 65
All Sexes
Recruiting
Toronto, Canada
< 65
All Sexes
Dialectical behavior therapy (DBT) will be conducted over 1 year in youth with bipolar disorder (BD). DBT will be divided into two modalities: 1) DBT skills training; and 2) DBT individual therapy sessions. Skills training sessions will incorporate the 5 standard adolescent DBT modules: mi…
Dupilumab
Montreal, Canada
18+
All Sexes
Phase 4
Recruiting
Montreal, Canada
18+
All Sexes
This is an interventional, randomized, parallel group, treatment, Phase 3b/4, double blind, 2-arm study to assess the effect of dupilumab compared to standard of care therapy on preventing or slowing the rate of lung function decline in adult patients with uncontrolled moderate to severe a…
PF-06946860
Los Angeles, CA
18+
All Sexes
Phase 1
Locally Advanced
Los Angeles, CA
18+
All Sexes
This study is evaluating whether a drug may help increase appetite in patients with advanced cancer.
Physical Activity (PA) Intervention
Toronto, Canada
< 65
All Sexes
Recruiting
Toronto, Canada
< 65
All Sexes
This study is evaluating whether a smartphone app can help increase physical activity in youth with multiple sclerosis.
lenvatinib
Toronto, Canada
18+
All Sexes
Phase 3
Metastatic
Toronto, Canada
18+
All Sexes
The purpose of this study is to assess the safety and efficacy of lenvatinib (MK-7902/E7080) in combination with pembrolizumab (MK-3475) in participants with metastatic colorectal cancer. The study will also compare lenvatinib plus pembrolizumab with the standard of care treatment of regor…
Axatilimab
Birmingham, AL
Any Age
All Sexes
Phase 2
Recruiting
1 Prior Treatment
Birmingham, AL
Any Age
All Sexes
This study is evaluating whether a drug may help reduce the symptoms of chronic graft versus host disease.
LOXO-305
Toronto, Canada
18+
All Sexes
Phase 3
Recruiting
Toronto, Canada
18+
All Sexes
This study is evaluating whether a drug called LOXO-305 may help treat chronic lymphocytic leukemia.
RO7283420
Toronto, Canada
18+
All Sexes
Phase 1
Recruiting
1 Prior Treatment
Toronto, Canada
18+
All Sexes
This study is evaluating whether a drug may help treat acute myeloid leukemia.
PEG IFN-alfa-2a
New York, NY
18+
All Sexes
Phase 3
Recruiting
New York, NY
18+
All Sexes
This study is evaluating whether two different treatments for hepatitis C virus (HCV) are effective.
Inavolisib
Toronto, Canada
18+
All Sexes
Phase 1
Recruiting
Locally Advanced
Toronto, Canada
18+
All Sexes
This study is evaluating whether a drug may help treat breast cancer.
TIME™ at Home
Halifax, Canada
18+
All Sexes
Recruiting
Class VI
Halifax, Canada
18+
All Sexes
Balance and mobility limitations can lead to increased difficulty with everyday function and increased dependence on caregivers. Adults with balance and mobility limitations need access to safe and beneficial exercise programs to maintain or improve their health. Task-oriented exercise pro…
GSK3810109A
Toronto, Canada
18+
All Sexes
Phase 2
Recruiting
Newly Diagnosed
Toronto, Canada
18+
All Sexes
This study is evaluating whether a new drug can reduce the amount of HIV in the body.
Semagludtide
Houston, TX
18+
All Sexes
Phase 3
Recruiting
Houston, TX
18+
All Sexes
This study is done to find out whether the medicine, semaglutide, has a positive effect on early Alzheimer's disease. Participants will either get semaglutide or placebo (a "dummy" medicine which does not contain any study medicine) - which treatment participants get is decided by an equa…
Sasanlimab
Los Angeles, CA
18+
All Sexes
Phase 1 & 2
Recruiting
Locally Advanced
Los Angeles, CA
18+
All Sexes
Phase 1b/Phase 2 Umbrella Study; open-label, multi-center, parallel group study. Sasanlimab (a PD-1 antagonist monoclonal antibody) will be combined with a different targeted therapy in each sub-study. Phase1b of each sub-study will evaluate the safety of the combination and select the do…
CLR 131
Palo Alto, CA
< 65
All Sexes
Phase 1
Recruiting
Metastatic
Palo Alto, CA
< 65
All Sexes
This study is evaluating whether a drug called CLR 131 may help treat cancer.
Crizanlizumab
Charleston, SC
< 18
All Sexes
Phase 2
Recruiting
Low Risk
Charleston, SC
< 18
All Sexes
This study is evaluating whether a drug may help children with sickle cell disease.
TNO155
Toronto, Canada
18+
All Sexes
Phase 1
Recruiting
Locally Advanced
Toronto, Canada
18+
All Sexes
This study is evaluating whether a drug which blocks a protein may help treat cancer.
Gantenerumab
Toronto, Canada
18+
All Sexes
Phase 2 & 3
Recruiting
Toronto, Canada
18+
All Sexes
This study is evaluating whether a drug may help slow the progression of Alzheimer's disease.
Semaglutide
Saint Paul, MN
18+