Clinical Trials in Toronto, ON

View medical research that is recruiting in Toronto, ON. Filter by phase, distance, and inclusion criteria to find cutting edge treatments & access premium care.

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This study is evaluating whether a drug called acalabrutinib can help treat mantle cell lymphoma.

This study is evaluating whether an investigational drug may help treat patients with advanced solid tumors.

Topotecan Episcleral Plaque

This study is evaluating whether a drug can be safely given to patients with retinoblastoma.

Myelodysplastic Syndrome (MDS) is a group of disorders that gradually affect the ability of a person's bone marrow (semi-liquid tissue present in many bones like backbones) to produce normal blood cells. Some people with MDS have a risk of the disease progressing to acute myeloid leukemia …

This study is evaluating whether two investigational drugs may help treat nonalcoholic steatohepatitis.

This study is evaluating whether a combination of two immunotherapy drugs may help treat colorectal cancer.

This study is evaluating whether PROMs can improve patient-provider communication and patient management.

This is an open-label, multi-center, international, Phase 1/2 study to assess the safety, PK and efficacy of CC-92480 monotherapy and in combination with dexamethasone in subjects with relapsed and refractory multiple myeloma (RRMM). RRMM patient previously treated with at least 3 prior r…

This study is evaluating whether a combination of two drugs may help treat myelodysplastic syndrome or chronic myelomonocytic leukemia.

This study is evaluating whether a drug that stimulates the release of a neurotransmitter called substance P can improve blood sugar control in people with type 1 diabetes.

This study is evaluating whether a drug may help people with Parkinson's disease.

This study is evaluating whether a drug called mitapivat can improve anemia in people with thalassemia.

This study is evaluating whether a drug may help children with biliary atresia.

Durvalumab

Washington, United States

18+

All Sexes

Phase 4

Washington, United States

18+

All Sexes

This study is evaluating whether a drug may help treat lung cancer.

This study is evaluating whether a drug may help treat patients with a certain type of skin cancer.

Solution-Focused Coaching in Pediatric Rehabilitation

This three year study explores the feasibility and acceptability of conducting a full randomized controlled trial (RCT) of a promising coaching intervention for improving and sustaining physical activity (PA) and healthy dietary habits in children with physical disabilities (CWPD). Thirty…

Primary Objectives: Dose Escalation: To assess the incidence rate of dose-limiting toxicity (DLT) and to determine the maximum tolerated dose (MTD) as well as the recommended dose (RD) of amcenestrant administered as monotherapy and in combination with palbociclib To assess the incidence…

ALKS 4230 + pembrolizumab

This study is evaluating whether a drug may help treat alcohol use disorder.

This study is evaluating whether a drug called WVE-003 can slow the progression of Huntington's disease.

This study is evaluating whether a drug may help reduce symptoms of obsessive compulsive disorder.

This study is evaluating whether a drug may help treat cancer.

This study is evaluating whether a drug may help reduce seizures in patients with epilepsy.

This study is evaluating whether a drug may help treat Crohn's disease.

Heart failure is the most rapidly rising cardiovascular disease and has come to be recognized as a growing epidemic. Digital health interventions are the most recent iteration of an effort to promote individualized outpatient care through positive behaviour change theory. The UHN team has …

enfortumab vedotin (EV)

This study is evaluating whether an experimental drug may help treat bladder cancer.

iCanCope app and website

This study is evaluating whether a smartphone app and website can help AYA with chronic pain.

Postoperative intensity modulated radiation therapy

This study is evaluating whether a type of radiation therapy may help reduce complications after surgery for sarcoma.

Primary Objective: Primary population (former smokers cohort): Evaluate the efficacy of itepekimab compared with placebo on the annualized rate of acute moderate-or-severe COPD exacerbations in former smokers with moderate-to-severe COPD Secondary Objectives: Primary population (former…

This trial is being done to find out whether tisotumab vedotin works better than chemotherapy to treat cervical cancer. People in this study have cervical cancer that has spread to other parts of the body (metastatic) or has come back after being treated (recurrent). Participants in this …

This study is evaluating whether an antibody-drug conjugate (ADC) which targets a receptor on cancer cells may help treat cancer.

The main aim of this study is to check if people with advanced solid tumors have side effects from TAK-676, and to check how much TAK-676 they can receive without getting significant side effects from it when given alone and in combination with pembrolizumab. The study will be conducted in…

The purpose of this study is to compare the efficacy of olaparib (MK-7339) plus pembrolizumab (MK-3475) with chemotherapy plus pembrolizumab after induction with first-line chemotherapy plus pembrolizumab in triple negative breast cancer (TNBC). The primary hypotheses are: Olaparib plus p…

This study is evaluating whether a combination of two drugs may help treat neuroendocrine tumors.

This study is evaluating whether a statin can prevent heart failure in people with cancer.

This study is evaluating whether a home-based intervention can improve cognition in people at risk for Alzheimer's disease.

This study is evaluating whether a drug called macitentan may help children with pulmonary arterial hypertension.

This study is evaluating whether a combination of two drugs may help treat patients with advanced solid tumors.

This study is evaluating whether a drug may help treat melanoma.

This study is evaluating whether a new formulation of sodium oxybate may help treat narcolepsy.

MitraClip™ device implantation

This study is evaluating whether a new device may help treat mitral regurgitation.

This study is evaluating whether a drug may help treat narcolepsy.

Respiratory Mechanics

This study is evaluating whether a ventilator protocol can reduce mortality in patients with acute respiratory distress syndrome.

This study is evaluating whether desensitization is safe and useful for patients with multiple myeloma or amyloidosis.

This study is evaluating whether a combination of drugs may help treat lung cancer.

This study is evaluating whether cisplatin and combination chemotherapy may help treat children and young adults with hepatoblastoma or hepatocellular carcinoma.

Multiple arterial grafting

The primary hypothesis of ROMA is that in patients undergoing primary isolated non-emergent coronary artery bypass surgery (CABG), the use of two or more arterial grafts compared to a single arterial graft is associated with a reduction in the composite outcome of death from any cause, any…

Effectiveness of early switch to oral antibiotics

The Staphylococcus aureus Network Adaptive Platform (SNAP) trial is an International Multi-Centered Randomised Adaptive Platform Clinical Trial to evaluate a range of interventions to reduce mortality for patients with Staphylococcus Aureus bacteraemia (SAB).

The investigators will randomize patients presenting with early BCR with a negative baseline PSMA PET/CT, to upfront SRT or surveillance. Early BCR is defined as a PSA relapse of >0.1 to <0.3 ng/mL. Patients in the surveillance arm will be monitored with PSA every 3 months. A repeat PSMA P…

The Building on Existing Tools To improvE cancer and chronic disease pRevention and screening in primary care (BETTER) Program allows patients in primary care to have a dedicated visit with a prevention practitioner to discuss chronic disease prevention and cancer screening. A prevention p…

This study is evaluating whether a combination of two drugs may help treat advanced kidney cancer.

This study is evaluating whether a drug regimen tailored to a specific genetic profile may help treat cancer.

This study is evaluating whether a drug may help treat atopic dermatitis.

This study is evaluating whether a treatment for leukemia may help patients live longer.

This study is evaluating whether a topical ointment can improve symptoms of MGD and DED.

This study is evaluating whether a drug may help treat a rare blood disorder.

Stereotactic Body Radiation Therapy (SABR)

This study is evaluating whether stereotactic ablative body radiotherapy can be used to treat oligoprogressive metastases in men with prostate cancer.

This study is evaluating whether a combination of drugs may help treat multiple myeloma.

This study is evaluating whether a combination of two drugs may help treat cancer.

Futibatinib plus Fulvestrant

This study is evaluating whether a drug may help treat breast cancer.

This study is evaluating whether a drug may help improve breathing in premature infants.

This study is evaluating whether a drug may help men with overactive bladder.

This study is evaluating whether a drug called SLC-0111 can be safely given to people with pancreatic cancer.

Talimogene Laherparepvec

This study is evaluating whether a combination of a biological therapy and radiation therapy may help treat patients with soft tissue sarcoma.

Dialectical behavioral therapy

Dialectical behavior therapy (DBT) will be conducted over 1 year in youth with bipolar disorder (BD). DBT will be divided into two modalities: 1) DBT skills training; and 2) DBT individual therapy sessions. Skills training sessions will incorporate the 5 standard adolescent DBT modules: mi…

This is an interventional, randomized, parallel group, treatment, Phase 3b/4, double blind, 2-arm study to assess the effect of dupilumab compared to standard of care therapy on preventing or slowing the rate of lung function decline in adult patients with uncontrolled moderate to severe a…

This study is evaluating whether a drug may help increase appetite in patients with advanced cancer.

Physical Activity (PA) Intervention

This study is evaluating whether a smartphone app can help increase physical activity in youth with multiple sclerosis.

The purpose of this study is to assess the safety and efficacy of lenvatinib (MK-7902/E7080) in combination with pembrolizumab (MK-3475) in participants with metastatic colorectal cancer. The study will also compare lenvatinib plus pembrolizumab with the standard of care treatment of regor…

This study is evaluating whether a drug may help reduce the symptoms of chronic graft versus host disease.

This study is evaluating whether a drug called LOXO-305 may help treat chronic lymphocytic leukemia.

This study is evaluating whether a drug may help treat acute myeloid leukemia.

This study is evaluating whether two different treatments for hepatitis C virus (HCV) are effective.

This study is evaluating whether a drug may help treat breast cancer.

Balance and mobility limitations can lead to increased difficulty with everyday function and increased dependence on caregivers. Adults with balance and mobility limitations need access to safe and beneficial exercise programs to maintain or improve their health. Task-oriented exercise pro…

This study is evaluating whether a new drug can reduce the amount of HIV in the body.

This study is done to find out whether the medicine, semaglutide, has a positive effect on early Alzheimer's disease. Participants will either get semaglutide or placebo (a "dummy" medicine which does not contain any study medicine) - which treatment participants get is decided by an equa…

Phase 1b/Phase 2 Umbrella Study; open-label, multi-center, parallel group study. Sasanlimab (a PD-1 antagonist monoclonal antibody) will be combined with a different targeted therapy in each sub-study. Phase1b of each sub-study will evaluate the safety of the combination and select the do…

This study is evaluating whether a drug called CLR 131 may help treat cancer.

This study is evaluating whether a drug may help children with sickle cell disease.

This study is evaluating whether a drug which blocks a protein may help treat cancer.

This study is evaluating whether a drug may help slow the progression of Alzheimer's disease.

Semaglutide

Saint Paul, MN

18+