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Submaximal Exercise Protocol for Down Syndrome

N/A

Recruiting

Led By Victor DY Beck, MS

Research Sponsored by University of Nevada, Las Vegas

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Diagnosis with Down syndrome trisomy 21 (Down syndrome group only)

Be between 18 and 65 years old

Timeline

Screening 3 weeks

Treatment Varies

Follow Up through study completion, on average 4 hours

Awards & highlights

Study Summary

This trial aims to explore why adults with Down Syndrome are often intolerant to exercise, to help improve their exercise experience.

Who is the study for?

This trial is for low-active adults with Down syndrome, meaning they engage in less than 30 minutes of moderate exercise daily. They must have normal or stable thyroid function. It's not open to those with severe obesity, uncontrolled high blood pressure, heart disease, diabetes, current smokers, or pregnant individuals.Check my eligibility

What is being tested?

The study tests how quickly adults with Down syndrome adjust their oxygen uptake during moderate treadmill exercise compared to those without the condition. It measures lung oxygen uptake, cardiac output and muscle oxygen use to improve understanding of their exercise capacity.See study design

What are the potential side effects?

Since this trial involves a submaximal exercise protocol on a treadmill rather than medication or invasive procedures, side effects are minimal but may include typical exercise-related responses such as shortness of breath or muscle fatigue.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

Select...

I have been diagnosed with Down syndrome.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ through study completion, on average 4 hours

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~through study completion, on average 4 hours

This trial's timeline: 3 weeks for screening, Varies for treatment, and through study completion, on average 4 hours for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

Oxygen uptake kinetics

Secondary outcome measures

Absolute peak oxygen uptake

Cardiac output kinetics

Heart rate

+10 more

Trial Design

2Treatment groups

Experimental Treatment

Group I: control without Down syndromeExperimental Treatment1 Intervention

This group of age- and sex-matched participants without Down syndrome will undergo the same testing as participants with Down syndrome

Group II: Down syndromeExperimental Treatment1 Intervention

Participants will complete a submaximal walking protocol on a motorized treadmill, which consists of 4 times 6 minutes of walking at a moderate intensity speed and incline while their breathing, cardiac output, and muscle oxygen use is measured, with 10 minutes rest in between each bout.

0 / 1Eligibility criteria met

Find a Location

Who is running the clinical trial?

University of Nevada, Las VegasLead Sponsor

66 Previous Clinical Trials

13,769 Total Patients Enrolled

2 Trials studying Down Syndrome

80 Patients Enrolled for Down Syndrome

Victor DY Beck, MSPrincipal InvestigatorUniversity of Nevada, Las Vegas

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What qualifications are necessary for eligibility in this research endeavor?

"Candidates for this trial should have Down syndrome and must be between 18 to 35 years of age. This research endeavour seeks approximately 30 individuals in total."

Answered by AI

Is this experimental research available to geriatric individuals?

"This research trial is open to individuals aged 18 to 35. Meanwhile, there are 370 trials specifically for minors and 995 studies targeting seniors."

Answered by AI

How many individuals are being accepted to participate in this experiment?

"Affirmative. Clinicaltrials.gov provides evidence that recruitment for this clinical trial is ongoing, having initially been advertised on September 1st 2023 and recently updated on the 12th of the same month. This research intends to recruit 30 persons from a single site."

Answered by AI

Is this research endeavor currently enrolling participants?

"Affirmative. According to the information hosted on clinicaltrials.gov, this medical trial is actively recruiting participants and was first published on September 1st 2025 with a most recent update occuring 12 days ago. Presently, 30 patients are needed from one single site for enrollment purposes."

Answered by AI

Recent research and studies

clinicaltrials.govStudy

Oxygen Uptake Kinetics During Submaximal Exercise in Adults With Down Syndrome

Victor Beck 2023. "Oxygen Uptake Kinetics During Submaximal Exercise in Adults With Down Syndrome". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT05995223.

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