Lynch Syndrome Clinical Trials
Here are the 6 most popular medical studies for lynch syndrome
Anti-metabolites
Combination Chemotherapy for Metastatic Colorectal Cancer
This trial is studying a treatment for colorectal cancer that has spread to the liver. The treatment is a combination of chemotherapy drugs and two other drugs, given directly into the arteries around the tumor.
Tyrosine Kinase Inhibitor
Entrectinib for Solid Tumors with Gene Rearrangements
This trial is testing a new drug, entrectinib, for patients with different types of solid tumors that have a gene fusion. Patients will be assigned to different groups depending on their tumor type and gene fusion.
PD-L1 Inhibitor
Durvalumab + Olaparib + Cediranib for Advanced Solid Tumors and Breast Cancer
This trial is testing the combination of Durvalumab, Olaparib, and Cediranib in adults with advanced or recurrent ovarian cancer to see how well they tolerate it and if it is effective in treating the cancer.
Popular filter options for lynch syndrome trials
Colorectal Cancer Clinical Trials
View 87 Colorectal Cancer medical studies.
Alkylating agents
Combination Chemotherapy for Colorectal Cancer
This trial is testing a new cancer treatment for people who have had part of their liver removed. It's a combination of two drugs given through an IV, plus a third drug given through a pump that goes directly to the liver. The goal is to find the best dose of each drug to give, based on how well the patient tolerates the treatment.
Wnt Inhibitor
LGK974 for Malignancies Dependent on Wnt Ligands
This trial is testing a new drug called LGK974 to see if it is safe and effective in treating adults with cancer that has progressed despite standard therapy or for which no effective standard therapy exists.
Colon Cancer Clinical Trials
View 86 Colon Cancer medical studies.
Alkylating agents
Combination Chemotherapy for Colorectal Cancer
This trial is testing a new cancer treatment for people who have had part of their liver removed. It's a combination of two drugs given through an IV, plus a third drug given through a pump that goes directly to the liver. The goal is to find the best dose of each drug to give, based on how well the patient tolerates the treatment.
Wnt Inhibitor
LGK974 for Malignancies Dependent on Wnt Ligands
This trial is testing a new drug called LGK974 to see if it is safe and effective in treating adults with cancer that has progressed despite standard therapy or for which no effective standard therapy exists.
BRAF Positive Clinical Trials
View 10 BRAF positive medical studies.
Wnt Inhibitor
LGK974 for Malignancies Dependent on Wnt Ligands
This trial is testing a new drug called LGK974 to see if it is safe and effective in treating adults with cancer that has progressed despite standard therapy or for which no effective standard therapy exists.
Kinase Inhibitor
Vemurafenib + Cetuximab + Irinotecan Hydrochloride for Solid Tumors
This trial is testing the side effects and best dose of vemurafenib when given with cetuximab and irinotecan hydrochloride to treat patients with solid tumors. Vemurafenib and irinotecan hydrochloride may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Cetuximab may help the body's immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread.
Tyrosine Kinase Inhibitor
Pralsetinib for Thyroid Cancer and Non-Small Cell Lung Cancer
This trial is testing a new drug, pralsetinib, to see if it is safe and effective in treating medullary thyroid cancer, RET-altered non-small cell lung cancer, and other RET-altered solid tumors.
Alkylating agents
Chemotherapy with HAIP for Colorectal Cancer with Liver Metastases
This trial is for people with colorectal cancer that has spread to their liver. It is testing if a pump that gives chemotherapy drugs directly to the liver for 2 weeks at a time is effective.
PD-1 Positive Clinical Trials
View 10 PD-1 positive medical studies.
Wnt Inhibitor
LGK974 for Malignancies Dependent on Wnt Ligands
This trial is testing a new drug called LGK974 to see if it is safe and effective in treating adults with cancer that has progressed despite standard therapy or for which no effective standard therapy exists.
Checkpoint Inhibitor
Nivolumab Combination Therapy for Colorectal Cancer
“ At time of my diaognosis ,my test came back good,but my doctors would not consider any alternative options.They only wanted to do surgery and leave me with a bag.”
Monoclonal Antibodies
Utomilumab + Cetuximab + Irinotecan Hydrochloride for Colorectal Cancer
This trial is studying the best dose and side effects of irinotecan hydrochloride given with utomilumab and cetuximab to treat patients with metastatic colorectal cancer.
PD-1/PD-L1 Checkpoint Inhibitor
Nivolumab +4 More for Kidney Cancer
This trial is studying a combination of immunotherapies to see if they help patients with cancer that has progressed after treatment with a PD-1/PD-L1 checkpoint inhibitor. The study has five cohorts of patients. All patients will receive N-803 once every 3 weeks. Patients in Cohorts 1-4 will receive the combination treatment of PD-1/PD-L1 checkpoint inhibitor plus N-803 for up to 17 cycles. Some patients who experience disease progression while on study in Cohorts 1-4 may roll over into Cohort 5 and receive combination therapy with a PD-1/PD-L1 checkpoint inhibitor, N
Phase 3 Lynch Syndrome Clinical Trials
View 91 phase 3 lynch syndrome medical studies.
Chemotherapy
Combination Therapy for Colorectal Cancer
“ Fortunately, so far, I have not needed treatement but am being moniored by my urologist. Obviously, I wish to take advantage of any process that may help avoid problems in the future.”
Lynch Syndrome Clinical Trials With No Placebo
View 91 lynch syndrome medical studies that do not have a placebo group.
Alkylating agents
Combination Chemotherapy for Colorectal Cancer
This trial is testing a new cancer treatment for people who have had part of their liver removed. It's a combination of two drugs given through an IV, plus a third drug given through a pump that goes directly to the liver. The goal is to find the best dose of each drug to give, based on how well the patient tolerates the treatment.
Wnt Inhibitor
LGK974 for Malignancies Dependent on Wnt Ligands
This trial is testing a new drug called LGK974 to see if it is safe and effective in treating adults with cancer that has progressed despite standard therapy or for which no effective standard therapy exists.
Chemotherapy
Ursodiol + Combination Chemotherapy + Bevacizumab for Colorectal Cancer
This trial is studying the side effects and best dose of the drug ursodiol when given together with combination chemotherapy (leucovorin calcium, fluorouracil, and oxaliplatin) and bevacizumab in treating patients with stage IV colorectal cancer.
View More Lynch Syndrome Trials
See another 65 many medical studies focused on lynch syndrome.
Frequently Asked Questions
Introduction to lynch syndrome
What are the top hospitals conducting lynch syndrome research?
Lynch syndrome, a hereditary condition associated with an increased risk of certain cancers, is receiving focused attention at several top hospitals across the United States. In Atlanta, Emory University Hospital and its Winship Cancer Institute lead the way with an impressive 13 ongoing clinical trials dedicated to understanding and treating this syndrome. Despite having only one previously recorded trial in their history dating back to 2005, their commitment to research remains unwavering. Meanwhile, M D Anderson Cancer Center in Houston boasts both a strong presence and extensive experience in studying lynch syndrome. With 12 active trials currently underway and eight previous trials conducted since their inaugural study in 2005.
In New York City's renowned Memorial Sloan Kettering Cancer Center, researchers are engaged in pushing the boundaries of knowledge surrounding lynch syndrome through their participation in eleven ongoing clinical trials as well as four completed studies that date all the way back to 2004. The Mayo Clinic's Arizonahip Cancer Institute lead the way with an impressive 13 ongoing clinical trials dedicated to understanding and treating this syndrome. Despite having only one previously recorded trial in their history dating back to 2005, their commitment to research remains unwavering. Meanwhile, M D Anderson Cancer Center in Houston boasts both a strong presence and extensive experience in studying lynch syndrome. With 12 active trials currently underway and eight previous trials conducted since their inaugural study in 2005.
In New York City's renowned Memorial Sloan Kettering Cancer Center, researchers are engaged in pushing the boundaries of knowledge surrounding lynch syndrome through their participation in eleven ongoing clinical trials as well as four completed studies that date all the way back to 2004. The Mayo Clinic's Arizona branch located in Scottsdale contributes significantly too—it has eight active lynch syndrome trials running alongside three earlier endeavors initiated starting from 2005.
Lastly, Duke University Medical Center located conveniently at Durham joins these prestigious institutions by actively participating with eight current lynch syndrome clinical tests while contributing towards two prior investigations which they embarked on since recording first such case trial also dated back around similar time period of early- mid-2000s .
These leading hospitals exemplify the dedication and momentum driving research on Lynch Syndrome nationwide. By continually expanding our understanding of this condition through cutting-edge clinical trials, scientists strive for improved prevention strategies and better treatment options for individuals impacted by Lynch Syndrome—a true testament to medical progress fueled by tireless efforts within diverse locations throughout the United States
Which are the best cities for lynch syndrome clinical trials?
Los Angeles, California; Boston, Massachusetts, California; Boston, Massachusetts; and Atlanta, Georgia are the top cities for lynch syndrome clinical trials. Los Angeles leads with 43 active trials investigating treatments like Nivolumab and Eflornithine plus sulindac. In Boston, there are 37 ongoing studies focusing on interventions such as Radiation Therapy and pembrolizumab. Atlanta follows closely behind with 30 active trials exploring options like Radiation Therapy and Anti-SEMA4D Monoclonal Antibody VX15/2503. These cities offer individuals affected by lynch syndrome access to cutting-edge clinical trials that contribute to advancements in treatment options for this condition.
Which are the top treatments for lynch syndrome being explored in clinical trials?
Exciting developments are underway in the clinical trials exploring treatments for Lynch syndrome. Nivolumab, a promising drug, is currently being investigated in four active trials dedicated to this condition. Since its introduction in 2018, it has already made waves with two all-time Lynch syndrome trials. Another contender on the forefront is pembrolizumab, which is involved in three ongoing trials and was first listed as a potential treatment option back in 2015. These groundbreaking therapies hold immense potential to revolutionize the management of Lynch syndrome and improve outcomes for those affected by this hereditary disorder.
What are the most recent clinical trials for lynch syndrome?
Recent clinical trials have brought new possibilities in the treatment of lynch syndrome, a hereditary condition that increases the risk of various cancers. One such trial evaluated Fluorine F 18 L-glutamate Derivative BAY94-9392, an investigational drug aimed at targeting specific genetic mutations associated with lynch syndrome. Another promising study explored Dasatinib, a medication known for its potential to inhibit cancer cell growth. Additionally, Pemigatinib and Dabrafenib were investigated in separate trials as potential treatments for lynch syndrome-related cancers. These innovative approaches offer hope for improved outcomes and tailored therapies for individuals affected by this genetic disorder.
What lynch syndrome clinical trials were recently completed?
Recently completed clinical trials focused on Lynch syndrome have made significant strides in advancing our understanding and treatment of this hereditary condition. One notable trial, sponsored by the National Cancer Institute (NCI), concluded recently and yielded important insights into targeted therapies for Lynch syndrome-related cancers. This breakthrough study holds promise for individuals with Lynch syndrome and highlights the ongoing commitment of researchers to improve outcomes for those affected by this inherited disorder.