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Circadian Protocol for High Blood Pressure

Oregon Health and Science University, Portland, OR
High Blood Pressure+4 More ConditionsCircadian Protocol - Other
Eligibility
25 - 64
All Sexes
What conditions do you have?
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Study Summary

This trial looks at how sleep and the body's natural 24-hour clock affects blood pressure in people with hypertension.

Eligible Conditions
  • High Blood Pressure
  • Cardiovascular Risk
  • Cardiovascular Disease
  • Sleep
  • Circadian Rhythm

Treatment Effectiveness

Phase-Based Effectiveness

1 of 3
N/A

Similar Trials

1
Circadian Study Protocol
1
Constant Routine Protocol
1
Lanadelumab Injection [Takhzyro]

Study Objectives

15 Primary · 3 Secondary · Reporting Duration: 1-2 nights

1-2 nights
Sleep Episodes (At-home Polysomnography)
Sleep Episodes (At-home Polysomonography)
Sleep duration (At-home Polysomnography)
Sleep duration (At-home Polysomonography)
2 days
Magnitude of overnight blood pressure dipping (Overnight sleep vs. rested wakefulness trial)
2 weeks
Ambulatory blood pressure (Sleep regularization trial)
Blood pressure dipping status (Sleep regularization trial)
Sleep regularization trial
7 days
Aldosterone (Circadian and Overnight sleep vs. rested wakefulness trial)
Blood pressure (Circadian and Overnight sleep vs. rested wakefulness trial)
Epinephrine (Circadian and Overnight sleep vs. rested wakefulness trial)
Heart rate (Circadian and Overnight sleep vs. rested wakefulness trial)
Heart rate
Heart rate variability (Circadian and Overnight sleep vs. rested wakefulness trial)
Muscle sympathetic nerve activity (MSNA) (Overnight sleep vs. rested wakefulness trial and circadian trial)
Norepinephrine (Circadian and Overnight sleep vs. rested wakefulness trial)
Angiotensinogen
Vascular endothelial function (Circadian and Overnight sleep vs. rested wakefulness trial)

Trial Safety

Phase-Based Safety

1 of 3

Similar Trials

1
Circadian Study Protocol
1
Constant Routine Protocol
2
Lanadelumab Injection [Takhzyro]

Awards & Highlights

No Placebo Group
All patients enrolled in this trial will receive the new treatment.

Trial Design

1 Treatment Group

Dipping vs non-dipping HTN
1 of 1

Experimental Treatment

32 Total Participants · 1 Treatment Group

Primary Treatment: Circadian Protocol · No Placebo Group · N/A

Dipping vs non-dipping HTNExperimental Group · 5 Interventions: Overnight Sleep Trial, At-home Polysomnography, Circadian Protocol, Rested Wakefulness Trial, Regularized Sleep Schedule · Intervention Types: Other, Other, Other, Other, Behavioral

Trial Logistics

Trial Timeline

Screening: ~3 weeks
Treatment: Varies
Reporting: 1-2 nights

Who is running the clinical trial?

Oregon Health and Science UniversityLead Sponsor
915 Previous Clinical Trials
6,831,467 Total Patients Enrolled
Saurabh S Thosar, PhDPrincipal InvestigatorOregon Health and Science University
2 Previous Clinical Trials
122 Total Patients Enrolled

Eligibility Criteria

Age 25 - 64 · All Participants · 1 Total Inclusion Criteria

Mark “Yes” if the following statements are true for you:
Your body mass index (BMI) falls within the range of 18.5 to 42 kg/m2.
References

Frequently Asked Questions

Does this study require participants to be adults?

"As per the inclusion criteria listed on the study, patients that can enroll are aged 25 to 64. There are 115 other trials for patients younger than 25 and 1168 for seniors." - Anonymous Online Contributor

Unverified Answer

Are recruitment efforts still underway for this experiment?

"Indeed, the clinical trial is currently looking for participants, as shown by the data on clinicaltrials.gov. This study was originally posted on 6/1/2022 and edited on 9/26/2022. 1 centre is looking for 32 individuals to take part in this experiment." - Anonymous Online Contributor

Unverified Answer

How many men and women are currently enrolled in this trial?

"The data available on clinicaltrials.gov show that this study is currently looking for patients to enroll. This trial was first posted on June 1st, 2022 and was most recently updated on September 26th, 2022. A total of 32 patients are needed at 1 trial site." - Anonymous Online Contributor

Unverified Answer
Please Note: These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

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