Study Summary
This trial will help researchers understand why patients with heart failure and preserved ejection fraction (HFpEF) are intolerant to exercise, and if regular physical activity can help improve this.
Eligible Conditions
- Diastolic Heart Failure
Treatment Effectiveness
Effectiveness Progress
Study Objectives
0 Primary · 1 Secondary · Reporting Duration: 12 weeks
12 weeks
femoral blood flow
Trial Safety
Safety Progress
Trial Design
3 Treatment Groups
Afferent effect on fatigue
1 of 3
Afferent effect on hemodynamics
1 of 3
Effect of cardiac rehab
1 of 3
Experimental Treatment
50 Total Participants · 3 Treatment Groups
Primary Treatment: Afferent block · No Placebo Group · N/A
Afferent effect on fatigue
Procedure
Experimental Group · 1 Intervention: Afferent block · Intervention Types: ProcedureAfferent effect on hemodynamics
Procedure
Experimental Group · 1 Intervention: Afferent block · Intervention Types: ProcedureEffect of cardiac rehab
Procedure
Experimental Group · 1 Intervention: Afferent block · Intervention Types: ProcedureTrial Logistics
Trial Timeline
Screening: ~3 weeks
Treatment: Varies
Reporting: 12 weeks
Who is running the clinical trial?
VA Office of Research and DevelopmentLead Sponsor
1,485 Previous Clinical Trials
2,742,169 Total Patients Enrolled
Markus Amann, PhDPrincipal InvestigatorVA Salt Lake City Health Care System, Salt Lake City, UT
2 Previous Clinical Trials
176 Total Patients Enrolled
Eligibility Criteria
Age 21 - 85 · All Participants · 1 Total Inclusion Criteria
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Conditions
Cancer Related
Treatments