Popular Trials
CAR T-cell Therapy
CAR-T Cell Therapy for Lymphoma
This trial tests a new treatment using lab-modified immune cells to target and kill cancer cells in patients with certain types of lymphoma that haven't responded to other treatments. The modified cells are designed to better locate and destroy cancer cells. This new approach extends the capacity of the patient's own immune cells to detect and eliminate cancer cells.
Virus Therapy
Talimogene Laherparepvec + Nivolumab for Skin Cancer and Lymphoma
This trial is testing talimogene laherparepvec and nivolumab to see if they're effective treatments for patients with refractory lymphomas or advanced non-melanoma skin cancers.
Monoclonal Antibodies
Pembrolizumab + Mogamulizumab for Cutaneous T-Cell Lymphoma
This trial is combining two drugs for advanced-stage CTCL, each cycle lasting 6 weeks. Patients will be evaluated regularly and get up to 2 years of treatment if necessary. If a complete response is achieved after 2 cycles, treatment will be continued for an additional 6 months.
Popular Filters
Trials for Cutaneous T-Cell Lymphoma Patients
Janus Kinase (JAK) Inhibitor
Ritlecitinib for Cutaneous T-Cell Lymphoma
This trial is testing a new drug to treat Cutaneous T-Cell Lymphoma, a type of blood cancer that can cause skin rashes/tumors. Tests incl. physical/visual exams, lab tests, skin biopsies, and more. Results will be monitored over 48 weeks.
CAR T-cell Therapy
WU-CART-007 for Blood Cancers
This trial tests WU-CART-007, a modified T-cell therapy, for patients with difficult-to-treat blood cancers. The therapy aims to specifically target and destroy cancer cells without causing harmful side effects. WU-CART-007 has shown potential in treating these types of cancers.
Monoclonal Antibodies
Pembrolizumab + Gemcitabine for Cutaneous T-Cell Lymphoma
This trial is testing a combination of two drugs, pembrolizumab and gemcitabine, to treat patients with mycosis fungoides and Sézary syndrome. Pembrolizumab helps the immune system attack cancer, while gemcitabine kills cancer cells directly. The goal is to see if this combination is more effective than current treatments. IPH4102 is a new antibody specifically developed for treating cutaneous T-cell lymphoma.
Virus Therapy
Letermovir for Preventing Infection in Blood Cancer Patients
This trial studies how well letermovir prevents CMV reactivation in patients with blood cancers treated with alemtuzumab. Letermovir works by stopping the virus from making more copies of itself. The goal is to see if it can effectively prevent CMV infections in these patients. Letermovir is an antiviral drug approved for preventing CMV infections, primarily studied for a few months after treatment.
Monoclonal Antibodies
Mogamulizumab + LD TSEBT for Cutaneous Lymphoma
This trial is testing a combination of two drugs to see if it is effective in treating patients with mycosis fungoides or Sézary syndrome. It will also look at the safety and side effects of the combination.
Trials for CTCL Patients
Janus Kinase (JAK) Inhibitor
Ritlecitinib for Cutaneous T-Cell Lymphoma
This trial is testing a new drug to treat Cutaneous T-Cell Lymphoma, a type of blood cancer that can cause skin rashes/tumors. Tests incl. physical/visual exams, lab tests, skin biopsies, and more. Results will be monitored over 48 weeks.
CAR T-cell Therapy
WU-CART-007 for Blood Cancers
This trial tests WU-CART-007, a modified T-cell therapy, for patients with difficult-to-treat blood cancers. The therapy aims to specifically target and destroy cancer cells without causing harmful side effects. WU-CART-007 has shown potential in treating these types of cancers.
Monoclonal Antibodies
Pembrolizumab + Gemcitabine for Cutaneous T-Cell Lymphoma
This trial is testing a combination of two drugs, pembrolizumab and gemcitabine, to treat patients with mycosis fungoides and Sézary syndrome. Pembrolizumab helps the immune system attack cancer, while gemcitabine kills cancer cells directly. The goal is to see if this combination is more effective than current treatments. IPH4102 is a new antibody specifically developed for treating cutaneous T-cell lymphoma.
Virus Therapy
Letermovir for Preventing Infection in Blood Cancer Patients
This trial studies how well letermovir prevents CMV reactivation in patients with blood cancers treated with alemtuzumab. Letermovir works by stopping the virus from making more copies of itself. The goal is to see if it can effectively prevent CMV infections in these patients. Letermovir is an antiviral drug approved for preventing CMV infections, primarily studied for a few months after treatment.
Monoclonal Antibodies
Mogamulizumab + LD TSEBT for Cutaneous Lymphoma
This trial is testing a combination of two drugs to see if it is effective in treating patients with mycosis fungoides or Sézary syndrome. It will also look at the safety and side effects of the combination.
Trials With No Placebo
Janus Kinase (JAK) Inhibitor
Ritlecitinib for Cutaneous T-Cell Lymphoma
This trial is testing a new drug to treat Cutaneous T-Cell Lymphoma, a type of blood cancer that can cause skin rashes/tumors. Tests incl. physical/visual exams, lab tests, skin biopsies, and more. Results will be monitored over 48 weeks.
CAR T-cell Therapy
WU-CART-007 for Blood Cancers
This trial tests WU-CART-007, a modified T-cell therapy, for patients with difficult-to-treat blood cancers. The therapy aims to specifically target and destroy cancer cells without causing harmful side effects. WU-CART-007 has shown potential in treating these types of cancers.
Monoclonal Antibodies
Pembrolizumab + Gemcitabine for Cutaneous T-Cell Lymphoma
This trial is testing a combination of two drugs, pembrolizumab and gemcitabine, to treat patients with mycosis fungoides and Sézary syndrome. Pembrolizumab helps the immune system attack cancer, while gemcitabine kills cancer cells directly. The goal is to see if this combination is more effective than current treatments. IPH4102 is a new antibody specifically developed for treating cutaneous T-cell lymphoma.
Virus Therapy
Letermovir for Preventing Infection in Blood Cancer Patients
This trial studies how well letermovir prevents CMV reactivation in patients with blood cancers treated with alemtuzumab. Letermovir works by stopping the virus from making more copies of itself. The goal is to see if it can effectively prevent CMV infections in these patients. Letermovir is an antiviral drug approved for preventing CMV infections, primarily studied for a few months after treatment.
Monoclonal Antibodies
Mogamulizumab + LD TSEBT for Cutaneous Lymphoma
This trial is testing a combination of two drugs to see if it is effective in treating patients with mycosis fungoides or Sézary syndrome. It will also look at the safety and side effects of the combination.
View More Related Trials
Frequently Asked Questions
Introduction to sezary syndrome
What are the top hospitals conducting sezary syndrome research?
When it comes to advancing research and treatment options for Sezary Syndrome, several top hospitals are leading the way. In Saint Louis, Washington University School of Medicine has taken a significant role with five ongoing clinical trials focused on this rare form of cutaneous T-cell lymphoma. With nine previous trials under their belt since 2009, they have been dedicated to unraveling the complexities surrounding Sezary Syndrome.
Meanwhile, in Duarte's City of Hope Medical Center, researchers are currently conducting three active clinical trials targeting Sezary Syndrome. Building upon their first recorded trial in 1997, which marked an important milestone in understanding this disease, City of Hope has continued to contribute to the body of knowledge surrounding this condition through a total of nine completed studies.
Stanford Cancer Center in Stanford may have fewer current and past trials compared to other institutions mentioned but still plays a vital role by actively researching Sezary Syndrome with two ongoing clinical trials. Since recording their initial study in 2005, Stanford Cancer Center has conducted four all-time trials that have contributed valuable insights into this complex disease.
Notably situated at Harrison is Memorial Sloan Kettering Westchester where two active clinical tests focus specifically on Sezary Syndrome; these initiatives mark another step forward as they build upon the institution's first recorded trial for this condition which took place in 2018. Similarly contributing towards advancements is Memorial Sloan Kettering Cancer Center located right within New york City itself - also hosting two ongoing sezary syndrome trails while previously having spearheaded investigations from as early as 2009 all adding up to a commendable total countof five such explorations over time
These esteemed medical centers represent beacons of hope for individuals afflicted by Sezary Syndrome and highlight how collaborative efforts across different locations can strive towards understanding and treating rare diseases effectively. Through rigorous clinical trials led by these hospitals mentioned above we stand one step closer towards improved outcomes and brighter future for patients affected by this condition.
Which are the best cities for sezary syndrome clinical trials?
When it comes to Sezary Syndrome clinical trials, several cities stand out as hubs for research and development. New york City tops the list with 9 active trials focusing on treatments like Pembrolizumab, IPH4102, and Treatment Arm. Saint Louis, Missouri follows closely behind with 6 ongoing studies investigating therapies such as Talimogene Laherparepvec and Tulmimetostat (CPI-0209). Philadelphia, Pennsylvania also shows promise with 5 active trials studying IPH4102, Lenalidomide, and Interferon Gamma-1b. Additionally, Stanford in California and Harrison in New York each have 4 active trials exploring various treatment options like LD TSEBT and brentuximab vedotin. These cities offer patients battling Sezary Syndrome access to cutting-edge clinical trials that may redefine the standard of care for this challenging condition.
Which are the top treatments for sezary syndrome being explored in clinical trials?
Clinical trials are paving the way for new hope in the treatment of Sezary syndrome. Leading the charge is pembrolizumab, currently being explored in two active trials dedicated to battling this rare condition. Since its first listing in 2014, it has been involved in a total of six clinical trials for Sezary syndrome. Another promising contender making waves is WU-CART-007, with one ongoing trial and an all-time count of one trial specifically targeting this disease since its introduction in 2023. Also catching attention is mogamulizumab, currently under investigation in one active trial and having participated in a total of six clinical trials for Sezary syndrome since its debut back in 2020. These advancements hold great potential to improve outcomes for patients with Sezary syndrome as researchers continue their tireless efforts to find effective treatments.
What are the most recent clinical trials for sezary syndrome?
Promising advancements in the treatment of Sezary syndrome have emerged from recent clinical trials. One such trial focuses on a new treatment arm specifically tailored for individuals with Sezary syndrome, offering hope for improved outcomes. Additionally, mogamulizumab and pembrolizumab have shown potential as effective therapies in Phase 2 trials for this rare condition. Another intriguing avenue being explored is the use of extracorporeal photopheresis, which has entered both Phase 1 and Phase 2 studies to evaluate its efficacy against Sezary syndrome. Lastly, letermovir has demonstrated promise in a Phase 2 trial conducted earlier in September 2020. These ongoing investigations bring optimism to patients living with Sezary Syndrome by expanding our understanding and options for managing this challenging disease.
What sezary syndrome clinical trials were recently completed?
Recently completed clinical trials have made significant strides in the field of sezary syndrome research, offering hope for patients battling this rare and aggressive form of cutaneous T-cell lymphoma. In February 2020, the National Cancer Institute concluded a trial evaluating the potential of Mogamulizumab as a treatment option. Furthermore, in June 2019, another trial sponsored by the same institute investigated rhIL-15 therapy. Although completed earlier in May 2009, it is worth noting that Stanford University conducted a successful trial focusing on anti-thymocyte globulin. These advancements signify important progress towards developing effective interventions for individuals affected by sezary syndrome.