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Ruxolitinib + Duvelisib for Lymphoma
Study Summary
This trial will study the safety of two drugs, ruxolitinib and duvelisib, in people with lymphoma who have relapsed or are refractory to other treatments.
Eligibility Criteria
Inclusion Criteria
You may be eligible if you check “Yes” for the criteria belowTimeline
Treatment Details
Study Objectives
Outcome measures can provide a clearer picture of what you can expect from a treatment.Side effects data
From 2020 Phase 3 trial • 149 Patients • NCT02038036Trial Design
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- To participate in this clinical trial, you must have specific types of lymphoma or leukemia that have relapsed after at least one prior therapy. You must also have certain laboratory test results within normal ranges and be able to swallow pills. Women who are of reproductive age must have a negative pregnancy test and agree to use birth control during the study and for three months after the last dose of study drug.I am currently being treated for another type of cancer.My lymphoma is a type of T-cell lymphoma confirmed by tests.I have a specific type of T-cell lymphoma.I can take care of myself but might not be able to do heavy physical work.I have had surgery or a condition that affects how drugs are absorbed in my body.I can swallow pills.I haven't had cancer treatment for TCL in the last 14 days.I stopped taking duvelisib or ruxolitinib because of side effects.I have not received a live vaccine in the last 6 weeks.I do not have any severe or uncontrolled health issues.I had a stem cell transplant less than 6 months ago or I need medicine for graft-versus-host disease.I have been treated for tuberculosis within the last 2 years.My cancer has spread to my brain or its coverings.I am not taking high doses of steroids or certain medications.I am 18 years old or older.I have a history of liver disease or I currently abuse alcohol.I am not taking any strong medications that affect liver enzymes.I cannot or do not want to take medication to prevent infections.
- Group 1: Ruxolitinib and Duvelisib
- No Placebo-Only Group - All patients enrolled in this study will receive some form of active treatment.
- Screening: It may take up to 3 Weeks to process to see if you qualify in this trial.
- Treatment: The duration you will receive the treatment varies.
- Follow Ups: You may be asked to continue sharing information regarding the trial for 6 Months after you stop receiving the treatment.
Frequently Asked Questions
Are there any open slots available for this clinical trial?
"According to clinicaltrials.gov, this research project is currently recruiting participants and has been since August 12th 2021. The most recent update was recorded on November 14th 2022."
Has Ruxolitinib been studied in any other medical experiments?
"Ruxolitinib has been in clinical research since 2002, with 106 completed trials. At present, 112 studies are seeking participants and most have sites located in Miami, Florida."
What is the total participant count for this clinical experiment?
"Affirmative. Clinicaltrials.gov states that enrollment for this clinical trial is currently open, which was first posted on August 12th 2021 and modified most recently on November 14th 2022. 52 participants are needed across 9 different clinical sites."
What maladies has Ruxolitinib been indicated to alleviate?
"Ruxolitinib is a common pharmaceutical for the treatment of lymphoma, follicular. Additionally, this drug can be employed to manage polycythemia vera, polycythemia and cases that are resistant or intolerant to hydroxyurea."
Are there any outposts in North America conducting this clinical experiment?
"The recruitment of participants is being conducted in 9 different locations; these include the University of Miami (Data Collection Only) located in Miami, Memorial Sloan Kettering Nassau (Limited Protocol Activities) situated in Uniondale and Memorial Sloan Kettering Monmouth (Limited Protocol Activities) based in Middletown."
Has the FDA sanctioned Ruxolitinib for therapeutic purposes?
"Ruxolitinib's risk profile is rated 1 on the Power scale due to limited data concerning its efficacy and safety, as it is in Phase 1 clinical trials."
Who else is applying?
What state do they live in?
What site did they apply to?
What portion of applicants met pre-screening criteria?
How many prior treatments have patients received?
How responsive is this trial?
Typically responds via
Most responsive sites:
- Memorial Sloan Kettering Westchester (Limited Protocol Activities): < 48 hours
Average response time
- < 2 Days
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