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Chemoimmunotherapy + Stem Cell Transplant for NK T-cell Lymphoma/Leukemia
Study Summary
This trial is studying two different chemotherapy combinations followed by stem cell transplant in treating patients with newly diagnosed stage III-IV non-Hodgkin lymphoma or leukemia.
Eligibility Criteria
Inclusion Criteria
You may be eligible if you check “Yes” for the criteria belowTimeline
Treatment Details
Study Objectives
Outcome measures can provide a clearer picture of what you can expect from a treatment.Side effects data
From 2016 Phase 2 trial • 303 Patients • NCT02004262Trial Design
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Who is running the clinical trial?
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- I have only used steroids or radiation in emergencies.My lymphoma is at an advanced stage (III or IV).I have an active brain or spinal cord disease.My condition is ALK positive or negative Anaplastic Large Cell Lymphoma.I have been recently diagnosed with a specific type of blood cancer.I am currently taking medication that affects liver enzyme levels.I am on medication that is sensitive to changes in my body's enzyme levels.My liver is functioning well, with normal bilirubin and ALT levels.I can breathe normally without discomfort and my oxygen level is above 92%.I am currently pregnant.I weigh at least 10 kilograms.I am currently taking medication that affects liver enzyme levels.My cancer is in the early stages (stage I or II).I have received chemotherapy for my current non-Hodgkin lymphoma diagnosis.
- Group 1: Cohort 1
- Group 2: Cohort 2
- All Individual Drugs Already Approved - Therapies where all constituent drugs have already been approved are likely to have better-understood side effect profiles.
- Approved for 60 Other Conditions - This treatment demonstrated efficacy for 60 other conditions.
- No Placebo-Only Group - All patients enrolled in this study will receive some form of active treatment.
- Screening: It may take up to 3 Weeks to process to see if you qualify in this trial.
- Treatment: The duration you will receive the treatment varies.
- Follow Ups: You may be asked to continue sharing information regarding the trial for 6 Months after you stop receiving the treatment.
Frequently Asked Questions
Are there open positions for participants in this trial at present?
"As per the clinicaltrials.gov entry, this investigation is now enrolling individuals; it was first advertised on March 1st 2019 and recently revised on September 26th 2022."
Does the research protocol encompass individuals aged 85 and younger?
"Patients wishing to be included in this medical trial must fall between the ages of 1 Year and 31 Years. Notably, there are 1059 clinical trials for minors and 4012 available for those over 65 years old."
Is this investigation something of a pioneering endeavor?
"Since 1997, cyclophosphamide has undergone considerable examination. The first major trial was conducted by Alfacell in the same year and entailed 300 participants. Subsequently, Phase 3 drug approval was granted to this medication before it began its global prevalence; currently 1881 trials are actively taking place across 86 countries and 3466 cities."
How extensive is the recruitment for this research project?
"Affirmative, the clinical trial is actively recruiting according to information hosted on clinicaltrials.gov. The initial posting was made on March 1st 2019 with a recent edit taking place on September 26th 2022. 40 patients are needed at two distinct locations for this study."
What uses is cyclophosphamide primarily employed for?
"Cyclophosphamide is typically used to treat macular edema, and may also be beneficial for patients with conditions such as eye inflammation, ulcerative colitis, or varicella-zoster virus acute retinal necrosis."
Who is eligible to take part in this research experiment?
"To be a successful applicant, individuals ought to have NK-cell leukemia and must fall between the ages of one year and thirty-one. As this trial is in search of around 40 patients, interested parties should make haste to apply."
What kind of research has been done pertaining to cyclophosphamide?
"Cyclophosphamide was initially investigated in 1997 at Spectrum Health Hospital - Butterworth Campus. Subsequently, there have been 3,429 concluded studies and 1,881 ongoing experiments centered around the drug; many of these taking place in San Francisco, California."
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