Study Summary
This trial looks at how exercise affects people with sickle cell trait. It measures changes in the body before and after exercise to see how different biomarkers are affected. This could help explain why some people with sickle cell trait have complications after strenuous exercise.
Treatment Effectiveness
Effectiveness Progress
Study Objectives
15 Primary · 0 Secondary · Reporting Duration: Immediately before, immediately after, & 24 hours after a single bout of submaximal exercise on a treadmill
Hour 24
Change in 11-dehydrothrombaxaneB2 (11-DTXB2) level
Change in C-reactive protein (CRP) level
Change in D-dimer level
Change in antithrombin III (ATIII) level
Change in complete urinalysis results
Change in creatine kinase (CK) level
Change in erythrocyte morphology amounts
Change in erythrocyte sedimentation rate (ESR) level
Change in fibrin monomer level
Change in haptoglobin level
Change in microalbumin level
Change in potassium (K+) level
Change in reticulocyte count
Change in serum myoglobin level
Change in urine myoglobin level
Trial Safety
Safety Progress
Trial Design
2 Treatment Groups
Control Group
1 of 2
SCT Group
1 of 2
Active Control
Experimental Treatment
20 Total Participants · 2 Treatment Groups
Primary Treatment: Exercise · No Placebo Group · N/A
SCT Group
Other
Experimental Group · 1 Intervention: Exercise · Intervention Types: OtherControl Group
Other
ActiveComparator Group · 1 Intervention: Exercise · Intervention Types: OtherTrial Logistics
Trial Timeline
Screening: ~3 weeks
Treatment: Varies
Reporting: immediately before, immediately after, & 24 hours after a single bout of submaximal exercise on a treadmill
Who is running the clinical trial?
St. Louis UniversityLead Sponsor
187 Previous Clinical Trials
38,132 Total Patients Enrolled
American Society for Clinical Laboratory ScienceUNKNOWN
Tim R Randolph, PhDPrincipal InvestigatorSt. Louis University
Eligibility Criteria
Age 18 - 70 · All Participants · 5 Total Inclusion Criteria
Mark “Yes” if the following statements are true for you:You have sickle cell trait (AS).
You have sickle cell trait (AS).
This criterion is incomplete and requires more information to provide a simplified summary.
You must not have the sickle cell trait (AA).
You are between 18 and 70 years old.