VAD044 for Hereditary Hemorrhagic Telangiectasia
Trial Summary
Will I have to stop taking my current medications?
The trial does not specify if you need to stop taking your current medications, but you cannot participate if you have used drugs with anti-angiogenic properties in the past 8 weeks or if you require therapeutic anticoagulation.
What is the purpose of this trial?
This trial is testing a new medication called VAD044 to see if it can help adults with Hereditary Hemorrhagic Telangiectasia (HHT). The study will compare two different doses of VAD044 to check its safety and effectiveness. Participants will be assigned to one of the groups, and neither they nor the researchers will know which treatment they are receiving.
Research Team
Damien Picard
Principal Investigator
Vaderis Therapeutics AG
Eligibility Criteria
This trial is for adults with Hereditary Hemorrhagic Telangiectasia (HHT) who experience several nosebleeds per week and have anemia. Participants must be vaccinated against or have antibodies for COVID-19. Those on blood thinners, recent anti-angiogenic drugs, with certain diabetes conditions, active infections including COVID-19, or recent nasal procedures cannot join.Inclusion Criteria
Exclusion Criteria
Timeline
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants are randomized to receive either 30mg VAD044, 40mg VAD044, or placebo once daily
Follow-up
Participants are monitored for safety and effectiveness after treatment
Open-label extension
Participants may opt into continuation of treatment with VAD044 for long-term safety and efficacy assessment
Treatment Details
Interventions
- VAD044
Find a Clinic Near You
Who Is Running the Clinical Trial?
Vaderis Therapeutics AG
Lead Sponsor