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Aspirin for Fallopian Tube Cancer

Phase < 1

Waitlist Available

Led By Laura Holman

Research Sponsored by University of Oklahoma

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Women undergoing gynecologic surgery for presumed benign indications that includes the removal of their fallopian tubes. This may include sterilization procedures, hysterectomy or partial or full adnexectomy.

Be older than 18 years old

Timeline

Screening 3 weeks

Treatment Varies

Follow Up 5 years

Awards & highlights

Study Summary

This trial will study the effect of aspirin on the fallopian tubes of women who are scheduled to have them removed. Women will take a low dose of aspirin for two weeks prior to surgery, and a portion of the removed tubes will be collected for future research.

Who is the study for?

This trial is for women over 21 who are having surgery to remove their fallopian tubes and have completed childbearing. They should not be at high risk for fallopian tube cancer, nor have a history of gynecologic cancer, bleeding disorders, or regular use of NSAIDs or aspirin. Women with gastritis, peptic ulcers, aspirin allergies, asthma with nasal polyps are excluded.Check my eligibility

What is being tested?

The study tests the effects of taking low-dose aspirin (81 mg) daily for two weeks before surgery on the biological and immunological aspects of normal fallopian tube tissue. The tissues removed during surgery will be analyzed to assess these changes.See study design

What are the potential side effects?

Potential side effects from low-dose aspirin may include increased risk of bleeding, gastrointestinal issues like stomach pain or heartburn, allergic reactions in those sensitive to NSAIDs or aspirin.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

Select...

I am having surgery for a non-cancerous gynecologic condition that includes removing my fallopian tubes.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ 5 years

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~5 years

This trial's timeline: 3 weeks for screening, Varies for treatment, and 5 years for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

Number of subjects who exhibited alterations in the fallopian tube immune microenvironment

Number of subjects who exhibited changes in transcriptome profile compared to control specimens

Number of subjects who exhibited less carcinogenic potential than control specimens

Side effects data

From 2011 Phase 2 & 3 trial • 93 Patients • NCT01586975

Nose bleeds

GI bleeding

Clinical Stroke

100%

80%

60%

40%

20%

Study treatment Arm

Aspirin 81 mg

Aspirin >300 mg

Clopidogrel 75 mg

Trial Design

1Treatment groups

Experimental Treatment

Group I: AspirinExperimental Treatment1 Intervention

Subjects will take 81mg tablets of aspirin daily for 14 days prior to surgery for removal of fallopian tubes.

Treatment

First Studied

Drug Approval Stage

How many patients have taken this drug

Aspirin 81 mg

2007

Completed Phase 4

~810

0 / 1Eligibility criteria met

Find a Location

Who is running the clinical trial?

University of OklahomaLead Sponsor

455 Previous Clinical Trials

97,592 Total Patients Enrolled

3 Trials studying Ovarian Cancer

129 Patients Enrolled for Ovarian Cancer

Laura HolmanPrincipal InvestigatorStephenson Cancer Center, University of Oklahoma Health Sciences Center

Media Library

Aspirin 81 mg Clinical Trial Eligibility Overview. Trial Name: NCT03771651 — Phase < 1

Ovarian Cancer Research Study Groups: Aspirin

Ovarian Cancer Clinical Trial 2023: Aspirin 81 mg Highlights & Side Effects. Trial Name: NCT03771651 — Phase < 1

Aspirin 81 mg 2023 Treatment Timeline for Medical Study. Trial Name: NCT03771651 — Phase < 1

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What is the scope of participation for this research endeavor?

"Affirmative, the clinicaltrial.gov portal reveals that this medical trial is presently recruiting patients. Initially posted on March 1st 2019, it was most recently updated on April 11th 2022 and requires 75 participants from a single location to complete their study."

Answered by AI

Do I satisfy the requirements to join this experiment?

"The scope of this trial encompasses 75 female patients, aged between 18 and 99, with a current fallopian tube infection. Moreover, the participants must have completed their reproductive goals, be over 21 years old, considered to have low risk for prevalent cancer in the tubes (excluding those undergoing surgery due to BRCA mutation or other known hereditary circumstances), and not possess a family history of ovarian cancer within first-degree relatives."

Answered by AI

Can individuals currently sign up to participate in this experiment?

"As indicated by current records on clinicaltrials.gov, this medical trial is seeking participants. It was initially published March 1st 2019 and the most recent update occured April 11th 2022."

Answered by AI

What conditions can be alleviated with Aspirin 81 mg?

"Aspirin 81 mg is an appropriate medication for treating percutaneous coronary intervention (pci), dental procedures, and inflammation."

Answered by AI

Are individuals aged thirty and older eligible to partake in this investigation?

"The criteria for enrollment into this medical trial is that potential participants are between the ages of 18 and 99. Currently available research suggests 19 clinical trials accept minors while 331 have been designed to target adults 65 years or older."

Answered by AI

Has this clinical research been conducted before?

"Since its first study in 2005, sponsored by Abbott and involving 15480 participants, Aspirin 81 mg has been widely studied. Currently there are 167 active studies of this drug conducted around the globe across 1398 cities and 57 nations that have led to Phase 4 approval."

Answered by AI

Recent research and studies

clinicaltrials.govStudy

Short Term Aspirin on the Biologic and Immunologic Changes of the Fallopian Tube

2019. "Short Term Aspirin on the Biologic and Immunologic Changes of the Fallopian Tube". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT03771651.

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