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Supine vs Upright Exercise for Hepatopulmonary Syndrome
N/A
Recruiting
Led By Samir Gupta, MD, MSc
Research Sponsored by Unity Health Toronto
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial Must have
Diagnosis of moderate HPS (defined by liver disease, hypoxemia [PaO2 < 80 mmHg and AaDo2 (alveolar-arterial PO2 difference) ≥ 15 mmHg or ≥ 20 mmHg if age > 64 years] and IPVD (intrapulmonary vasodilatations) as shown by contrast echocardiography])
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 12 months
Awards & highlights
Study Summary
This trial will compare the effects of supine and upright exercise in patients with hepatopulmonary syndrome and orthodeoxia.
Who is the study for?
This trial is for patients with moderate Hepatopulmonary Syndrome (HPS) and orthodeoxia, which means they have liver disease with low oxygen levels and a drop in oxygen when sitting up. They must be able to use a cycle ergometer without significant heart, lung, or other health issues that would prevent exercise.Check my eligibility
What is being tested?
The study compares the effects of exercising while lying down (supine exercise) versus sitting up (upright exercise) on patients with HPS and orthodeoxia. It aims to see if supine position allows them to exercise longer due to better oxygen levels.See study design
What are the potential side effects?
While not explicitly stated, potential side effects may include discomfort from prolonged supine positioning during exercise or fatigue related to increased exertion compared to their usual capacity.
Eligibility Criteria
Inclusion Criteria
You may be eligible if you check “Yes” for the criteria belowSelect...
I have moderate HPS with specific liver and lung conditions confirmed by tests.
Timeline
Screening ~ 3 weeks3 visits
Treatment ~ Varies
Follow Up ~ 12 months
Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~12 months
Treatment Details
Study Objectives
Outcome measures can provide a clearer picture of what you can expect from a treatment.Primary outcome measures
Stopping time (tLIM)
Secondary outcome measures
Arterial Oxygen Saturation
Cardiac output
Change in Inspiratory Capacity
+16 moreTrial Design
2Treatment groups
Experimental Treatment
Active Control
Group I: Intervention - Supine ExerciseExperimental Treatment1 Intervention
Participants will perform supine exercise on a cycle ergometer. The opposite test will be completed within 4 weeks.
Group II: Control - Upright ExerciseActive Control1 Intervention
Participants will perform upright exercise on a cycle ergometer. The opposite test will be completed within 4 weeks.
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Who is running the clinical trial?
Unity Health TorontoLead Sponsor
538 Previous Clinical Trials
447,713 Total Patients Enrolled
1 Trials studying Hepatopulmonary Syndrome
9 Patients Enrolled for Hepatopulmonary Syndrome
Samir Gupta, MD, MScPrincipal InvestigatorClinician-Scientist
Media Library
Eligibility Criteria:
This trial includes the following eligibility criteria:- You have a significant breathing problem that makes it hard for you to exhale properly.I have moderate HPS with specific liver and lung conditions confirmed by tests.Your blood oxygen level drops by more than 4 mmHg when you change from lying down to standing up.I don't have severe heart or lung conditions that would make exercise tests unsafe.You have high blood pressure in the vessels of your lungs, as measured by specific tests.I have been diagnosed with serious heart artery problems.I have a condition that stops me from using a stationary bike.I have moderate to severe fluid buildup in my abdomen.
Research Study Groups:
This trial has the following groups:- Group 1: Intervention - Supine Exercise
- Group 2: Control - Upright Exercise
Awards:
This trial has 1 awards, including:- No Placebo-Only Group - All patients enrolled in this study will receive some form of active treatment.
Timeline:
This trial has the following timeline:- Screening: It may take up to 3 Weeks to process to see if you qualify in this trial.
- Treatment: The duration you will receive the treatment varies.
- Follow Ups: You may be asked to continue sharing information regarding the trial for 6 Months after you stop receiving the treatment.
Frequently Asked Questions
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
Is the enrollment period for this trial still ongoing?
"Affirmative. Clinicaltrials.gov data verifies that this scientific research is currently enrolling applicants, with the first post on July 24th 2019 and most recent update taking place May 17th 2022. The study seeks 10 volunteers from one medical facility."
Answered by AI
What is the current enrollment count for this clinical trial?
"Affirmative. According to information posted on clinicaltrials.gov, this clinical trial is actively searching for participants and was initially published on July 24th 2019 before the most recent update took place May 17th 2022. Currently 10 individuals are slated for enrolment at a single site."
Answered by AI
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