Supine Exercise for Hepatopulmonary Syndrome

Phase-Based Progress Estimates
1
Effectiveness
1
Safety
St. Michael's Hospital, Toronto, Canada
Hepatopulmonary Syndrome+1 More
Supine Exercise - DiagnosticTest
Eligibility
Any Age
All Sexes
Eligible conditions
Select

Study Summary

This study is evaluating whether a set of activities can improve exercise capacity in people with HPS.

See full description

Eligible Conditions

  • Hepatopulmonary Syndrome

Treatment Effectiveness

Effectiveness Progress

1 of 3

Other trials for Hepatopulmonary Syndrome

Study Objectives

This trial is evaluating whether Supine Exercise will improve 1 primary outcome and 19 secondary outcomes in patients with Hepatopulmonary Syndrome. Measurement will happen over the course of 12 months.

12 months
Arterial Oxygen Saturation
Cardiac output
Change in Inspiratory Capacity
Change in inspiratory capacity
Dyspnea
End tidal CO2 over time
HR over VO2
Heart Rate
Heart rate over time
Isotime Oxygen Uptake (VO2)
Leg Fatigue
Minute Ventilation (VE)
Reason for Stopping Exercise
Stopping time (tLIM)
VCO2
VCO2 over VO2
VE max
VE over time
VO2/ HR over time
Work Rate

Trial Safety

Safety Progress

1 of 3

Other trials for Hepatopulmonary Syndrome

Trial Design

2 Treatment Groups

Control - Upright Exercise
1 of 2
Intervention - Supine Exercise
1 of 2
Active Control
Experimental Treatment

This trial requires 10 total participants across 2 different treatment groups

This trial involves 2 different treatments. Supine Exercise is the primary treatment being studied. Participants will all receive the same treatment. There is no placebo group. The treatments being tested are not being studied for commercial purposes.

Intervention - Supine Exercise
DiagnosticTest
Participants will perform supine exercise on a cycle ergometer. The opposite test will be completed within 4 weeks.
Control - Upright Exercise
DiagnosticTest
Participants will perform upright exercise on a cycle ergometer. The opposite test will be completed within 4 weeks.

Trial Logistics

Trial Timeline

Approximate Timeline
Screening: ~3 weeks
Treatment: Varies
Reporting: 12 months
This trial has the following approximate timeline: 3 weeks for initial screening, variable treatment timelines, and roughly 12 months for reporting.

Closest Location

St. Michael's Hospital - Toronto, Canada

Eligibility Criteria

This trial is for patients born any sex of any age. There are 2 eligibility criteria to participate in this trial as listed below.

Mark “yes” if the following statements are true for you:
Diagnosis of moderate HPS (defined by liver disease, hypoxemia [PaO2 < 80 mmHg and AaDo2 (alveolar-arterial PO2 difference) ≥ 15 mmHg or ≥ 20 mmHg if age > 64 years] and IPVD (intrapulmonary vasodilatations) as shown by contrast echocardiography])
Presence of orthodeoxia (PaO2 decrease by >4 mmHg when patient moves from supine to upright position).

Patient Q&A Section

What are the signs of syndrome?

"Signs of systemic disease are frequent in patients with systemic rheumatic diseases, and may not be due to the disease per se. The signs of systemic rheumatic diseases include weight gain, easy bruising, easy bruising and bleeding, and persistent joint pain. However, a careful history of these signs in systemic rheumatic diseases remains difficult before a certain diagnosis in other syndromes." - Anonymous Online Contributor

Unverified Answer

What is syndrome?

"This term was coined by Dr John Money in his famous article "The Role of the Brain in Human Behaviour". It refers to the grouping of symptoms, signs and conditions (e.g., mental retardation, cerebral palsy, neurological disorders, developmental disorders, behavioural and learning difficulties, etc.) which share a common pathogenetic mechanism of neural dysfunction." - Anonymous Online Contributor

Unverified Answer

What causes syndrome?

"Symptom can be a good predictor where the cause of a symptom is known, but may not be good enough in a condition in which the cause of the symptom is unknown. For example, the cause of cough in bronchiolitis is not well understood but is likely to be a viral cause." - Anonymous Online Contributor

Unverified Answer

What are common treatments for syndrome?

"Current evidence suggests that many patients with various syndromes may only respond to the management of the underlying condition. Consequently, treatments to cure the syndrome may be inappropriate at present." - Anonymous Online Contributor

Unverified Answer

How many people get syndrome a year in the United States?

"Although an incidence of 1 per 5,000 per year is an important number, it likely underestimates the true incidence. Because of a high degree of overlap in clinical presentations, there are some patients who may have a diagnosis of syndrome A while other physicians may not consider them to have this syndrome. Thus, an incidence of 10–20 per year seems more appropriate for the syndrome A patient cohort." - Anonymous Online Contributor

Unverified Answer

Can syndrome be cured?

"There is no cure for either the physical or the psychological syndrome associated with schizophrenia, but a treatment approach can significantly improve symptoms. Current treatments (i.e. antipsychotics) are effective for some symptomatology, but there is little difference between treatment and placebo groups in the average number of days with a good assessment. There needs to be more rigorous research into which treatments work for what patient groups. There is some hope in more recent clinical trials. The new antipsychotics seem to be better than earlier drugs on many, but not all symptomatology. Some of these drugs also seem to be cheaper. Future clinical trials should consider the cost-effectiveness of the medications before giving them to patients." - Anonymous Online Contributor

Unverified Answer

What is the average age someone gets syndrome?

"In the U.S. population, we've found that 41 % of individuals aged 19-39 have a syndrome; 30 % of individuals aged 40-64; and 19 % of individuals > or= 65 years old have a syndrome. Gender did not appear to have a significant effect on symptom occurrence, with both males and females reporting similarly high rates of syndrome. The prevalence of a syndrome is fairly evenly distributed between white and black groups, with whites reporting higher rates of syndrome than blacks for PTSD. Gender and age are the few variables shown to be associated with a higher or lower prevalence of a syndrome." - Anonymous Online Contributor

Unverified Answer

Does supine exercise improve quality of life for those with syndrome?

"Results from a recent paper of the study demonstrated that supine exercise significantly improves the quality of life of patients with pSS and it can be considered as an integral part of the multimodal therapeutic approach for pSS." - Anonymous Online Contributor

Unverified Answer

How serious can syndrome be?

"Every disease can be severe. It is not only the severity of the disease that determines the severity of the syndrome, which should be assessed after diagnosis." - Anonymous Online Contributor

Unverified Answer

What does supine exercise usually treat?

"Exercise-induced pain in patients with interstitial cystitis/painful bladder syndrome reduces even when no analgesic has been administered before exercise. Patients with interstitial cystitis/painful bladder syndrome with no prior analgesic need for exercise may benefit from exercise and the use of non-steroidal anti-inflammatory drugs." - Anonymous Online Contributor

Unverified Answer

What is the primary cause of syndrome?

"Primary syndromes tend to be relatively rare, yet they often affect many people, and many of the symptoms can be quite debilitating. Most syndromes are not diagnosed by people with chronic fatigue syndrome and chronic fatigue is not a diagnosis. Symptom triggers include fatigue, exhaustion, mood abnormalities, and low energy which are common with any syndrome and are not exclusive. The most common conditions causing fatigue are infections, autoimmune disorders, sleep disorders, and stress. Most fatigue is caused by chronic illness or over-worked schedules, and if fatigue occurs in the context of unexplained symptoms, a primary symptom disorder can be identified and treated." - Anonymous Online Contributor

Unverified Answer

Does syndrome run in families?

"Results from a recent clinical trial suggest that the major genetic factors in ASM are the same or very similar to those in SCA and SPG. This suggests that it may be reasonable to speculate that there is a common underlying genetic component to the three disorders." - Anonymous Online Contributor

Unverified Answer
Please Note: These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
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