Exercise for Down Syndrome

Phase-Based Progress Estimates
2
Effectiveness
3
Safety
Disability, Health & Social Policy Building; Integrative Physiology Lab, Chicago, IL
Down Syndrome+1 More
Exercise - Other
Eligibility
18 - 65
All Sexes
What conditions do you have?
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Study Summary

Down syndrome (DS) is a chromosomal condition that occurs in approximately 1 in 800 births worldwide, and causes impairments in physical function, including a reduced work capacity (as measured by VO2peak or aerobic capacity). Work capacity is important for activities of daily living, in order to live longer, healthier lives. Reduced work capacity stems in large part from autonomic dysfunction, which has been described in individuals with DS. Individuals with DS experience reduced sympathetic and parasympathetic control, which results in alterations in resting heart rate, blood pressure, and attenuated responses to sympathoexcitatory stimuli. Autonomic dysfunction may impair the ability to regulate blood flow and blood pressure to working muscles during exercise, which may cause a mismatch between oxygen supply and demand, further compromising the already reduced work capacity observed in individuals with DS. Utilization of a large muscle mass exercise, such as lower-limb dynamic exercise (similar to walking), requires a large shift in blood flow to match metabolic demand and allows the opportunity to evaluate blood flow regulation. Conversely, examination of the large changes in pressure in response to isometric exercise (i.e., a sustained contraction), allows for examination of the exercise pressor reflex as evoked by the isometric contraction. Thus, by comprehensively evaluating blood flow and blood pressure regulation, our work will further elucidate the mechanisms that underlay the reduced work capacity in individuals with DS. Improvement of overall work capacity for a population with reduced work capacity will guide future studies and exercise interventions aimed at helping to improve independence and quality of life, ultimately allowing individuals with DS to live longer, healthier lives. Aim 1 (Dynamic Exercise): To examine the effects of an acute bout of dynamic leg kicking at both relative and absolute intensity workloads on femoral blood flow to both exercising and non-exercising muscle, in individuals with and without DS. Aim 2 (Isometric Exercise): To examine the exercise pressor response to lower limb isometric exercise in individuals with and without DS.

Eligible Conditions

  • Down Syndrome

Treatment Effectiveness

Effectiveness Progress

2 of 3
This is further along than 85% of similar trials

Study Objectives

2 Primary · 0 Secondary · Reporting Duration: During study visit 2, blood pressure will be measured as a change from baseline blood pressure to leg contraction blood pressure. It will also be measured as a change in baseline blood pressure to post leg contraction blood flow.

During study visit 1, lower limb blood flow will be measured as a change from baseline to blood flow during leg contraction. It will also be measured as a change from baseline to post leg contraction blood flow.
Blood Flow
During study visit 2, blood pressure will be measured as a change from baseline blood pressure to leg contraction blood pressure. It will also be measured as a change in baseline blood pressure to post leg contraction blood flow.
Blood Pressure

Trial Safety

Safety Progress

3 of 3
This is further along than 85% of similar trials

Trial Design

2 Treatment Groups

Dynamic Exercise
1 of 2
Static Exercise
1 of 2
Experimental Treatment

36 Total Participants · 2 Treatment Groups

Primary Treatment: Exercise · No Placebo Group · Phase 3

Dynamic Exercise
Other
Experimental Group · 1 Intervention: Exercise · Intervention Types: Other
Static Exercise
Other
Experimental Group · 1 Intervention: Exercise · Intervention Types: Other

Trial Logistics

Trial Timeline

Approximate Timeline
Screening: ~3 weeks
Treatment: Varies
Reporting: during study visit 2, blood pressure will be measured as a change from baseline blood pressure to leg contraction blood pressure. it will also be measured as a change in baseline blood pressure to post leg contraction blood flow.

Trial Background

Sara Rae Sherman, Graduate Student
Principal Investigator
University of Illinois at Chicago
Closest Location: Disability, Health & Social Policy Building; Integrative Physiology Lab · Chicago, IL
Photo of Chicago  1Photo of Chicago  2Photo of Chicago  3
N/AFirst Recorded Clinical Trial
1 TrialsResearching Down Syndrome
0 CompletedClinical Trials

Eligibility Criteria

Age 18 - 65 · All Participants · 6 Total Inclusion Criteria

Mark “yes” if the following statements are true for you:
You are 18-45 years old and apparently healthy.
You have a congenital heart defect for individuals with Down syndrome.

About The Reviewer

Michael Gill preview

Michael Gill - B. Sc.

First Published: October 9th, 2021

Last Reviewed: August 12th, 2022

Michael Gill holds a Bachelors of Science in Integrated Science and Mathematics from McMaster University. During his degree he devoted considerable time modeling the pharmacodynamics of promising drug candidates. Since then, he has leveraged this knowledge of the investigational new drug ecosystem to help his father navigate clinical trials for multiple myeloma, an experience which prompted him to co-found Power Life Sciences: a company that helps patients access randomized controlled trials.