Preservative Free Morphine for Depression

Phase-Based Progress Estimates
3
Effectiveness
3
Safety
Depression+4 More
Preservative Free Morphine - Drug
Eligibility
18+
Female
What conditions do you have?
Select

Study Summary

This trial is testing whether preservative-free morphine or placebo given after delivery can help with pain relief for patients who have had a neuraxial anesthetic.

Eligible Conditions
  • Depression
  • Opioid Consumption
  • Postpartum Depression
  • Pain

Treatment Effectiveness

Effectiveness Progress

3 of 3
This is further along than 93% of similar trials

Study Objectives

1 Primary · 4 Secondary · Reporting Duration: 24 hours

1 week
Number of participants with breast feeding success
24 hours
Obstetric Quality of Recovery Score (OBSQ10)
Opioid Consumption
up to 24 hours
Pain Score
up to 6 weeks
Edinburgh Postnatal Depression Scale (EPDS)

Trial Safety

Safety Progress

3 of 3
This is further along than 85% of similar trials

Trial Design

2 Treatment Groups

Morphine
1 of 2
Saline
1 of 2
Experimental Treatment
Non-Treatment Group

140 Total Participants · 2 Treatment Groups

Primary Treatment: Preservative Free Morphine · Has Placebo Group · Phase 4

Morphine
Drug
Experimental Group · 1 Intervention: Preservative Free Morphine · Intervention Types: Drug
Saline
Drug
PlaceboComparator Group · 1 Intervention: Saline · Intervention Types: Drug

Trial Logistics

Trial Timeline

Approximate Timeline
Screening: ~3 weeks
Treatment: Varies
Reporting: 24 hours

Who is running the clinical trial?

Icahn School of Medicine at Mount SinaiLead Sponsor
771 Previous Clinical Trials
479,686 Total Patients Enrolled
32 Trials studying Depression
2,772 Patients Enrolled for Depression
Daniel Katz, MDPrincipal Investigator - Icahn School of Medicine at Mount Sinai
Icahn School Of Medicine At Mount Sinai, Icahn School of Medicine at Mount Sinai, Mount Sinai Hospital
4 Previous Clinical Trials
849 Total Patients Enrolled

Eligibility Criteria

Age 18+ · Female Participants · 0 Total Inclusion Criteria

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About The Reviewer

Michael Gill preview

Michael Gill - B. Sc.

First Published: October 10th, 2021

Last Reviewed: October 21st, 2022

Michael Gill holds a Bachelors of Science in Integrated Science and Mathematics from McMaster University. During his degree he devoted considerable time modeling the pharmacodynamics of promising drug candidates. Since then, he has leveraged this knowledge of the investigational new drug ecosystem to help his father navigate clinical trials for multiple myeloma, an experience which prompted him to co-found Power Life Sciences: a company that helps patients access randomized controlled trials.

Who else is applying?

What state do they live in?
Wisconsin100.0%
How old are they?
18 - 65100.0%
What site did they apply to?
Mount Sinai Hospital100.0%
What portion of applicants met pre-screening criteria?
Met criteria100.0%