Clinical Trials in Orlando, FL

View medical research that is recruiting in Orlando, Florida. Filter by phase, distance, and inclusion criteria to find cutting edge treatments & access premium care.

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Orlando, Florida

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Pozelimab + Cemdisiran

The primary objective is: To evaluate the effect of pozelimab + cemdisiran on daily functioning that is impacted by signs and symptoms in patients with symptomatic generalized myasthenia gravis (gMG) The secondary objectives of the study are: To evaluate the effect of pozelimab + cemdis…

Adenovirus serotype 26 (Ad26)-based respiratory syncytial virus (RSV). preF

This study is evaluating whether a vaccine can prevent RSV-mediated LRTD.

This study is evaluating whether a combination of drugs may help treat colorectal cancer.

This study will compare the efficacy and safety of belzutifan + lenvatinib versus cabozantinib in participants with advanced renal cell carcinoma (RCC) with clear cell component after prior therapy. The primary hypothesis is that belzutifan + lenvatinib is superior to cabozantinib in term…

This study is evaluating whether a combination of two drugs may help treat patients with advanced melanoma.

GID SVF-2 Device System

This study is evaluating whether a single injection of fat may help treat osteoarthritis of the knee.

This study is evaluating whether a drug may help treat certain types of cancer.

Tyrosine Kinase Inhibitor

This study is evaluating whether stopping tyrosine kinase inhibitors will help patients with chronic myeloid leukemia in chronic phase continue or re-achieve molecular remission.

This study is evaluating whether a drug may help treat Crohn's disease.

Talazoparib with enzalutamide

This study is evaluating whether a drug called talazoparib may help men with prostate cancer.

The purpose of this study is to test the safety and efficacy of study drug LY3526318 in participants with diabetic peripheral neuropathic pain (DPNP). This trial is part of the chronic pain master protocol (H0P-MC-CPMP) which is a protocol to accelerate the development of new treatments fo…

MDNA11 in combination with checkpoint inhibitor

This is a Phase 1/2, multi-center, open-label, dose-escalation and expansion study to evaluate safety and tolerability, PK, pharmacodynamic, and early signal of anti-tumor activity of MDNA11 alone or in combination with a checkpoint inhibitor in patients with advanced solid tumors.

This study is evaluating whether a drug may help treat diabetic peripheral neuropathic pain.

This randomized trial will evaluate the effect of fenofibrate compared with placebo for prevention of diabetic retinopathy (DR) worsening through 4 years of follow-up in eyes with mild to moderately severe non-proliferative DR (NPDR) and no CI-DME at baseline. In addition to evaluating ef…

TTX-080-01 is a Phase 1, open label, dose escalation and dose expansion clinical study to determine the safety, tolerability, and recommended Phase 2 dose of TTX-080 monotherapy (HLA-G inhibitor) and in combination with either pembrolizumab (PD-1 inhibitor) or cetuximab (EGFR inhibitor) in…

This study is evaluating whether a combination of two drugs may help patients with multiple myeloma.

This study is evaluating whether a suspension of intestinal microbes may help treat recurrent Clostridium difficile infection.

This study is evaluating whether a drug called MF101 can reduce hot flushes in postmenopausal women.

GSK3511294 (Depemokimab)

This study is evaluating whether switching participants who have benefitted from mepolizumab or benralizumab to GSK3511294 is non-inferior to maintaining current

This study is evaluating whether a drug may help reduce the symptoms of chronic graft versus host disease.

This study is evaluating whether a medication may help improve depressive symptoms in individuals with major depressive disorder and insomnia.

Drug studies often look at the effect one or two drugs have on a medical condition, and involve one company. There is currently an urgent need for one study to efficiently test multiple drugs from more than one company, in people who have tested positive for COVID-19 but who do not current…

This study is evaluating whether a drug may help treat Nonalcoholic Steatohepatitis (NASH).

MT-5111 (experimental study drug)

This study is evaluating whether a new drug may help treat cancer.

Doxorubicin Hydrochloride

This phase III trial studies whether inotuzumab ozogamicin added to post-induction chemotherapy for patients with High-Risk B-cell Acute Lymphoblastic Leukemia (B-ALL) improves outcomes. This trial also studies the outcomes of patients with mixed phenotype acute leukemia (MPAL), and B-lymp…

This study is evaluating whether a drug may help treat Crohn's disease.

This study is evaluating whether a combination of two drugs may help treat triple negative breast cancer.

This study is evaluating whether trametinib may help treat juvenile myelomonocytic leukemia.

Treprostinil Palmitil

The main objective of the study is to assess the effect of treprostinil palmitil inhalation powder (TPIP) compared with placebo on pulmonary vascular resistance.

This study is evaluating whether a drug can improve the health of people with SSc.

This study is evaluating whether a drug may help preserve beta-cell function and delay the progression of type 1 diabetes.

This study is evaluating whether a drug may help treat Alzheimer's disease.

This study is evaluating whether a drug may help treat ulcerative colitis.

This study is evaluating whether a drug may help reduce symptoms of lupus.

This study is evaluating whether a drug may help improve breathing in premature infants.

This study is evaluating whether a drug may help treat ulcerative colitis.

The objectives of Sub-Study 1 are to evaluate the efficacy, safety, and pharmacokinetics of risankizumab as induction treatment in subjects with moderately to severely active ulcerative colitis (UC), and to identify the appropriate induction dose of risankizumab for further evaluation in S…

Relugolix Combination Therapy

This study is evaluating whether a combination of two drugs may help prevent pregnancy.

Study CC-93538-EE-001 is a Phase 3, multicenter, multinational, randomized, double-blind, placebo-controlled induction and maintenance study to evaluate the efficacy and safety of CC- 93538 in adult and adolescent participants with eosinophilic esophagitis (EoE). The study will incorporate…

Total Mesorectal Excision

This study is evaluating whether a combination of radiation therapy and immunotherapy may be more effective than radiation therapy alone in treating patients with rectal cancer that has spread to other places in the body (advanced).

This clinical trial is evaluating a drug called ART0380 in participants with advanced or metastatic solid tumors. The main goals of this study are to: Find the recommended dose of ART0380 that can be given safely to participants alone and in combination with gemcitabine or irinotecan Lear…

This study is evaluating whether a vaginal gel may help prevent the sexual transmission of certain sexually transmitted infections.

This study is evaluating whether a drug called DFMO may help treat neuroblastoma.

This study is evaluating whether a drug may help treat Crohn's disease.

This study is evaluating whether a device which delivers electric fields to the brain may help treat brain tumors.

This study is evaluating whether genetic testing may help determine the best treatment for patients with lung cancer.

pepinemab + pembrolizumab

This study is evaluating whether a combination of two drugs may help treat head and neck cancer.

Difluoromethylornithine

This study is evaluating whether a medication may help treat medulloblastoma.

This study is evaluating whether a combination of two drugs may help treat melanoma.

SPARK Symptom Screening Linked to Feedback to Providers

This study is evaluating whether a tool that helps children with cancer communicate their symptoms and a tool that helps healthcare providers manage symptoms can improve the lives of children with cancer.

Cytoreductive Nephrectomy

This study is evaluating whether the addition of surgery to a drug combination may help treat kidney cancer.

This study is evaluating whether a drug may help treat breast cancer.

CLE-100

Middleburg Heights, OH

Middleburg Heights, OH

18+

All Sexes

This study is evaluating whether a drug may help treat depression.

Edwards PASCAL System

This study is evaluating whether a new device may help repair a heart valve.

Larotrectinib Sulfate

This study is evaluating whether a drug called larotrectinib may help treat children with cancer.

Doxercalciferol (GZ427397)

Primary Objective: Evaluate the effect of Hectorol® capsules in reducing elevated levels of intact parathyroid hormone (iPTH). Secondary Objectives: Evaluate the safety profile of Hectorol® capsules versus Rocaltrol® (calcitriol) capsules. Determine the pharmacokinetic profile of 1,25-d…

GNX oral suspension, TID

This is a Phase 3, global, double-blind, randomized, placebo-controlled study of adjunctive GNX treatment in children and adults with TSC-related epilepsy. The study consists of a 4-week prospective baseline phase, defined as the first 28 days following screening, followed by a double-blin…

This study is evaluating whether a new medicine can control blood sugar levels in people with type 2 diabetes.

This study is evaluating whether Adhansia XR is safe for children.

M6-C Artificial Cervical Disc

This study is evaluating whether a new artificial disc is as effective as a standard surgery.

This study is evaluating whether a drug may help treat colorectal cancer.

This study is evaluating whether a drug called abemaciclib may help treat breast cancer.

Trastuzumab deruxtecan

This study is evaluating whether a combination of two drugs may help treat lung cancer.

This study is evaluating whether olaparib may help treat children with cancer.

This study is evaluating whether a device which delivers electrical nerve block may help reduce pain in individuals who have had an amputation.

This is an open-label, monotherapy study of pemigatinib in participants with recurrent glioblatoma (GBM) or other primary CNS tumors with an activating FGFR1-3 mutation or fusion/rearrangement. This study consists of 3 cohorts, Cohorts A, B, and C, and will enroll approximately 82, 82, and…

Stromal Vascular Fraction Cells

The investigator's goal is to determine the effectiveness of stromal vascular fraction (SVF) cell injection to treat small rotator cuff tears without surgery.

Primary Objective: -To determine the antitumor activity of SAR444245 in combination with cemiplimab. Secondary Objectives: To determine the recommended phase 2 dose and to assess the safety profile of SAR444245 when combined with cemiplimab To assess other indicators of antitumor activi…

This study is evaluating whether a drug may help reduce the time it takes for food to move through the digestive tract.

This study is evaluating whether a drug which combines two medications may help treat breast cancer.

BGF MDI 320/28.8/9.6 μg

This study is evaluating whether a new combination of medications may help treat severe asthma.

This study is evaluating whether a drug may help treat Crohn's disease.

Eflornithine Hydrochloride

This study is evaluating whether a combination of chemotherapy, immunotherapy, and eflornithine might be more effective than chemotherapy alone in treating patients with relapsed or refractory neuroblastoma.

This phase II trial studies nivolumab and ipilimumab in treating patients with rare tumors. Immunotherapy with monoclonal antibodies, such as nivolumab and ipilimumab, may help the body's immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread.…

This study is evaluating whether a combination of chemotherapy and radiation therapy is more effective than chemotherapy alone in treating Ewing's sarcoma.

This study is evaluating whether a combination of two drugs may help treat cancer.

A 2-year phase 3, multicentre, randomised, parallel-group, sham-controlled, double-masked study. Primary efficacy will be determined at Week 52.

This study is evaluating whether a combination of two drugs may help treat cancer.

This study is evaluating whether a combination of two drugs may help treat ovarian cancer.

This study is evaluating whether a combination of two drugs may be more effective than one drug alone in treating low-grade glioma.