This trial tests the effects of a drug (AZD4041) on respiratory drive when combined with morphine in healthy recreational opioid users. 44 participants will be randomly assigned to either the drug or placebo. Total study duration: 54 days.
- Opioid Use Disorder
2 Primary · 49 Secondary · Reporting Duration: 54 days
Side Effects for
2 Treatment Groups
AZD4041 and morphine
1 of 2
Placebo and morphine
1 of 2
44 Total Participants · 2 Treatment Groups
Primary Treatment: AZD4041 and morphine · Has Placebo Group · Phase 1
Participation is compensated
You will be compensated for participating in this trial.
Who is running the clinical trial?
Age 18 - 55 · All Participants · 10 Total Inclusion CriteriaMark “Yes” if the following statements are true for you:
Frequently Asked Questions
What are the proposed objectives of this clinical investigation?
"This 54 day clinical trial will primarily measure the incidence of increased end tidal carbon dioxide (EtCO2). Additionally, it shall also assess Time of last measurable observed concentration of morphine and its metabolites (Tlast), Time to reach maximum (peak) plasma concentration of morphine and its metabolites (Tmax), as well as Predose concentration of AZD4041 observed immediately prior to the next successive dose (Ctrough)." - Anonymous Online Contributor
To which demographic is participation in this trial accessible?
"This clinical trial is actively recruiting 36 individuals aged 18 to 55 with a history of recreational opioid use. To be eligible, patients must satisfy the criteria as outlined in DSM-5 for substance abuse disorder, provide signed informed consent prior to initiation of any protocol specific procedures and maintain availability throughout the course of study. Furthermore, BMI should fall between 18 kg/m2 and 35 kg/m2 with body weight exceeding 50kg at Screening; FSH levels ≥ 40 mIU/mL at Screening or have had hysterectomy, bilateral oophorectomy and/or bilateral salpingectomy or bilateral tubal ligation" - Anonymous Online Contributor
What potential dangers do AZD4041 and morphine pose to individuals receiving treatment?
"We have assigned a score of 1 to AZD4041 and morphine due to our team's assessment that there is only minimal data supporting their safety and efficacy." - Anonymous Online Contributor
Does this medical research currently have openings for volunteers?
"Affirmative. As reported on clinicaltrials.gov, this research is actively searching for volunteers who meet its criteria. First posted in September of 2022 and recently updated in November, it's looking to enrol 36 individuals from a single site." - Anonymous Online Contributor
Does the research protocol admit individuals over 40 years of age?
"The entrance requirements of this clinical trial state that participants must be between 18 to 55 years old. In comparison, there are 22 trials specifically for minors and 240 studies targeting seniors." - Anonymous Online Contributor
How many individuals are involved in this experiment?
"Affirmative. Clinicaltrials.gov records suggest that this research project, which was originally posted on September 20th 2022, is currently recruiting test subjects. The study needs 36 volunteers from 1 medical centre to complete it's objectives." - Anonymous Online Contributor