Low-Dose vs High-Dose Epidural Morphine for Post-Cesarean Pain Management
AO
BC
Overseen ByBrian Casey, MD
Age: Any Age
Sex: Female
Trial Phase: Phase < 1
Sponsor: University of Alabama at Birmingham
No Placebo GroupAll trial participants will receive the active study treatment (no placebo)
Trial Summary
What is the purpose of this trial?
The purpose of this study is to compare 50mcg to 150mcg morphine in epidural for the goal of decreasing side effects of medication with lower dose in patients who receive a QL block
Research Team
AS
Ayodeji Sanusi, MD
Principal Investigator
University of Alabama at Birmingham
Eligibility Criteria
This trial is for women scheduled for cesarean delivery who want a QL block. It's not open to those with insulin-treated diabetes, placental abnormalities, preeclampsia, or a history of opioid use disorder.Inclusion Criteria
All women presenting for scheduled cesarean delivery who desire a QL block
Exclusion Criteria
Women who have had a pregnancy with preeclampsia complications.
Women who are pregnant and need insulin to control their diabetes are not eligible.
Women who have pregnancy problems related to the placenta are not eligible.
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Timeline
Screening
Participants are screened for eligibility to participate in the trial
1-2 weeks
Treatment
Participants receive either 50mcg or 150mcg of morphine in their neuraxial block during cesarean delivery
During hospital stay (up to 2 days)
In-hospital stay
Follow-up
Participants are monitored for side effects such as nausea, urinary retention, and pruritus, as well as neonatal outcomes
2 days following cesarean delivery
In-hospital assessments
Treatment Details
Interventions
- Morphine Sulfate 150mcg
- Morphine Sulfate 50mcg
Trial Overview The study compares two doses of morphine sulfate (50mcg and 150mcg) given epidurally to see if the lower dose can reduce side effects while still providing pain relief after cesarean delivery.
Participant Groups
2Treatment groups
Experimental Treatment
Active Control
Group I: Group B: 50 mcg morphineExperimental Treatment1 Intervention
Patients in this group will receive 50mcg of morphine in their neuraxial block
Group II: Group A: 150 mcg morphineActive Control1 Intervention
Patients in this group will receive 150mcg of morphine in their neuraxial block
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Who Is Running the Clinical Trial?
University of Alabama at Birmingham
Lead Sponsor
Trials
1,677
Recruited
2,458,000+
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