Vancomycin for Fractures

Phase-Based Progress Estimates
University Hospital, San Antonio, TXFracturesVancomycin - Drug
18 - 89
All Sexes
What conditions do you have?

Study Summary

This trial found that vancomycin powder reduces infection-related complications when applied to open fractures in the emergency department.

Eligible Conditions
  • Open Fractures

Treatment Effectiveness

Effectiveness Progress

3 of 3
This is further along than 93% of similar trials

Study Objectives

1 Primary · 4 Secondary · Reporting Duration: Within one year of injury date

Within one year of injury date
Death rate
Deep-space infection rate at prophylaxis site
Readmission rate for open fracture infection
Superficial infection rate requiring post-operative medical intervention
Unplanned repeat visit rate

Trial Safety

Safety Progress

3 of 3
This is further along than 85% of similar trials

Trial Design

3 Treatment Groups

Observational Arm
1 of 3
Control Arm
1 of 3
Intervention Arm
1 of 3

Active Control

Experimental Treatment

200 Total Participants · 3 Treatment Groups

Primary Treatment: Vancomycin · No Placebo Group · Phase 4

Intervention Arm
Experimental Group · 1 Intervention: Vancomycin · Intervention Types: Drug
Observational ArmNoIntervention Group · 1 Intervention: Observational Arm · Intervention Types:
Control ArmNoIntervention Group · 1 Intervention: Control Arm · Intervention Types:
First Studied
Drug Approval Stage
How many patients have taken this drug
FDA approved

Trial Logistics

Trial Timeline

Screening: ~3 weeks
Treatment: Varies
Reporting: within one year of injury date

Who is running the clinical trial?

San Antonio Military Medical CenterFED
21 Previous Clinical Trials
4,639 Total Patients Enrolled
United States Army Institute of Surgical ResearchFED
29 Previous Clinical Trials
1,568 Total Patients Enrolled
The University of Texas Health Science Center at San AntonioLead Sponsor
402 Previous Clinical Trials
73,783 Total Patients Enrolled
Robert A De Lorenzo, MDPrincipal InvestigatorUniversity of Texas
2 Previous Clinical Trials
916 Total Patients Enrolled

Eligibility Criteria

Age 18 - 89 · All Participants · 4 Total Inclusion Criteria

Mark “Yes” if the following statements are true for you:
You have a broken bone that is sticking out of your skin.

Frequently Asked Questions

In what situations is Vancomycin typically prescribed?

"Vancomycin is an antibiotic effective at treating afflictions caused by staphylococcal infections, such as enterocolitis due to Staphylococcus aureus." - Anonymous Online Contributor

Unverified Answer

How many participants are currently taking part in this clinical research?

"Confirmed. The database affirms that this medical research endeavor, which was first posted on October 5th 2020, is actively recruiting for participants. Approximately 200 patients need to be recruited from two different locations." - Anonymous Online Contributor

Unverified Answer

What risks should be taken into account when utilizing Vancomycin?

"Taking into consideration that it is a Phase 4 study, the safety of Vancomycin was rated 3 out of 3 by Power's team due to its approval for clinical use." - Anonymous Online Contributor

Unverified Answer

Is it feasible to become a participant in this research?

"In search of 200 participants, this trial invites those 18 or older and with a fracture to their humerus, radius, ulna, femur, tibia and/or fibula. Notably, eligible individuals must be within 24 hours from the time of injury for study intervention." - Anonymous Online Contributor

Unverified Answer

Is the enrollment for this clinical experiment open to those aged 45 or older?

"This research experiment has a strict age requirement, with suitable candidates needing to be between 18 and 89 years old. There are 50 studies available for minors while 213 trials exist specifically designed for individuals over the age of 65." - Anonymous Online Contributor

Unverified Answer

Has any prior research been conducted involving Vancomycin?

"At present, 55 clinical trials are being carried out to research Vancomycin. 6 of those studies have reached Phase 3 while most of the rest are located in Jupiter, Florida. In total, 315 medical sites around the world are conducting trials for this drug." - Anonymous Online Contributor

Unverified Answer

Does this trial presently accept participants?

"According to information published on, this medical trial is presently enrolling patients. It was first posted in October 5th 2020 and the details were most recently revised on February 28th 2022." - Anonymous Online Contributor

Unverified Answer
Please Note: These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.