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Morphine for Colorectal Surgery

Phase 4
Waitlist Available
Led By Adam W Amundson, MD
Research Sponsored by Mayo Clinic
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 24 hours after it drug administration
Awards & highlights

Study Summary

This trial is testing different doses of spinal morphine and hydromorphone to find the best dose for people undergoing minimally-invasive colorectal surgery.

Eligible Conditions
  • Colorectal Surgery
  • Postoperative Pain
  • Opioid Analgesics

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~12 and 24 hours after it drug administration
This trial's timeline: 3 weeks for screening, Varies for treatment, and 12 and 24 hours after it drug administration for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Secondary outcome measures
Overall Benefits of Analgesia Score (OBAS)
Postoperative Pain Control
Presence and Severity of Opioid-related Side Effects at Their Highest Doses
+1 more

Trial Design

2Treatment groups
Experimental Treatment
Group I: MorphineExperimental Treatment1 Intervention
Subjected to sequential up and down dose titration using biased coin method in parallel with the hydromorphone arm
Group II: HydromorphoneExperimental Treatment1 Intervention
Subjected to sequential up and down dose titration using biased coin method in parallel with the morphine arm
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Morphine
2013
Completed Phase 4
~2230
Hydromorphone
2005
Completed Phase 4
~4340

Find a Location

Who is running the clinical trial?

Mayo ClinicLead Sponsor
3,205 Previous Clinical Trials
3,766,704 Total Patients Enrolled
Adam W Amundson, MDPrincipal InvestigatorMayo Clinic

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Are there any potential risks associated with Morphine usage?

"Due to its Phase 4 status, Morphine is officially approved and thus receives a safety rating of 3."

Answered by AI

What other experiments have tested the efficacy of Morphine?

"Currently, 63 clinical trials examining Morphine are underway. Of these studies, 16 have reached Phase 3 status and the majority of them take place in Salt Lake City, Utah across 146 different sites."

Answered by AI

Does this trial allow for minors to participate?

"This trial only permits adults aged 18 and up with a maximum age of 75 to participate."

Answered by AI

To what extent is participation in this medical experiment being limited?

"Indeed, the clinicaltrials.gov website establishes that this investigation is actively seeking participants. This medical trial was first published on March 10th 2021 and has been revised most recently on July 19th 2022. The research aims to recruit 85 people from a single location."

Answered by AI

Is enrollment for this research still open to participants?

"This research study, which was first listed on March 10th 2021, is actively recruiting participants. The trial's details have been most recently updated on July 19th 2022 according to clinicaltrials.gov."

Answered by AI

For what indications is Morphine usually prescribed?

"Morphine can be utilised to combat a range of medical symptoms, including coughing, certain procedures that involve discomfort and pain."

Answered by AI

Who meets the criteria to partake in this experiment?

"This medical experiment is accepting applications from subjects with postoperative pain and aged between 18 to 75. At present, 85 people are needed for the trial."

Answered by AI
Recent research and studies
clinicaltrials.govStudy
Intrathecal Opioids for Colorectal Resection
Adam Amundson MD 2021. "Intrathecal Opioids for Colorectal Resection". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT04752033.
~20 spots leftby Apr 2025
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