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Behavioural Intervention
Resistance Exercise Training for Aging
N/A
Recruiting
Led By Mark S Miller, PhD
Research Sponsored by University of Massachusetts, Amherst
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial Must have
Older adult volunteers aged 65-75 years old who are healthy and sedentary (defined as no formal exercise program for the year prior to evaluation and < 2 sessions of volitional exercise per week)
Be older than 65 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up this measure will be collected for each volunteer pre- and post-16 week exercise intervention and take approximately 30 minutes to collect for each time point.
Awards & highlights
Study Summary
This trial is designed to study the effects of two different types of exercise training on muscle function in older men and women. The goal is to see if one type of exercise is better than the other for improving muscle function.
Who is the study for?
This trial is for healthy, sedentary older adults aged 65-75 who can walk without aid and live independently. They must not have exercised regularly in the past year, be non-smokers for at least a year, and women should be postmenopausal. Participants cannot join if they're on certain medications like anti-coagulants or hormone replacement therapy, have severe health conditions affecting physical function or muscle performance, uncontrolled high blood pressure, a BMI over 30 or under 18, or any contraindications to MRI.Check my eligibility
What is being tested?
The study tests how older men and women respond differently to two types of exercise training: low-velocity resistance training (traditional weight lifting) versus high-velocity power training (fast movements). Each participant will train one leg with each method for 16 weeks to compare molecular and cellular changes as well as overall muscle function improvements between sexes.See study design
What are the potential side effects?
Since this trial involves regular exercise programs designed for seniors, potential side effects may include typical exercise-related discomforts such as muscle soreness or fatigue. However, due to careful screening and physician oversight required before participation, significant risks are minimized.
Eligibility Criteria
Inclusion Criteria
You may be eligible if you check “Yes” for the criteria belowSelect...
I am between 65-75 years old, healthy, and have not regularly exercised in the past year.
Timeline
Screening ~ 3 weeks3 visits
Treatment ~ Varies
Follow Up ~ this measure will be collected for each volunteer pre- and post-16 week exercise intervention and take approximately 30 minutes to collect for each time point.
Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~this measure will be collected for each volunteer pre- and post-16 week exercise intervention and take approximately 30 minutes to collect for each time point.
Treatment Details
Study Objectives
Outcome measures can provide a clearer picture of what you can expect from a treatment.Primary outcome measures
Change in myosin attachment time
Change in peak isokinetic power
Change in single fiber specific power
Side effects data
From 2015 Phase 3 trial • 50 Patients • NCT0218884918%
Pain
14%
Falls
14%
Gastroinftestinal symptoms
5%
Fever
100%
80%
60%
40%
20%
0%
Study treatment Arm
Placebo
Creatine
Trial Design
1Treatment groups
Experimental Treatment
Group I: TrainingExperimental Treatment1 Intervention
All participants will participate in the 16-week resistance exercise training program.
Find a Location
Who is running the clinical trial?
University of Massachusetts, AmherstLead Sponsor
78 Previous Clinical Trials
467,722 Total Patients Enrolled
1 Trials studying Aging
260 Patients Enrolled for Aging
National Institutes of Health (NIH)NIH
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7,506,800 Total Patients Enrolled
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3,883 Patients Enrolled for Aging
National Institute on Aging (NIA)NIH
1,675 Previous Clinical Trials
28,020,835 Total Patients Enrolled
161 Trials studying Aging
76,007 Patients Enrolled for Aging
Media Library
Eligibility Criteria:
This trial includes the following eligibility criteria:- I am not postmenopausal or on hormone therapy in the last 5 years.I have a history of heart problems or procedures.My BMI is either above 30 or below 18.I have not had severe lung disease, rheumatoid arthritis, uncontrolled high blood pressure, smoked in the last year, or had bad leg joint pain.I experience symptoms like pain, cramps, or breathlessness with activity.I am on blood thinners or have a blood clotting disorder.I am between 65-75 years old, healthy, and have not regularly exercised in the past year.I can walk without help, live on my own, and have my doctor's approval to join the study.I have lost more than 2.5 kg without trying in the last 3 months.I have a major neurological or muscle condition affecting my movement.I am not on medications that could weaken my physical ability.
Research Study Groups:
This trial has the following groups:- Group 1: Training
Awards:
This trial has 1 awards, including:- No Placebo-Only Group - All patients enrolled in this study will receive some form of active treatment.
Timeline:
This trial has the following timeline:- Screening: It may take up to 3 Weeks to process to see if you qualify in this trial.
- Treatment: The duration you will receive the treatment varies.
- Follow Ups: You may be asked to continue sharing information regarding the trial for 6 Months after you stop receiving the treatment.
Frequently Asked Questions
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
Does the research have an upper-age limit for participants?
"This research seeks to include elderly persons aged between 65 and 75."
Answered by AI
Is it possible to participate in the clinical experiment?
"Prospective participants for this trial must be within the age range of 65 and 75, suffering from biological aging. This experiment is currently seeking to enroll 50 individuals in total."
Answered by AI
What is the current participant capacity for this research endeavor?
"Affirmative. Clinicaltrials.gov explicitly states that this investigation, which was first posted on 1st of January in 2018, is currently recruiting participants. The research requires 50 patients from a single medical center to join the study."
Answered by AI
Are recruitment efforts for this clinical trial still underway?
"This clinical trial is actively seeking the inclusion of participants, as indicated by its listing on clinicaltrials.gov. It was first made available to potential enrollees in January 2018 and has since been regularly updated up until June 2020."
Answered by AI
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