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Exercise for Improved Cellular Metabolism in Physical Activity (MoTrMyo Trial)
N/A
Recruiting
Led By Lauren Sparks, PhD
Research Sponsored by Translational Research Institute for Metabolism and Diabetes, Florida
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up week 12 visit
Awards & highlights
MoTrMyo Trial Summary
This trial will study how well different types of exercise can change the way our cells handle fat and sugar, which could lead to better health and fitness.
Who is the study for?
This trial is for adults over 18 years old with a BMI between 19 and 35 kg/m2. It includes both highly active individuals who exercise regularly (either endurance or resistance training) and sedentary participants who do minimal structured exercise. Participants must be willing to provide informed consent, undergo an extra muscle biopsy, speak English well enough to understand instructions, and not use performance-enhancing drugs in the last six months.Check my eligibility
What is being tested?
The study investigates how different types of exercise (resistance or aerobic) can cause long-term changes in skeletal muscle cells that may improve metabolic health through epigenetic regulation. It involves collecting additional muscle biopsies from participants which will contribute to the MoTrPAC repository for future research.See study design
What are the potential side effects?
There are no direct side effects mentioned as this is an observational study involving physical activity interventions rather than drug treatments. However, typical risks associated with taking a muscle biopsy include pain at the biopsy site, bruising, infection risk at the needle insertion point.
MoTrMyo Trial Timeline
Screening ~ 3 weeks3 visits
Treatment ~ Varies
Follow Up ~ week 12 visit
Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~week 12 visit
Treatment Details
Study Objectives
Outcome measures can provide a clearer picture of what you can expect from a treatment.Primary outcome measures
Insulin-stimulated glycogen synthesis in human skeletal muscle cell cultures (HSkMC)
Mitochondrial function
MoTrMyo Trial Design
3Treatment groups
Active Control
Group I: Sedentary exercise groupActive Control1 Intervention
Group II: Athletic groupActive Control1 Intervention
Group III: Sedentary no-exercise groupActive Control1 Intervention
Find a Location
Who is running the clinical trial?
Translational Research Institute for Metabolism and Diabetes, FloridaLead Sponsor
40 Previous Clinical Trials
3,197 Total Patients Enrolled
Wake Forest UniversityOTHER
190 Previous Clinical Trials
164,200 Total Patients Enrolled
AdventHealth Translational Research InstituteLead Sponsor
48 Previous Clinical Trials
19,781 Total Patients Enrolled
Media Library
Eligibility Criteria:
This trial includes the following eligibility criteria:- I am 18 years old or older.I am willing to have an extra needle insertion for muscle tissue collection.I haven't used estrogens or progestins in the last 6 months, except for birth control or menopause symptoms.My blood pressure is higher than normal for my age.I am unable to understand and agree to the study's requirements.My kidneys are not working well (low filtration rate).I have diabetes or high blood sugar, or I'm taking medication that affects my blood sugar.I am on long-term antibiotics or antivirals, or I have HIV.I have been diagnosed with COPD.I have a history of bleeding disorders or clotting issues.I haven't received treatment for an autoimmune disorder in the last 6 months.My thyroid is underactive or within normal limits, but not overactive.My weight has changed by more than 5% in the last 6 months.I have a history of fractures without injury or am being treated for low bone mass/osteoporosis.I have a significant heart condition.I haven't had cancer treatment (except for skin cancer) in the last 2 years or hormone therapy in the last 6 months.I am over 18, speak English, have a BMI between 19 and 35, and exercise regularly.People who walk for fun can join the study, but not if they experience high heart rate, difficulty breathing, or excessive sweating during the activity.Your body mass index (BMI) must be between 19 and 35 kg/m2.If you bike to work or use a bicycle as your main mode of transportation for more than one day per week, you are not considered a sedentary person.I am an adult who does not exercise regularly.
Research Study Groups:
This trial has the following groups:- Group 1: Sedentary exercise group
- Group 2: Athletic group
- Group 3: Sedentary no-exercise group
Awards:
This trial has 1 awards, including:- No Placebo-Only Group - All patients enrolled in this study will receive some form of active treatment.
Timeline:
This trial has the following timeline:- Screening: It may take up to 3 Weeks to process to see if you qualify in this trial.
- Treatment: The duration you will receive the treatment varies.
- Follow Ups: You may be asked to continue sharing information regarding the trial for 6 Months after you stop receiving the treatment.
Physical Activity Patient Testimony for trial: Trial Name: NCT04334343 — N/A
Frequently Asked Questions
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
How many test subjects are allowed in this research project?
"Yes, the latest information on clinicaltrials.gov states that this research is actively recruiting patients. This study was first advertised on November 1st 2020 and was updated most recently on April 12th 2022. 400 individuals are needed from a single research site."
Answered by AI
Who else is applying?
What state do they live in?
Florida
What site did they apply to?
AdventHealth Translational Research Institute
What portion of applicants met pre-screening criteria?
Met criteria
How many prior treatments have patients received?
0
Why did patients apply to this trial?
I want to learn more not only for myself but to help others as well.
PatientReceived no prior treatments
What questions have other patients asked about this trial?
To get a biopsy of the muscle is the area numbed first~?
PatientReceived no prior treatments
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