Exercise for Improved Cellular Metabolism in Physical Activity
(MoTrMyo Trial)
What You Need to Know Before You Apply
What is the purpose of this trial?
The goal of the study is to examine the ability of resistance or aerobic exercise training to "imprint" skeletal muscle cells in a manner which confers long-term changes in this tissue which in-turn contribute to improved metabolic health and functional capacity through epigenetic regulation of novel exercise response genes. This study will also provide primary human skeletal muscle cells to the Molecular Transducers of Physical Activity Consortium (MoTrPAC) (NCT03960827) repository for future use.
Who Is on the Research Team?
Lauren Sparks, PhD
Principal Investigator
Study Principal Investigator
Are You a Good Fit for This Trial?
This trial is for adults over 18 years old with a BMI between 19 and 35 kg/m2. It includes both highly active individuals who exercise regularly (either endurance or resistance training) and sedentary participants who do minimal structured exercise. Participants must be willing to provide informed consent, undergo an extra muscle biopsy, speak English well enough to understand instructions, and not use performance-enhancing drugs in the last six months.Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants undergo aerobic or resistance exercise training to study its effects on skeletal muscle metabolism
Follow-up
Participants are monitored for safety and effectiveness after treatment
What Are the Treatments Tested in This Trial?
Interventions
- Muscle Biopsy Collection
- Resistance and Aerobic Exercise Training
Find a Clinic Near You
Who Is Running the Clinical Trial?
Translational Research Institute for Metabolism and Diabetes, Florida
Lead Sponsor
AdventHealth Translational Research Institute
Lead Sponsor
Wake Forest University
Collaborator