Exercise for Improved Cellular Metabolism in Physical Activity

(MoTrMyo Trial)

Overseen By Recruitment Department

Age: 18+

Sex: Any

Trial Phase: Academic

Sponsor: Translational Research Institute for Metabolism and Diabetes, Florida

No Placebo Group All trial participants will receive the active study treatment (no placebo)

Compensation: Varies

Number of Visits: Unknown

Duration: 12 weeks

400 Participants Needed

Trial Summary

What is the purpose of this trial?

The goal of the study is to examine the ability of resistance or aerobic exercise training to "imprint" skeletal muscle cells in a manner which confers long-term changes in this tissue which in-turn contribute to improved metabolic health and functional capacity through epigenetic regulation of novel exercise response genes. This study will also provide primary human skeletal muscle cells to the Molecular Transducers of Physical Activity Consortium (MoTrPAC) (NCT03960827) repository for future use.

Research Team

Lauren Sparks, PhD

Principal Investigator

Study Principal Investigator

Eligibility Criteria

This trial is for adults over 18 years old with a BMI between 19 and 35 kg/m2. It includes both highly active individuals who exercise regularly (either endurance or resistance training) and sedentary participants who do minimal structured exercise. Participants must be willing to provide informed consent, undergo an extra muscle biopsy, speak English well enough to understand instructions, and not use performance-enhancing drugs in the last six months.

Inclusion Criteria

ADULT PARTICIPANT INCLUSION CRITERIA - SEDENTARY PARTICIPANTS: Willingness to provide informed consent to participate in the MoTrPAC Study, willingness to undergo an extra needle insertion for the extra muscle tissue collection during the MoTrPAC muscle biopsy, must be able to read and speak English well enough to provide informed consent and understand instructions, aged ≥18 y, BMI >19 to <35 kg/m2, sedentary defined as self-reporting no more than 1 day per week, lasting no more than 60 minutes, of regular (structured) EE or RE in the past year

I am over 18, speak English, have a BMI between 19 and 35, and exercise regularly.

Exclusion Criteria

I haven't used estrogens or progestins in the last 6 months, except for birth control or menopause symptoms.

My blood pressure is higher than normal for my age.

Psychiatric illness: Hospitalization for any psychiatric condition within one year, Center for Epidemiological Studies-Depression Scale (CESD) score ≥16

Timeline

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks

Treatment

Participants undergo aerobic or resistance exercise training to study its effects on skeletal muscle metabolism

12 weeks

Regular visits for exercise sessions

Follow-up

Participants are monitored for safety and effectiveness after treatment

4 weeks

Treatment Details

Interventions

• Muscle Biopsy Collection
• Resistance and Aerobic Exercise Training

Trial Overview The study investigates how different types of exercise (resistance or aerobic) can cause long-term changes in skeletal muscle cells that may improve metabolic health through epigenetic regulation. It involves collecting additional muscle biopsies from participants which will contribute to the MoTrPAC repository for future research.

Participant Groups

Group I: Sedentary exercise group Active Control 1 Intervention

Group II: Athletic group Active Control 1 Intervention

Group III: Sedentary no-exercise group Active Control 1 Intervention

Who Is Running the Clinical Trial?

Translational Research Institute for Metabolism and Diabetes, Florida

Lead Sponsor

Trials

41

Recruited

3,600+

AdventHealth Translational Research Institute

Lead Sponsor

Trials

51

Recruited

5,900+

Wake Forest University

Collaborator

Trials

193

Recruited

151,000+