Environmental Enrichment for Alcoholism
What You Need to Know Before You Apply
What is the purpose of this trial?
This trial explores how different activities and environments might affect drinking behaviors and mental health in individuals with alcohol use disorder (AUD). Participants will engage in activities such as virtual reality, games, puzzles, and crafts, or watch videos, to assess the impact on their alcohol craving and consumption. Known as Environmental Enrichment, this approach suits individuals diagnosed with AUD who consume more than 7 drinks per week for women or 14 drinks per week for men and are open to trying novel activities as part of their treatment. The study takes place in Baltimore and involves multiple visits to evaluate these effects. As a Phase 1 trial, the research focuses on understanding how the treatment works in people, offering participants the opportunity to be among the first to experience this innovative approach.
Will I have to stop taking my current medications?
The trial does not specify if you need to stop taking your current medications, but you cannot participate if you are currently using FDA-approved medications for alcohol use disorder (AUD) or seeking treatment for AUD.
What prior data suggests that this protocol is safe for people with alcohol use disorder?
Earlier studies have shown that creating a stimulating environment can reduce relapse rates in people dealing with addiction. This approach, known as environmental enrichment, involves providing individuals with a variety of engaging activities. Research shows that this method is well-received and improves outcomes for those with substance use issues.
Animal studies suggested that a lively, engaging environment can help prevent addictive behaviors. These studies found no major safety concerns or negative effects, indicating that environmental enrichment is generally safe for humans.
Since this study is in its early stages, the main goal is to ensure the treatment's safety. This phase involves closely monitoring participants to confirm the approach is safe and well-tolerated. Prospective participants should know that this treatment aims to provide a non-medical way to improve mental health and reduce alcohol cravings.12345Why are researchers excited about this trial?
Unlike traditional treatments for alcohol use disorder that often involve medication or behavioral therapy, Environmental Enrichment focuses on altering the living environment to encourage healthier habits and reduce substance use. This innovative approach aims to stimulate the brain with engaging activities, social interactions, and sensory experiences, potentially leading to more sustainable recovery outcomes. Researchers are excited about this method because it addresses lifestyle factors and could complement existing therapies, offering a holistic way to support individuals in overcoming alcoholism.
What evidence suggests that environmental enrichment might be an effective treatment for alcohol use disorder?
Research has shown that creating a stimulating environment can be a promising way to treat alcohol use disorder (AUD). Studies have found that it might help reduce the desire to drink by offering enjoyable activities as alternatives. In animal studies, these enriched environments led to less drinking and fewer relapses. This trial will explore the effects of environmental enrichment on participants with alcohol use disorder. This method may work by changing how the brain reacts to alcohol triggers, making other activities more appealing. Early evidence suggests that activities like games, crafts, and virtual reality can help shift attention away from drinking.678910
Who Is on the Research Team?
Lorenzo Leggio, M.D.
Principal Investigator
National Institute on Drug Abuse (NIDA)
Are You a Good Fit for This Trial?
This study is for adults over 21 with Alcohol Use Disorder (AUD). It's designed to see if different activities and environments can influence their drinking habits and mental health. Participants must be able to visit Baltimore up to 10 times.Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Baseline Assessment
Participants undergo a physical exam, blood and urine tests, a breath test for alcohol, and a body composition test. They answer questions about alcohol and substance use, mental and physical health, mood and anxiety, and sleep quality.
Active Stage
Participants use a virtual reality system and engage in activities like video games, puzzles, books, and crafts. Sessions last for 3 hours.
Passive Stage
Participants watch videos selected by the research team. Sessions last for 3 hours.
Follow-up
Participants are monitored for safety and effectiveness after treatment, including assessments of alcohol consumption and cue reactivity.
What Are the Treatments Tested in This Trial?
Interventions
- Environmental Enrichment
Find a Clinic Near You
Who Is Running the Clinical Trial?
National Institute on Drug Abuse (NIDA)
Lead Sponsor