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Immobilized Leg for Muscle Atrophy

N/A

Recruiting

Led By Emily E Howard, PhD

Research Sponsored by United States Army Research Institute of Environmental Medicine

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Be between 18 and 65 years old

Timeline

Screening 3 weeks

Treatment Varies

Follow Up 90 minutes

Awards & highlights

Study Summary

This trial will study how muscles respond to being immobilized and not being used. Twelve adults will have one leg immobilized with a knee brace for five days while the other leg will be used as a

Who is the study for?

This trial is for healthy adults aged 18-39, with a BMI of 18.5-30, who exercise regularly and have no chronic illnesses or musculoskeletal injuries. Participants must avoid alcohol, nicotine products, caffeine, and dietary supplements during the study. Women should have normal menstrual cycles or be on hormonal contraception.Check my eligibility

What is being tested?

The study tests how muscle responds to protein intake when one leg is immobilized versus the active other leg in adults. It involves wearing a knee brace for five days and consuming whey protein to examine molecular changes in muscle tissue through blood samples and biopsies.See study design

What are the potential side effects?

There are no specific side effects mentioned for this trial as it primarily involves immobilization of a limb and consumption of whey protein; however, potential discomfort from wearing a brace and undergoing muscle biopsies may occur.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ 90 minutes

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~90 minutes

This trial's timeline: 3 weeks for screening, Varies for treatment, and 90 minutes for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

Integrated ribonucleic acid (RNA) synthesis

Intramuscular protein signaling response to protein ingestion

Trial Design

2Treatment groups

Experimental Treatment

Group I: Non-immobilized legExperimental Treatment1 Intervention

One leg of a young, healthy adult will remain active and not immobilized for 5 days.

Group II: Immobilized LegExperimental Treatment1 Intervention

One leg of a young, healthy adult will be randomly assigned to undergo 5 days of immobilization using a rigid knee brace.

Do I qualify?Apply below to find out

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Who is running the clinical trial?

United States Army Research Institute of Environmental MedicineLead Sponsor

59 Previous Clinical Trials

3,418 Total Patients Enrolled

Emily E Howard, PhDPrincipal InvestigatorUS Army Research Institute of Environmental Medicine

1 Previous Clinical Trials

68 Total Patients Enrolled

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is the enrollment for this research study currently open and accepting participants?

"As detailed on clinicaltrials.gov, this research endeavor is actively pursuing participants. The trial's initial posting date was 2/20/2024, with the latest update recorded on 4/5/2024."

Answered by AI

How large is the participant pool for this clinical trial in its entirety?

"Affirmative. Information sourced from clinicaltrials.gov affirms that this investigation is currently seeking suitable candidates. Initially published on February 20, 2024, and most recently revised on April 5, 2024, the study aims to recruit a total of 12 participants at a single site."

Answered by AI