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Normocapnia for Cerebral Blood Flow (MEKC Trial)

N/A
Recruiting
Led By Jeremy J Walsh, PhD
Research Sponsored by McMaster University
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Between the ages of 18 and 35
Be between 18 and 65 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 90-minutes
Awards & highlights

MEKC Trial Summary

This trial aims to study the effect of a ketone supplement on blood flow in the brain. The study will investigate whether manipulating a specific measurement of carbon dioxide levels in the body after taking the supplement can

Who is the study for?
This trial is for young adults aged 18-35 with normal blood pressure who are not obese, smokers, or have respiratory illnesses. It excludes those with diabetes, cardiovascular diseases, a history of concussions with symptoms, on ketogenic diets or ketone supplements, and elite athletes.Check my eligibility
What is being tested?
The study tests the effect of a ketone monoester supplement on cerebral blood flow in two scenarios: normocapnia (keeping CO2 levels at baseline) and poikilocapnia (natural breathing without targeting CO2 levels).See study design
What are the potential side effects?
Potential side effects may include changes in blood pH and hyperventilation due to the body's response to increased ketone levels after taking the supplement.

MEKC Trial Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
Select...
I am between 18 and 35 years old.

MEKC Trial Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~90-minutes
This trial's timeline: 3 weeks for screening, Varies for treatment, and 90-minutes for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Resting cerebral blood flow (CBF)
Secondary outcome measures
Blood pH
Cerebrovascular Reactivity of the Internal Carotid and Middle Cerebral Artery as assessed by Duplex Ultrasound and Transcranial Doppler Ultrasound, respectively.
End-tidal CO2
+3 more

MEKC Trial Design

2Treatment groups
Experimental Treatment
Placebo Group
Group I: NormocapniaExperimental Treatment1 Intervention
Breathing air mixture with slightly elevated CO2 to maintain PetCO2 to resting baseline levels
Group II: PoikilocapniaPlacebo Group1 Intervention
Room air-breathing
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Normocapnia
2015
N/A
~20

Find a Location

Who is running the clinical trial?

McMaster UniversityLead Sponsor
884 Previous Clinical Trials
2,598,296 Total Patients Enrolled
Jeremy J Walsh, PhDPrincipal InvestigatorMcMaster University
1 Previous Clinical Trials
20 Total Patients Enrolled

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Which individuals meet the criteria to be eligible for participation in this research investigation?

"To be eligible for this clinical trial, individuals must have cerebral blood flow and fall within the age range of 18 to 35. The study has a total capacity to admit 20 participants in total."

Answered by AI

Are new patients currently being accepted for enrollment in this medical study?

"According to the data available on clinicaltrials.gov, this particular clinical trial is not actively seeking participants at the moment. The study was initially posted on January 9th, 2024 and last updated on January 10th, 2024. However, it's worth noting that there are presently five other ongoing clinical trials that are currently enrolling eligible candidates."

Answered by AI

Is there an age requirement for potential participants in this trial, specifically excluding individuals under the age of 45?

"To be eligible for this clinical trial, individuals must be at least 18 years old and no older than 35 years."

Answered by AI
Recent research and studies
clinicaltrials.govStudy
Mechanistic Effect of Ketones on Cerebral Blood Flow
Jeremy Walsh 2024. "Mechanistic Effect of Ketones on Cerebral Blood Flow". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT06217159.
~0 spots leftby Apr 2024
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