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Selective Serotonin Reuptake Inhibitor
Antidepressant for Depression
N/A
Waitlist Available
Led By Philip Ainslie, PhD
Research Sponsored by University of British Columbia
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial Must have
Be between 18 and 65 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 3 hours following citalopram
Awards & highlights
Study Summary
This trial investigates how a type of antidepressant, which affects serotonin in the brain, influences blood flow to the brain.
Who is the study for?
This trial is for healthy men and women aged 18-35 who haven't used certain drugs in the past year, including SSRIs, MAO inhibitors, or recreational drugs like LSD. They shouldn't have a history of cardiovascular, metabolic, respiratory or neurological diseases; be pregnant; smoke; or have had invasive brain surgery.Check my eligibility
What is being tested?
The study tests how Citalopram (an SSRI antidepressant) affects brain blood flow control compared to a placebo. It's looking at whether this drug can influence the way serotonin helps regulate breathing, blood pressure and cerebral blood flow.See study design
What are the potential side effects?
While not explicitly stated for this trial, common side effects of Citalopram may include nausea, dry mouth, loss of appetite, tiredness, drowsiness and sweating. More serious side effects could occur but are less common.
Timeline
Screening ~ 3 weeks3 visits
Treatment ~ Varies
Follow Up ~ 3 hours following citalopram
Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~3 hours following citalopram
Treatment Details
Study Objectives
Outcome measures can provide a clearer picture of what you can expect from a treatment.Primary outcome measures
Cerebral Blood Flow
Cerebrovascular reactivity to carbon dioxide
Exercise Performance
Secondary outcome measures
Concentration of Platelet serotonin
Trial Design
2Treatment groups
Active Control
Placebo Group
Group I: SSRI visitActive Control1 Intervention
Participants will then undergo pre-intervention testing, with at least 20 minutes of rest between each. Once these tests are complete, the participant will ingest citalopram (40 mg) Then three hours later all tests will be conducted again. Participants will remain in the lab and will be free to read or work during this resting 3 hour period. This will conclude this experimental visit.
Group II: Placebo visitPlacebo Group1 Intervention
Participants will then undergo pre-intervention testing, with at least 20 minutes of rest between each. Once these tests are complete, the participant will ingest a placebo (sugar pill) that is identical in appearance to the drug condition. Three hours after placebo ingestion all tests will be conducted again. Participants will remain in the lab and will be free to read or work during this resting 3 hour period. This will conclude this experimental visit.
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Who is running the clinical trial?
University of British ColumbiaLead Sponsor
1,418 Previous Clinical Trials
2,467,103 Total Patients Enrolled
41 Trials studying Depression
13,323 Patients Enrolled for Depression
Philip Ainslie, PhDPrincipal InvestigatorUniversity of British Columbia
Media Library
Eligibility Criteria:
This trial includes the following eligibility criteria:- I haven't taken serotonin-related drugs in the last 2 weeks.I am not currently taking any medications.I have undergone brain surgery.I have taken monoamine oxidase inhibitors in the last year.I am healthy, aged 18-35, and willing to participate.I am between 18 and 35 years old.I have been on SSRIs or similar drugs in the past year.I have a heart, metabolic, lung, or brain condition.
Research Study Groups:
This trial has the following groups:- Group 1: Placebo visit
- Group 2: SSRI visit
Awards:
This trial has 0 awards, including:Timeline:
This trial has the following timeline:- Screening: It may take up to 3 Weeks to process to see if you qualify in this trial.
- Treatment: The duration you will receive the treatment varies.
- Follow Ups: You may be asked to continue sharing information regarding the trial for 6 Months after you stop receiving the treatment.
Frequently Asked Questions
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
Is enrollment in this experiment still open?
"Eligibility criteria for this trial involves being aged between 18 and 35, as well as diagnosing with depression. The clinical study is looking to recruit a total of 15 participants."
Answered by AI
Is enrollment for this experiment still available to volunteers?
"The listing for this clinical trial on clinicaltrials.gov indicates that recruitment has already closed, with the first post dated August 1st 2023 and the last edit occurring July 19th 2023. However, there are 1210 other studies actively seeking enrolment at present."
Answered by AI
Is the current experiment open to elderly individuals?
"To take part in this study, applicants must be aged between 18 and 35 years old. Concerning younger or older patients, 196 trials are available for those under 18 and 886 other studies cater to individuals over 65."
Answered by AI
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