Caffeine Consumption for Glaucoma
Trial Summary
What is the purpose of this trial?
Caffeine is the most widely consumed drinking nutrient in the world. Caffeine effects various organs and the vascular system. It decreases ocular blood flow due to vasoconstriction.
Will I have to stop taking my current medications?
The trial information does not specify whether you need to stop taking your current medications. It's best to discuss this with the trial coordinators or your doctor.
Is caffeine safe for human consumption?
How does caffeine consumption differ from other treatments for glaucoma?
Caffeine is unique in its potential use for glaucoma as it is not a standard treatment for this condition. Unlike typical glaucoma medications that reduce eye pressure, caffeine's role as an adjuvant (helper) in pain relief is due to its action on adenosine receptors, which is different from the mechanisms of traditional glaucoma drugs.56789
Research Team
M. Reza Razeghinejad, MD
Principal Investigator
Wills Eye Hospital
Eligibility Criteria
This trial is for adults aged 18-90 with primary open-angle glaucoma, as well as healthy individuals without eye diseases. It's not suitable for those with conditions affecting eye test results, severe cataracts, nystagmus, macular degeneration (except mild), diabetic retinopathy, certain optic neuropathies or corneal issues, rheumatologic diseases like Raynaud's phenomenon, pregnant or breastfeeding women, mental illness or alcohol addiction.Inclusion Criteria
Exclusion Criteria
Timeline
Screening
Participants are screened for eligibility to participate in the trial
Baseline Assessment
Participants complete baseline study tasks before caffeine ingestion
Caffeine Ingestion and Monitoring
Participants ingest a 200 mg caffeine tablet and undergo OCTA scans 1 and 2 hours post-ingestion
Follow-up
Participants are monitored for any delayed effects of caffeine on ocular blood flow
Treatment Details
Interventions
- Caffeine
Find a Clinic Near You
Who Is Running the Clinical Trial?
Wills Eye
Lead Sponsor