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Cardiac Rehabilitation for Cardiovascular Disease

N/A

Recruiting

Led By Bruce D Johnson, PhD

Research Sponsored by Mayo Clinic

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Patients with Cardiovascular Disease: Aged 40-years and older. Eligible for cardiac rehabilitation following a cardiac-related hospital admission, coronary artery disease (including angina, myocardial infarction, percutaneous coronary intervention, or coronary artery bypass graft surgery).

Be older than 18 years old

Timeline

Screening 3 weeks

Treatment Varies

Follow Up baseline and follow-up at 3-months

Awards & highlights

Study Summary

This trial will help researchers understand how cardiovascular disease affects brain blood flow and cognition, as well as whether exercise can improve brain blood flow and cognition.

Who is the study for?

This trial is for people aged 40 and older who are eligible for cardiac rehab after a heart-related hospital stay. It's open to those with coronary artery disease but not to individuals previously diagnosed with cardiovascular diseases or risk factors like high blood pressure, high cholesterol, diabetes, obesity (BMI >30), or smoking.Check my eligibility

What is being tested?

The study tests how different intensities of exercise in cardiac rehabilitation affect brain blood flow and cognitive function. Participants will be observed during regular control sessions, high intensity interval training (HIIT), and moderate intensity continuous training (MICT).See study design

What are the potential side effects?

While the trial itself does not list specific side effects, typical risks associated with exercise may include muscle soreness, fatigue, shortness of breath during activity, and in rare cases, heart-related events.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

Select...

I am over 40 and qualify for heart rehab after a heart-related hospital stay.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ baseline and follow-up at 3-months

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~baseline and follow-up at 3-months

This trial's timeline: 3 weeks for screening, Varies for treatment, and baseline and follow-up at 3-months for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

Cerebral blood flow regulation (as cerebrovascular reactivity)

Secondary outcome measures

Cognitive function

Other outcome measures

Cerebral blood flow regulation (as autoregulation)

Cerebral blood flow regulation (as neurovascular coupling)

Cerebral blood flow regulation to exercise

+2 more

Trial Design

5Treatment groups

Experimental Treatment

Active Control

Placebo Group

Group I: Cardiac rehabilitation - observationalExperimental Treatment1 Intervention

This observational group will include patients who are completing an exercise-based cardiac rehabilitation program in line with standard care but are not part of the randomized exercise protocol groups (HIIT or MICT). Participants in this group will be combined with HIIT and MICT (as exercise-based cardiac rehabilitation group) for Aims 1b and 2b.

Group II: Cardiac rehabilitation - High intensity interval training (HIIT)Experimental Treatment1 Intervention

Patients attending cardiac rehabilitation randomized to HIIT.

Group III: Healthy control groupActive Control1 Intervention

Healthy age-matched adults without cardiovascular disease, who will complete baseline assessments only. No intervention period.

Group IV: Cardiac rehabilitation - Moderate intensity continuous training (MICT)Active Control1 Intervention

Patients attending cardiac rehabilitation randomized to MICT.

Group V: Cardiac rehabilitation - controlPlacebo Group1 Intervention

The control group (12 week period) will include participants who have declined cardiac rehabilitation.

0 / 1Eligibility criteria met

Find a Location

Who is running the clinical trial?

Mayo ClinicLead Sponsor

3,207 Previous Clinical Trials

3,766,773 Total Patients Enrolled

Bruce D Johnson, PhDPrincipal InvestigatorMayo Clinic

1 Previous Clinical Trials

80 Total Patients Enrolled

Media Library

Cardiac rehabilitation - control Clinical Trial Eligibility Overview. Trial Name: NCT05012878 — N/A

Cardiovascular Disease Research Study Groups: Healthy control group, Cardiac rehabilitation - Moderate intensity continuous training (MICT), Cardiac rehabilitation - High intensity interval training (HIIT), Cardiac rehabilitation - control, Cardiac rehabilitation - observational

Cardiovascular Disease Clinical Trial 2023: Cardiac rehabilitation - control Highlights & Side Effects. Trial Name: NCT05012878 — N/A

Cardiac rehabilitation - control 2023 Treatment Timeline for Medical Study. Trial Name: NCT05012878 — N/A

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What is the total patient population of this clinical trial?

"Affirmative, per the information on clinicaltrials.gov this clinical trial is actively seeking participants. Initially posted on September 2nd 2021 and last modified on September 13th 2022, 87 people are sought after at a single site for recruitment purposes."

Answered by AI

Is there still availability for participants in this experiment?

"According to the data available on clinicaltrials.gov, this trial is currently recruiting patients and has been open for applications since September 2nd 2021 with updates logged as recently as 13th of September 2022."

Answered by AI

Recent research and studies

clinicaltrials.govStudy

Cardiac Rehab and Cerebral Blood Flow Study

Bruce Johnson 2021. "Cardiac Rehab and Cerebral Blood Flow Study". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT05012878.