Cardiac Rehabilitation for Cardiovascular Disease
Trial Summary
Do I have to stop taking my current medications for this trial?
The trial protocol does not specify whether you need to stop taking your current medications. Please consult with the trial coordinators for more information.
What data supports the idea that Cardiac Rehabilitation for Cardiovascular Disease is an effective treatment?
The available research shows that Cardiac Rehabilitation (CR) is effective in helping people with heart disease. One study highlights that exercise-based CR, including both moderate and high-intensity training, plays a major role in reducing the risk of death and health problems in patients with coronary artery disease. Another study found that high-intensity interval training (HIIT) is becoming popular because it improves fitness levels more than moderate exercise. Additionally, a systematic review suggests that both moderate and high-intensity training methods in CR can improve the health outcomes of heart disease patients. Furthermore, a study on home-based telemonitored CR showed that it can be as effective as traditional outpatient programs, offering flexibility and convenience for patients. Overall, these studies support the effectiveness of CR in improving the health and quality of life for people with heart conditions.12345
What safety data is available for cardiac rehabilitation treatments?
The safety data for cardiac rehabilitation, particularly focusing on high-intensity interval training (HIIT) and moderate-intensity continuous training (MICT), indicates a relatively low rate of major adverse cardiovascular events. A systematic review of 23 studies involving 1117 participants reported one major cardiovascular event per 17,083 training sessions for HIIT. Minor cardiovascular and noncardiovascular events, such as musculoskeletal complaints, were also noted. Overall, HIIT and MICT are considered safe for patients with coronary artery disease or heart failure in cardiac rehabilitation settings.46789
Is cardiac rehabilitation a promising treatment for heart disease?
Yes, cardiac rehabilitation is a promising treatment for heart disease. It helps reduce the risk of death and illness in people with heart problems. Different types of exercises, like high-intensity interval training (HIIT) and moderate-intensity continuous training (MICT), are used to improve heart health. Cardiac rehabilitation can be done in-person or online, making it flexible and accessible for many people.410111213
What is the purpose of this trial?
This study is being done to better understand the influence of cardiovascular disease on brain blood flow regulation and cognitive function, determine whether exercise-based cardiac rehabilitation can lead to better regulation of brain blood flow that may help to improve or maintain cognitive function, and determine whether exercise intensity influences changes in brain blood flow regulation and cognitive function.
Research Team
Bruce D Johnson, PhD
Principal Investigator
Mayo Clinic
Eligibility Criteria
This trial is for people aged 40 and older who are eligible for cardiac rehab after a heart-related hospital stay. It's open to those with coronary artery disease but not to individuals previously diagnosed with cardiovascular diseases or risk factors like high blood pressure, high cholesterol, diabetes, obesity (BMI >30), or smoking.Inclusion Criteria
Timeline
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants undergo either high intensity interval training (HIIT) or moderate intensity continuous training (MICT) as part of cardiac rehabilitation
Follow-up
Participants are monitored for changes in cerebral blood flow regulation and cognitive function
Observational Control
Participants who decline cardiac rehabilitation are monitored as a control group
Treatment Details
Interventions
- Cardiac rehabilitation - control
- Cardiac rehabilitation - high intensity interval training (HIIT)
- Cardiac rehabilitation - moderate intensity continuous training (MICT)
- Cardiac rehabilitation - observational
Cardiac rehabilitation - control is already approved in European Union, United States, Canada, Japan, China, Switzerland for the following indications:
- Cardiovascular disease
- Heart failure
- Coronary artery disease
- Cardiovascular disease
- Heart failure
- Coronary artery disease
- Cardiovascular disease
- Heart failure
- Coronary artery disease
- Cardiovascular disease
- Heart failure
- Coronary artery disease
- Cardiovascular disease
- Heart failure
- Coronary artery disease
- Cardiovascular disease
- Heart failure
- Coronary artery disease
Find a Clinic Near You
Who Is Running the Clinical Trial?
Mayo Clinic
Lead Sponsor