Cardiac rehabilitation - high intensity interval training (HIIT) for Cardiovascular Diseases

Phase-Based Progress Estimates
1
Effectiveness
1
Safety
Mayo Clinic in Rochester, Rochester, MN
Cardiovascular Diseases
Cardiac rehabilitation - high intensity interval training (HIIT) - Behavioral
Eligibility
18+
All Sexes
Eligible conditions
Select

Study Summary

This study is evaluating whether exercise can improve brain blood flow regulation and cognitive function.

See full description

Treatment Effectiveness

Effectiveness Progress

1 of 3

Study Objectives

This trial is evaluating whether Cardiac rehabilitation - high intensity interval training (HIIT) will improve 1 primary outcome, 1 secondary outcome, and 5 other outcomes in patients with Cardiovascular Diseases. Measurement will happen over the course of Baseline and follow-up at 3-months.

Baseline and follow-up at 3-months
Cerebral blood flow regulation (as autoregulation)
Cerebral blood flow regulation (as cerebrovascular reactivity)
Cerebral blood flow regulation (as neurovascular coupling)
Cerebral blood flow regulation to exercise
Cerebral ventricular and white matter hyperintensity volumes
Cognitive function
Resting cerebral blood flow with MRI

Trial Safety

Trial Design

4 Treatment Groups

Cardiac rehabilitation - Moderate intensity continuous training (MICT)
1 of 4
Healthy control group
1 of 4
Cardiac rehabilitation - High intensity interval training (HIIT)
1 of 4
Cardiac rehabilitation - control
1 of 4
Active Control
Experimental Treatment
Non-Treatment Group

This trial requires 87 total participants across 4 different treatment groups

This trial involves 4 different treatments. Cardiac Rehabilitation - High Intensity Interval Training (HIIT) is the primary treatment being studied. Participants will all receive the same treatment. Some patients will receive a placebo treatment. The treatments being tested are not being studied for commercial purposes.

Cardiac rehabilitation - High intensity interval training (HIIT)
Behavioral
Patients attending cardiac rehabilitation randomized to HIIT.
Cardiac rehabilitation - Moderate intensity continuous training (MICT)
Behavioral
Patients attending cardiac rehabilitation randomized to MICT.
Healthy control groupHealthy age-matched adults without cardiovascular disease, who will complete baseline assessments only. No intervention period.
Cardiac rehabilitation - control
Behavioral
The control group (12 week period) will include participants who have declined cardiac rehabilitation.

Trial Logistics

Trial Timeline

Approximate Timeline
Screening: ~3 weeks
Treatment: Varies
Reporting: baseline and follow-up at 3-months
This trial has the following approximate timeline: 3 weeks for initial screening, variable treatment timelines, and roughly baseline and follow-up at 3-months for reporting.

Who is running the study

Principal Investigator
B. J.
Bruce Johnson, Principal Investigator
Mayo Clinic

Closest Location

Mayo Clinic in Rochester - Rochester, MN

Eligibility Criteria

This trial is for patients born any sex aged 18 and older. There are 5 eligibility criteria to participate in this trial as listed below.

Mark “yes” if the following statements are true for you:
Eligible for cardiac rehabilitation following a cardiac-related hospital admission, coronary artery disease (including angina, myocardial infarction, percutaneous coronary intervention, or coronary artery bypass graft surgery).
Aged 40-years and older.
Never been diagnosed with cardiovascular disease or coronary artery disease.
No history of cardiovascular disease risk factors including hypertension, hyperlipidemia, diabetes, obesity (body mass index > 30) or smoking.
Current body mass index < 30kg/m2

Patient Q&A Section

What causes cardiovascular diseases?

"The risk of atherosclerosis and coronary heart disease is more than that of other chronic diseases of the blood vessels. The main cause of cardiovascular disease is a diet with high amounts of saturated and trans fats and low in monounsaturated fats. Dietary fat reduces the level of HDL cholesterol and increases LDL cholesterol. These changes in cholesterol levels can lead to atherosclerosis. The risk of developing cardiovascular disease or death can also be reduced by regular physical activity and the maintenance of a healthy weight." - Anonymous Online Contributor

Unverified Answer

How many people get cardiovascular diseases a year in the United States?

"One hundred and ninety-five million adults aged 20 and older in the United States had a reported [high blood pressure, coronary artery disease, or stroke] in the past year. In addition, one in 6 adults in the United States developed a major CVDs attack in the prior year." - Anonymous Online Contributor

Unverified Answer

Can cardiovascular diseases be cured?

"It seems likely that treatment of high-risk patients can prevent the emergence of cardiovascular diseases in a large proportion of the population. There also exists a possibility of preventing and curing cardiovascular diseases at their onset." - Anonymous Online Contributor

Unverified Answer

What is cardiovascular diseases?

"CVD (Cardiovascular disease) is an illness with a complicated medical and social background, and affects a considerable percentage of the population worldwide. CVD is an umbrella term that includes coronary artery artery diseases and cerebro vascular diseases. Among all ages, men are more frequently affected, and in developing regions, mortality from CVD is higher. Cardiovascular diseases are estimated to cost 16.6% of the total health expenditure in China, and the prevalence of cardiovascular diseases has gradually increased. Given this significant proportion, the prevention and management are particularly important and urgent in the Chinese healthcare system." - Anonymous Online Contributor

Unverified Answer

What are the signs of cardiovascular diseases?

"Cardiovascular diseases can be detected earlier by a change in one's lifestyle including exercise, smoking cessation or consuming healthier foods. These can be beneficial to prevent later development and deterioration of these diseases. Aspirin can also be beneficial for prevention.\n" - Anonymous Online Contributor

Unverified Answer

What are common treatments for cardiovascular diseases?

"This review has highlighted a number of high quality studies conducted to identify and quantify risk factors for the development of CVD. While we are still in the early stages of identifying and understanding why different people develop CVD at different rates, evidence gathered through this review is a valuable resource for practitioners in the management of CVD. This article is protected by copyright. All rights reserved." - Anonymous Online Contributor

Unverified Answer

What does cardiac rehabilitation - high intensity interval training (hiit) usually treat?

"Cardiac rehabilitation using HIIT improves VO2peak. Exercise training and cardiorespiratory fitness are important components of the program to help patients to get healthier and decrease the risk of suffering from heart disease in the future." - Anonymous Online Contributor

Unverified Answer

What are the common side effects of cardiac rehabilitation - high intensity interval training (hiit)?

"With respect to exercise safety, patients should be aware of the common side effects of high-intensity exercise that may occur, such as muscle soreness, overloading, and exhaustion. The most important side effect with a high-intensity exercise is overloading. Therefore, a doctor should be present during exercise and should monitor the patient's weight loss and increase in body temperature to prevent complications." - Anonymous Online Contributor

Unverified Answer

Have there been any new discoveries for treating cardiovascular diseases?

"Some new discoveries have been made in terms of drug discovery, including new drugs for treating cardiovascular diseases, but the development of drugs remains difficult for treating cardiovascular diseases." - Anonymous Online Contributor

Unverified Answer

Does cardiovascular diseases run in families?

"In a recent study, findings suggest that we currently do not have enough information to support the hypothesis that a hereditary predisposition to cardiovascular disease is evident. An underlying genetic basis seems likely though the large difference between the prevalence of a first-degree relative and the rates of multiple affected patients in the general population." - Anonymous Online Contributor

Unverified Answer

Have there been other clinical trials involving cardiac rehabilitation - high intensity interval training (hiit)?

"It is believed that there have been other high intensity interval training studies. However, there are no high quality studies addressing this question. To date there is no evidence from well-designed studies which have been published in peer-reviewed journals that there is any additional benefit of cardiac rehabilitation programmes on cardiac surgery readmission rates. In addition, as the authors have stated their conclusions: "...we found weak or no evidence for a negative effect of cardiac rehabilitation on cardiac surgery readmission rates in this pooled analysis." - Anonymous Online Contributor

Unverified Answer

What is the average age someone gets cardiovascular diseases?

"While there were no significant differences between men and women in overall CV disease prevalence, the findings can be useful for understanding where interventions for both men and women might be effective. It may be that women are at higher risk of developing cardiovascular disease than men at a younger age (e.g., in adolescence), because men had better CV recovery. However, men and women displayed similar CVD recovery as they advanced in age, suggesting that men and women at a similar age have similar CVD recovery." - Anonymous Online Contributor

Unverified Answer
Please Note: These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
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