Casein Protein for Metabolism

Age: 18 - 65

Sex: Male

Trial Phase: Phase < 1

Sponsor: Ohio University

Disqualifiers: Lactose intolerant, Sleep issues, Non-uniform schedule, Animal-free diet, Food allergies, Health conditions, others

Compensation: Varies

Number of Visits: 2

Duration: 1 day

15 Participants Needed

Trial Summary

What is the purpose of this trial?

The purpose of this study is to investigate the effect of casein protein consumption both prior to sleep as well first thing in the morning on metabolism (increase satiety and appetite, lower resting metabolic rate, and lower blood sugar levels), when compared to nighttime protein or placebo consumption alone. Protein itself is a macronutrient that not only helps the body repair itself, and play a critical role in growth, it also aids in increasing satiety and decreasing appetite. Casein protein specifically is slow digesting dairy protein which may impact the body's metabolism for a longer period than other dairy proteins such as whey. The literature demonstrates nighttime protein ingestion prior to sleep increases metabolic rate and satiety the next morning. However, there appears to be no data on the metabolic effects of protein ingested both at night and in the morning.

Eligibility Criteria

This trial is for individuals interested in understanding how casein protein affects their metabolism. Participants should be willing to consume casein protein before sleep and in the morning, or a placebo, to compare effects on satiety, metabolic rate, and blood sugar levels.

Inclusion Criteria

I am male.

Exclusion Criteria

Those who do not eat animal-based diets

Any known or suspected food allergies

I have a known health condition like heart disease, IBS, high blood pressure, diabetes, or Crohn's disease.

Timeline

Screening

Participants are screened for eligibility to participate in the trial

1-2 weeks

Treatment

Participants consume casein protein or placebo shakes prior to sleep and in the morning, with metabolic assessments conducted

1 day

2 visits (in-person)

Follow-up

Participants are monitored for safety and effectiveness after treatment

1-2 weeks

Treatment Details

Interventions

• Casein Protein

Trial Overview The study tests the impact of consuming casein protein at two different times: before sleeping and upon waking up. It aims to see if this regimen can increase fullness, lower hunger, boost resting metabolism, and reduce blood sugar compared to taking nighttime protein or a placebo alone.

Participant Groups

Group I: PRO pm, PRO am Experimental Treatment 1 Intervention

Participants arrive to the lab, complete 30 mins resting metabolic rate assessment. Then they are provided with a shake to drink 30 mins before bed. They return to the lab the following morning for 30 min RMR, drink another shake and do 30 mins RMR before leaving the lab.

Group II: PRO pm, PLAC am Experimental Treatment 1 Intervention

Participants arrive to the lab, complete 30 mins resting metabolic rate assessment. Then they are provided with a shake to drink 30 mins before bed. They return to the lab the following morning for 30 min RMR, drink another shake and do 30 mins RMR before leaving the lab.

Group III: PLAC pm, PRO am Experimental Treatment 1 Intervention

Participants arrive to the lab, complete 30 mins resting metabolic rate assessment. Then they are provided with a shake to drink 30 mins before bed. They return to the lab the following morning for 30 min RMR, drink another shake and do 30 mins RMR before leaving the lab.

Group IV: PLAC pm, PLAC pm Placebo Group 1 Intervention

Participants arrive to the lab, complete 30 mins resting metabolic rate assessment. Then they are provided with a shake to drink 30 mins before bed. They return to the lab the following morning for 30 min RMR, drink another shake and do 30 mins RMR before leaving the lab.

Who Is Running the Clinical Trial?

Ohio University

Lead Sponsor

Trials

73

Recruited

17,800+