Intervention for Brain Aging

Phase-Based Progress Estimates
1
Effectiveness
1
Safety
University of Kansas Medical Center, Kansas City, KS
Brain Aging
Intervention - DietarySupplement
Eligibility
65+
All Sexes
Eligible conditions
Select

Study Summary

Blueberry Intervention Study for Brain Aging

See full description

Treatment Effectiveness

Effectiveness Progress

1 of 3

Study Objectives

This trial is evaluating whether Intervention will improve 2 primary outcomes in patients with Brain Aging. Measurement will happen over the course of Change from baseline to 3 months.

Month 3
Change in brain glutathione (GSH) levels
Change in cerebral blood flow (CBF)

Trial Safety

Safety Progress

1 of 3

Trial Design

2 Treatment Groups

Control
1 of 2
Intervention
1 of 2
Active Control
Experimental Treatment

This trial requires 65 total participants across 2 different treatment groups

This trial involves 2 different treatments. Intervention is the primary treatment being studied. Participants will all receive the same treatment. There is no placebo group. The treatments being tested are not being studied for commercial purposes.

Intervention
DietarySupplement
Participants will receive the dietary intervention. Participants will take 1 serving of blueberries/day.
Control
DietarySupplement
Participants will receive a placebo. Participants will take 1 serving of placebo/day.
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Intervention
2011
Completed Phase 4
~73850

Trial Logistics

Trial Timeline

Approximate Timeline
Screening: ~3 weeks
Treatment: Varies
Reporting: change from baseline to 3 months
This trial has the following approximate timeline: 3 weeks for initial screening, variable treatment timelines, and roughly change from baseline to 3 months for reporting.

Who is running the study

Principal Investigator
I. C. P.
Prof. In-Young Choi Ph.D., Professor of Neurology
University of Kansas Medical Center

Closest Location

University of Kansas Medical Center - Kansas City, KS

Eligibility Criteria

This trial is for patients born any sex aged 65 and older. There are 5 eligibility criteria to participate in this trial as listed below.

Mark “yes” if the following statements are true for you:
Speak English as the primary language and be able to read and write.
Good general health with no concomitant diseases
Low berry consumption (≤1 serving/week)
Cognitively normal (Mini-Mental State Exam Score ≥24)
BMI range=18.5-35 kg/m2.

Patient Q&A Section

What causes brain aging?

"The normal process of brain aging in our brain is a response to accumulated degenerative changes over time as well as a recovery to maintain an age-matched function to the brain. This is caused by many physical and mental factors on an individual as well as environmental factors. Our brain aging can be affected by many factors such as smoking, poor diet and chronic health conditions. Understanding the factors that contribute to our brain aging allows for better prevention of brain aging. One method for preservation of brain functioning and health is to create and have healthy life choices for those exposed to the risk factors for our brain aging." - Anonymous Online Contributor

Unverified Answer

Can brain aging be cured?

"As we age, the brain accumulates harmful compounds and proteins. Understanding how to remove these aggregates has been an active field of research due to its promise of halting brain aging. This article addresses one of the most clinically appealing strategies to treat the brain aging process: using the [amyloid beta protein] protein to remove brain aggregates. The [amyloid beta protein] protein is part of the [amyloid plaques and peptide tangles] aggregation cascade, and removing it eliminates the formation of these tangles." - Anonymous Online Contributor

Unverified Answer

How many people get brain aging a year in the United States?

"The frequency of brain aging is high enough that it would be considered a public health concern if it were not also known to be associated with significant mortality. Data from a recent study suggest that further efforts to address brain aging risk will be needed." - Anonymous Online Contributor

Unverified Answer

What are the signs of brain aging?

"Most of the signs of brain aging occur during an individual's middle years (40-60 years old). While aging can cause various symptoms (such as memory trouble, poor concentration, and loss of brain function), these signs of brain aging can't be explained just by age." - Anonymous Online Contributor

Unverified Answer

What are common treatments for brain aging?

"Treatment depends on age, but is typically supportive and focuses on patient functioning. Cognitive and psychiatric impairments are the primary concerns, if present at all, and may benefit from medications such as antidepressants, benzodiazepine or anticonvulsants." - Anonymous Online Contributor

Unverified Answer

What is brain aging?

"When compared with a younger group of patients, people who suffer from dementia are more likely to have higher levels of homocysteine in their cerebrospinal fluid, which is thought to decrease the viability of brain cells. Additionally, studies have suggested that dementia increases the risk for future cardiovascular disease. This may be because people who suffer from dementia have higher levels of homocysteine in their blood. Therefore, it is essential to reduce the homocysteine levels in the older age groups. In order to reduce the homocysteine in their diets, many doctors recommend supplements such as folic acid to add to any vitamins, supplements, and amino acids already in their diets." - Anonymous Online Contributor

Unverified Answer

How serious can brain aging be?

"Results from a recent clinical trial provides an overview of this recent progress of basic scientific research on brain aging and a conceptual framework for translating that knowledge to improved cognitive rehabilitation of age-associated Alzheimer's disease and the elderly living with brain dysfunction. In the light of recent dramatic progress made in the field of functional brain brain imaging, it is reasonable to conclude that the brain is not a passive organ but a highly adaptable system that responds to environmental changes both by plastic and maladaptive changes." - Anonymous Online Contributor

Unverified Answer

What is the average age someone gets brain aging?

"Brain aging is a gradual process in the brain. It usually starts in the early teens for men and women, and in late adolescence in girls, and continues into old age. The average age in which the brain aging process starts is similar in males and females around the age of 11-12. The average age in which the brain aging process starts is close to the adult age of men and women at around 70." - Anonymous Online Contributor

Unverified Answer

Have there been any new discoveries for treating brain aging?

"There are still many things that we need to look into before we can understand brain aging. There's still a lot of space for new treatments for brain aging." - Anonymous Online Contributor

Unverified Answer

Is intervention safe for people?

"There are few randomized controlled trials of people with brain aging, but we found evidence of safe and positive effects. More studies of both positive and negative effects are needed." - Anonymous Online Contributor

Unverified Answer

Have there been other clinical trials involving intervention?

"Despite the number of randomized pilot design studies for neuroprotection against ischemic injury, there have not been any clinical studies for intervention against neuroprotection due to a lack of standardized clinical trials with the appropriate design standards. We propose a guideline to define an intervention to be tested in a clinical trial and a minimum requirement for design standards to be met for clinical trials." - Anonymous Online Contributor

Unverified Answer

Is intervention typically used in combination with any other treatments?

"The use of medication alone is the most frequently used combination treatment in early Alzheimer's disease. Intervention in isolation is the least commonly used combination of treatment. Findings from a recent study provide basic information about the use of treatment and care of early AD by different providers." - Anonymous Online Contributor

Unverified Answer
Please Note: These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
See if you qualify for this trial
Get access to this novel treatment for Brain Aging by sharing your contact details with the study coordinator.