Your session is about to expire
← Back to Search
Cerebral Vascular Function Test for Stroke Risk Assessment
N/A
Recruiting
Led By Alexander J Rosenberg, PhD
Research Sponsored by University of Illinois at Chicago
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial Must have
Postmenopausal women (at least 12 months since last menstrual cycle) who are not on hormone replacement therapy will be eligible
Aged between 18-35 years (Young) or 60-80 years (Older)
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 3-months
Awards & highlights
Study Summary
This trial is testing a way to measure the function of blood vessels in the brain. The results could help predict an individual's risk of having a stroke or other cerebrovascular event.
Who is the study for?
This trial is for healthy young adults aged 18-35 or older adults 60-80, non-smokers, with normal heart activity and blood pressure. Women must not be pregnant and if of childbearing potential, agree to testing. Participants should be sedentary or moderately active without a history of cardiovascular or respiratory illness, abnormal clotting, or mental health issues that could affect study completion.Check my eligibility
What is being tested?
The study aims to develop a test for brain vessel function by responding to increased carbon dioxide levels. It involves measuring the reactivity of cerebral vessels and flow dilation in arm and leg arteries. The goal is to predict individual risk for future stroke or cerebrovascular disease.See study design
What are the potential side effects?
There may be minimal side effects since this trial focuses on diagnostic testing rather than medication or invasive procedures. However, participants might experience discomfort from wearing tight equipment during tests or dizziness due to changes in breathing patterns.
Eligibility Criteria
Inclusion Criteria
You may be eligible if you check “Yes” for the criteria belowSelect...
I am a postmenopausal woman not on hormone therapy.
Select...
I am either between 18-35 years old or 60-80 years old.
Select...
I am on oral contraceptives and can be tested during my low hormone or placebo phase.
Select...
I am a premenopausal woman and will be tested soon after my period starts.
Select...
I have a negative pregnancy test result.
Select...
I am willing and able to agree to participate in the study.
Select...
I have smoked at least 20 pack-years.
Timeline
Screening ~ 3 weeks3 visits
Treatment ~ Varies
Follow Up ~ 3-months
Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~3-months
Treatment Details
Study Objectives
Outcome measures can provide a clearer picture of what you can expect from a treatment.Primary outcome measures
Cerebral vascular function
Cerebral vascular reactivity to carbon dioxide (CO2)
Flow mediated dilation (brachial and femoral arteries)
Trial Design
1Treatment groups
Experimental Treatment
Group I: Arm 1Experimental Treatment3 Interventions
Find a Location
Who is running the clinical trial?
University of Illinois at ChicagoLead Sponsor
607 Previous Clinical Trials
1,559,262 Total Patients Enrolled
19 Trials studying Stroke
2,251 Patients Enrolled for Stroke
National Heart, Lung, and Blood Institute (NHLBI)NIH
3,835 Previous Clinical Trials
47,310,549 Total Patients Enrolled
86 Trials studying Stroke
537,505 Patients Enrolled for Stroke
Alexander J Rosenberg, PhDPrincipal InvestigatorUniversity of Illinois at Chicago
Media Library
Eligibility Criteria:
This trial includes the following eligibility criteria:- I frequently use medication to help me breathe.Your regular heart test (checked by a doctor) is normal.I have not donated blood in the last 60 days.I have or had a thyroid condition, including hyperthyroidism.You have had a concussion or lost consciousness in the last 30 days.My blood pressure is high or I have an abnormal heart rhythm.I have or might have an abdominal hernia.I have smoked less than 20 pack-years and haven't used tobacco/nicotine products in the last 6 months.I use long-term hormonal birth control and do not have regular periods.I have a chronic respiratory condition like asthma or COPD.I am a postmenopausal woman not on hormone therapy.I am either between 18-35 years old or 60-80 years old.I am on oral contraceptives and can be tested during my low hormone or placebo phase.I have plaque buildup in my carotid arteries.I have a metabolic disease but am only on cholesterol-lowering medications.I am currently on blood thinner medication.I am under 18, between 40-60, or over 80 years old.I have a history of fainting or feeling faint when standing up.I am a premenopausal woman and will be tested soon after my period starts.I am not currently using any medication that affects my nervous system, or it has been cleared for the study.I or my family have a history of blood clots in the legs, pelvis, or lungs.You are pregnant.You have depression, anxiety, or other mental health issues that make it hard for you to take part in this study.Your blood pressure is lower than 140/90 mmHg when measured in a lab.I have been diagnosed with peripheral artery disease.I have a negative pregnancy test result.I am willing and able to agree to participate in the study.My menstrual cycle is irregular.You haven't gone without eating for at least 3-4 hours before the study sessions.I am currently taking beta blockers.Your body mass index (BMI) is less than 40, unless you have a very muscular build. This is to make sure you can fit inside the LBNP chamber.I am older and take two or more blood pressure medications.I have a history of stroke, mini-strokes, or seizures.You have had a severe allergic reaction called anaphylaxis in the past.Your body mass index (BMI) is over 40, unless you are very muscular or athletic.I am on hormone replacement therapy.You have used tobacco or nicotine products regularly in the past 6 months.I have a condition affecting my body's automatic functions, like blood pressure or heart rate.I have smoked at least 20 pack-years.You don't use any tobacco or nicotine products like cigarettes, chewing tobacco, or nicotine gum.You don't regularly exercise or engage in physical activities for fun.
Research Study Groups:
This trial has the following groups:- Group 1: Arm 1
Awards:
This trial has 1 awards, including:- No Placebo-Only Group - All patients enrolled in this study will receive some form of active treatment.
Timeline:
This trial has the following timeline:- Screening: It may take up to 3 Weeks to process to see if you qualify in this trial.
- Treatment: The duration you will receive the treatment varies.
- Follow Ups: You may be asked to continue sharing information regarding the trial for 6 Months after you stop receiving the treatment.
Frequently Asked Questions
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
Who might be eligible to participate in this research initiative?
"This clinical investigation is open to 93 people with cerebrovascular disorders who are aged 18 to 80. Eligibility also requires postmenopausal women (who have gone 12 months without a menstrual cycle) not on hormone therapy, being sedentary or having low-level physical activity, and no tobacco/nicotine usage in the last year. Additionally, applicants must be either Young adults between 18 and 35 years old or Seniors of 60-80 years old will qualify too."
Answered by AI
Does this research endeavor accommodate participants older than 65 years of age?
"This clinical trial is recruiting adult patients aged 18-80."
Answered by AI
Are individuals still being accepted to this clinical experiment?
"Clinicaltrials.gov states that the search for suitable participants is ongoing; with the initial posting of this trial on September 14th, 2018 and its most recent update occurring on May 17th, 2022."
Answered by AI
What is the upper-limit of volunteers for this research project?
"Affirmative, the clinicaltrials.gov database denotes that this research program is actively searching for participants. Inception of the study was on September 14th 2018, with a most recent update dated May 17th 2022; and it seeks to recruit 93 individuals from two different enclaves."
Answered by AI
Who else is applying?
What state do they live in?
Texas
How old are they?
65+
What site did they apply to?
University of North Texas Health Science Center
What portion of applicants met pre-screening criteria?
Met criteria
Recent research and studies
Other Trials to Consider
Popular Categories
Share this study with friends
Copy Link
Messenger