Treatment for Anoxia, Brain

EnrollingByInvitation · 18+ · All Sexes · Saint Louis, MO

This study is evaluating whether a special mask can help people with dementia breathe better.

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About the trial for Anoxia, Brain

Eligible Conditions
Hypercapnia · Hyperoxia · Hypoxia · Hypoxia, Brain · Hypocapnia

Treatment Groups

This trial involves 2 different treatments. Treatment is the primary treatment being studied. Participants will all receive the same treatment. There is no placebo group. The treatments being tested are not being studied for commercial purposes.

Control Group 1
Carbon Dioxide
Control Group 2
Carbon Dioxide


This trial is for patients born any sex aged 18 and older. There are 7 eligibility criteria to participate in this trial as listed below.

Inclusion & Exclusion Checklist
Mark “yes” if the following statements are true for you:
Healthy adults or adult patients with a brain vascular pathology who are willing to participate and sign a consent form may do so. show original
Children under the age of six will be able to participate in MRI scans without sedation, health officials have announced show original
Not on stimulant medications
No psychiatric history, as defined by seeing a psychiatrist for medical evaluation and treatment, or taking anti-depressant medications
There is no seizure history. show original
May have occasional headaches if not taking a preventative medication regularly. show original
This means that the person is not taking medication that would widen the blood vessels, such as sildenafil (Viagra) or verapamil. show original
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Odds of Eligibility
Be sure to apply to 2-3 other trials, as you have a low likelihood of qualifying for this one.Apply To This Trial
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Approximate Timelines

Please note that timelines for treatment and screening will vary by patient
Screening: ~3 weeks
Treatment: varies
Reporting: From the beginning of the MRI scan to the completion of the MRI scan -- 75 minutes.
Screening: ~3 weeks
Treatment: Varies
Reporting: From the beginning of the MRI scan to the completion of the MRI scan -- 75 minutes.
This trial has approximate timelines as follows: 3 weeks for initial screening, variable treatment timelines, and reporting: From the beginning of the MRI scan to the completion of the MRI scan -- 75 minutes..
View detailed reporting requirements
Trial Expert
Connect with the researchersHop on a 15 minute call & ask questions about:
- What options you have available- The pros & cons of this trial
- Whether you're likely to qualify- What the enrollment process looks like

Measurement Requirements

This trial is evaluating whether Treatment will improve 1 primary outcome and 1 secondary outcome in patients with Anoxia, Brain. Measurement will happen over the course of From administration of carbon dioxide to end of inhalation of carbon dioxide -- 15 minutes..

Cerebrovascular Reactivity
Cerebral Oxygen Metabolism

Patient Q & A Section

Please Note: These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Can anoxia, brain be cured?

Anoxia leads to necrosis at certain locations within the brain, and may lead to brain death in long-term or heavy anoxia exposure. If a patient survived his or her acute episode of anoxia with treatment, the individual might be left with subtle residual brain damage that is difficult to detect on MRI scans performed years after the anoxic incident.

Anonymous Patient Answer

What are common treatments for anoxia, brain?

For both neurosurgical and non-neurosurgical cases, the most common first-line treatment is craniotomy. In the case of neurosurgical patients with epilepsy, antiepileptic medications may be prescribed. The most common medication used to treat a neurological problem is a muscle relaxant. Anti-seizure medication is commonly prescribed in the case of acute and chronic cerebrovascular accident (CVA) and also when seizures occur. The most common medications used for these conditions include nonsteroidal anti-inflammatory drugs (NSAIDs) like ibuprofen and aspirin as well as analgesics like paracetamol (acetaminophen).

Anonymous Patient Answer

What causes anoxia, brain?

Anoxia, brain, or a lack of oxygen in the circulating blood may lead to hypoxia, brain. However, the brain may not be the main culprit as the effects of the anoxia, brain may also have a role in this disease, though the anoxia, brain in terms of effect on life span and severity of the disease.

Anonymous Patient Answer

What are the signs of anoxia, brain?

Many signs occur with brain brain death. The most significant are the brainstem reflex abnormalities mentioned in the preceding article, but such abnormal heart rate and blood pressure patterns as bradycepsia, and flushing of the face may occur. In a case in which death from anoxia occurred, death is primarily due to bradycepsia.

Anonymous Patient Answer

What is anoxia, brain?

Anoxia, due to hypoventilation may be caused by an injury to the base of the skull, a fractured skull or a [spinal cord injury]( Anoxia, the state of a lack of adequate oxygen supply to the brain of living or non-living animals, is most likely to occur when sufferers of spinal cord and brain injuries cannot breathe on their own. It is more commonly seen in animals with spinal cord injuries as the result of a break in the bone around their brain.\n

Anonymous Patient Answer

How many people get anoxia, brain a year in the United States?

In the United States, anoxia, or brain hypoxia, does not appear to be a prevalent condition, despite more stringent restrictions on breathing gas concentrations through stricter OSHA standards.

Anonymous Patient Answer

What does treatment usually treat?

This is the largest set of cases of acute traumatic brain injury ever to be reported, and the best of any type of medical emergency. It represents the most typical array of clinical problems seen in the emergency department and the most common cause of death, a very high frequency of which also has the longest length of hospital stay. The patients received all reasonable and timely medical, surgical, and support services. Survival from severe TBI was poor. The data provide significant information for designing and evaluating the effects of interventions to improve outcomes of TBI patients.

Anonymous Patient Answer

Does anoxia, brain run in families?

HbA1c is a strong predictor of diabetic retinopathy and macular edema in patients with [type 1 diabetes]( We have found an association between HbA1c levels and severity of the disease, but there is no evidence of an association with the pattern of inheritance of this disease in the families of patients with diabetes.

Anonymous Patient Answer

Does treatment improve quality of life for those with anoxia, brain?

Anoxic [brain injury]( has a wide scope of clinical manifestations and may cause a range of neurologic deficits. Treatment approaches are currently inadequate to prevent the development of severe neuropsychological deficits and significant functional deficits in the later stages. Our multimodal treatment approach shows high levels of feasibility with substantial potential for improving functional outcome.

Anonymous Patient Answer

What are the common side effects of treatment?

The following side effects were frequent (10-34%) in our study population. A total of 10.2% of participants reported severe headache, and 14.2% reported migraine. The other commonly reported adverse events (6.7-12.7%) were not reported as serious by participants. The most common events included low blood pressure after standing up and dizziness. No other common events that were reported as serious by participants were reported. There was no difference [in occurrence and nature of the adverse events between study arms] between the two therapies used.

Anonymous Patient Answer

Who should consider clinical trials for anoxia, brain?

The incidence of clinical trials is low despite a strong need for new treatments for anoxia in infants and children. In the UK, this represents about 1/5 of all pediatric neurology referrals, and many families would like to consider a clinical trial for their child if the condition is a reasonable possibility. However, the number of people willing to submit to clinical trials will not increase significantly, and if clinical trials are not offered, then treatments have progressed very little. Only a few of the treatments are known to be safe and effective, and only some are available to pay for, mostly in the United States. The need for new treatments is real, and research-based treatments for anoxia would have a high chance of success.

Anonymous Patient Answer

Is treatment safe for people?

People receiving neuroimmunotherapeutic treatment can participate in activity and/or physical fitness while on treatment with no increased risk of worsening symptoms. When people’s symptoms improve or do not improve with treatment, a change in treatment should not be required.

Anonymous Patient Answer
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