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Carbon Dioxide Challenge for Brain Blood Flow
N/A
Waitlist Available
Research Sponsored by Washington University School of Medicine
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial Must have
No psychiatric history, as defined by seeing a psychiatrist for medical evaluation and treatment, or taking anti-depressant medications
Not on vasodilatory medication, such as sildenafil or verapamil
Timeline
Screening 3 weeks
Treatment Varies
Follow Up from the beginning of the mri scan to the completion of the mri scan -- 75 minutes.
Awards & highlights
Study Summary
This trial will study how well the brain's blood vessels respond to breathing in carbon dioxide in patients with and without diseases that are known to cause problems with blood flow.
Who is the study for?
This trial is for healthy adults over 18 or those with brain vascular issues, without a history of seizures, psychiatric conditions, or on certain medications like vasodilators. Participants must be able to undergo an MRI without sedation and not require daily headache prevention meds.Check my eligibility
What is being tested?
The study tests how the brain's blood vessels respond to different levels of carbon dioxide and oxygen using a special mask during MRI imaging. It aims to understand blood flow and metabolism changes in normal individuals versus patients with disease.See study design
What are the potential side effects?
While not explicitly listed, potential side effects may include discomfort from wearing the mask, dizziness or lightheadedness due to changes in breathing gases, and typical MRI-related concerns such as claustrophobia.
Eligibility Criteria
Inclusion Criteria
You may be eligible if you check “Yes” for the criteria belowSelect...
I have not seen a psychiatrist nor taken antidepressants.
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I am not taking any medication that widens my blood vessels.
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I have never had a seizure.
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I can undergo an MRI scan without needing to be sedated.
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I am not taking any stimulant medications.
Timeline
Screening ~ 3 weeks3 visits
Treatment ~ Varies
Follow Up ~ from the beginning of the mri scan to the completion of the mri scan -- 75 minutes.
Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~from the beginning of the mri scan to the completion of the mri scan -- 75 minutes.
Treatment Details
Study Objectives
Outcome measures can provide a clearer picture of what you can expect from a treatment.Primary outcome measures
Cerebral Oxygen Metabolism
Secondary outcome measures
Cerebrovascular Reactivity
Trial Design
2Treatment groups
Active Control
Group I: Healthy AdultsActive Control1 Intervention
Group II: Adults diagnosed with vascular pathology of the brainActive Control1 Intervention
Find a Location
Who is running the clinical trial?
Washington University School of MedicineLead Sponsor
1,933 Previous Clinical Trials
2,299,677 Total Patients Enrolled
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Eligibility Criteria:
This trial includes the following eligibility criteria:- I sometimes have headaches but don't take daily medication for them.I am unable to undergo rehabilitation therapy.I have not seen a psychiatrist nor taken antidepressants.I am not taking any medication that widens my blood vessels.I cannot have an MRI due to a health condition, device, or metal in my body.I have never had a seizure.I have severe heart failure or lung disease with a resting breathing rate over 15 breaths per minute.I need portable oxygen for breathing, either at rest or during physical activity.My lung condition causes high CO2 or bicarbonate levels in my blood.I refuse to undergo any testing.I cannot climb stairs without feeling short of breath due to heart or lung disease.I have a pre-existing condition that affects my breathing or blood acidity.I am over 18 and willing to sign a consent form.I can undergo an MRI scan without needing to be sedated.I am not taking any stimulant medications.
Research Study Groups:
This trial has the following groups:- Group 1: Healthy Adults
- Group 2: Adults diagnosed with vascular pathology of the brain
Awards:
This trial has 1 awards, including:- No Placebo-Only Group - All patients enrolled in this study will receive some form of active treatment.
Timeline:
This trial has the following timeline:- Screening: It may take up to 3 Weeks to process to see if you qualify in this trial.
- Treatment: The duration you will receive the treatment varies.
- Follow Ups: You may be asked to continue sharing information regarding the trial for 6 Months after you stop receiving the treatment.
Frequently Asked Questions
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
Are there still spots open for people who want to participate in this clinical trial?
"No, this trial is not currently looking for patients. The most recent update on clinicaltrials.gov was on October 7th, 2021 and the study was first posted on January 29th, 2020. That being said, there are 214 other studies that are actively recruiting right now."
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