MDMA for Borderline Personality Disorder
(MDMA in BPD Trial)
What You Need to Know Before You Apply
What is the purpose of this trial?
The purpose of this study is to test the effects of MDMA (3,4-methylenedioxymethamphetamine) on social cognition in adults with Borderline Personality Disorder.
Will I have to stop taking my current medications?
Yes, you will need to stop taking any prescribed medications, except for hormonal contraceptives, before participating in the trial.
Is MDMA generally safe for humans?
MDMA has been used in clinical trials for PTSD, showing some promise, but it can also cause serious side effects like brain damage, psychiatric issues, and severe physical reactions such as high fever and heart problems. Even in its pure form, MDMA can lead to dangerous complications like brain bleeding, so it should not be considered a safe drug.12345
How is the drug MDMA unique in treating Borderline Personality Disorder?
MDMA is unique because it acts on serotonin receptors and has been used in therapy for PTSD, showing potential for treating psychiatric disorders that are resistant to other treatments. Its ability to enhance mood and social interactions may offer a novel approach for conditions like Borderline Personality Disorder.16789
What evidence supports the effectiveness of the drug MDMA for treating borderline personality disorder?
Research suggests that MDMA-assisted psychotherapy has shown promise in treating conditions similar to borderline personality disorder, like PTSD, by enhancing the effectiveness of therapy. This is based on studies where MDMA helped improve symptoms in PTSD patients, indicating potential benefits for borderline personality disorder as well.1011121314
Who Is on the Research Team?
Sarah K Fineberg, MD, PhD
Principal Investigator
Yale University
Are You a Good Fit for This Trial?
This trial is for adults with Borderline Personality Disorder. Specific eligibility criteria are not provided, but typically participants must meet diagnostic criteria for the condition being studied and may need to pass certain health checks.Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants receive one dose of open-label MDMA
Follow-up
Participants are monitored for changes in social cognition and emotion appraisal
What Are the Treatments Tested in This Trial?
Interventions
- MDMA
MDMA is already approved in United States for the following indications:
Find a Clinic Near You
Who Is Running the Clinical Trial?
Yale University
Lead Sponsor
Connecticut Mental Health Center
Collaborator